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Burfeind KG, Murchison CF, Westaway SK, et al. The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease. Alzheimers Dement (N Y). 2017;3(3):348-359doi: 10.1016/j.trci.2017.05.001.
Burfeind, K. G., Murchison, C. F., Westaway, S. K., Simon, M. J., Erten-Lyons, D., Kaye, J. A., Quinn, J. F., & Iliff, J. J. (2017). The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease. Alzheimer's & dementia (New York, N. Y.), 3(3), 348-359. https://doi.org/10.1016/j.trci.2017.05.001
Burfeind, Kevin G, et al. "The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease." Alzheimer's & dementia (New York, N. Y.) vol. 3,3 (2017): 348-359. doi: https://doi.org/10.1016/j.trci.2017.05.001
Burfeind KG, Murchison CF, Westaway SK, Simon MJ, Erten-Lyons D, Kaye JA, Quinn JF, Iliff JJ. The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease. Alzheimers Dement (N Y). 2017 May 26;3(3):348-359. doi: 10.1016/j.trci.2017.05.001. eCollection 2017 Sep. PMID: 29067342; PMCID: PMC5651426.
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Alzheimers Dement (N Y). 2017 May 26;3(3):348-359. doi: 10.1016/j.trci.2017.05.001. eCollection 2017 Sep.

The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease.

Alzheimer's & dementia (New York, N. Y.)

Kevin G Burfeind, Charles F Murchison, Shawn K Westaway, Matthew J Simon, Deniz Erten-Lyons, Jeffrey A Kaye, Joseph F Quinn, Jeffrey J Iliff

Affiliations

  1. Department of Anesthesiology and Perioperative Medicine, Oregon Health & Science University, Portland, OR, USA.
  2. Department of Neurology, Oregon Health & Science University, Portland, OR, USA.
  3. Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, USA.

PMID: 29067342 PMCID: PMC5651426 DOI: 10.1016/j.trci.2017.05.001

Abstract

INTRODUCTION: The glymphatic system is a brain-wide perivascular network that facilitates clearance of proteins, including amyloid β, from the brain interstitium through the perivascular exchange of cerebrospinal fluid and interstitial fluid. The astrocytic water channel aquaporin-4 (AQP4) is required for glymphatic system function, and impairment of glymphatic function in the aging brain is associated with altered AQP4 expression and localization. In human cortical tissue, alterations in AQP4 expression and localization are associated with Alzheimer's disease (AD) status and pathology. Although this suggests a potential role for AQP4 in the development or progression of AD, the relationship between of naturally occurring variants in the human

METHODS: Using data from several longitudinal aging cohorts, we investigated the association between five

RESULTS: None of the five SNPs were associated with different rates of AD diagnosis, age of dementia onset in trial subjects. No association between

DISCUSSION: These results provide the first evidence that variations in the

Keywords: Alzheimer's disease; Amyloid β; Aquaporin-4; Cognitive decline; Cohort study; Genetics; Glymphatic system

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