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Quinn JF, Harris C, Kaye JA, et al. Gender effects on plasma and brain copper. Int J Alzheimers Dis. 2011;2011:150916doi: 10.4061/2011/150916.
Quinn, J. F., Harris, C., Kaye, J. A., Lind, B., Carter, R., Anekonda, T., & Ralle, M. (2011). Gender effects on plasma and brain copper. International journal of Alzheimer's disease, 2011150916. https://doi.org/10.4061/2011/150916
Quinn, Joseph F, et al. "Gender effects on plasma and brain copper." International journal of Alzheimer's disease vol. 2011 (2011): 150916. doi: https://doi.org/10.4061/2011/150916
Quinn JF, Harris C, Kaye JA, Lind B, Carter R, Anekonda T, Ralle M. Gender effects on plasma and brain copper. Int J Alzheimers Dis. 2011;2011:150916. doi: 10.4061/2011/150916. Epub 2011 Oct 19. PMID: 22028982; PMCID: PMC3199105.
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Int J Alzheimers Dis. 2011;2011:150916. doi: 10.4061/2011/150916. Epub 2011 Oct 19.

Gender effects on plasma and brain copper.

International journal of Alzheimer's disease

Joseph F Quinn, Christopher Harris, Jeffrey A Kaye, Babett Lind, Raina Carter, Thimmappa Anekonda, Martina Ralle

Affiliations

  1. Department of Neurology, Portland VA Medical Center and Oregon Health & Science University, Portland, OR 97239, USA.

PMID: 22028982 PMCID: PMC3199105 DOI: 10.4061/2011/150916

Abstract

The effect of gender on systemic and brain levels of copper is relatively understudied. We examined gender effects in mice and human subjects. We observed a trend to higher serum copper levels in female compared to male LaFerla "triple transgenic" (1399 ± 233 versus 804 ± 436 ng/mL, P = 0.06) mice, and significantly higher brain copper levels in female- versus male wild-type mice (5.2 ± 0.2 versus 4.18 ± 0.3 ng/mg wet wt, P = 0.03). Plasma copper was significantly correlated with brain copper in mice (R2 = 0.218; P = 0.038). Among human subjects with AD, both plasma copper (1284 ± 118 versus 853 ± 81 ng/mL, P = 0.005) and cerebrospinal fluid copper (12.8 ± 1 versus 10.4 ± 0.7 ng/mL, P = 0.01) were elevated in women compared to men. Among healthy control subjects, plasma copper (1008 ± 51 versus 836 ± 41 ng/mL; P = 0.01) was higher in women than in men, but there was no difference in cerebrospinal fluid copper. We conclude that gender differences in copper status may influence copper-mediated pathological events in the brain.

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