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Bisphenol A exposure promotes HTR-8/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-β1 and MMP-9 and stimulation of MAPK and PI3K signaling pathways.

Oncotarget

Lan X, Fu LJ, Zhang J, Liu XQ, Zhang HJ, Zhang X, Ma MF, Chen XM, He JL, Li LB, Wang YX, Ding YB.
PMID: 28881663
Oncotarget. 2017 May 16;8(31):51507-51521. doi: 10.18632/oncotarget.17882. eCollection 2017 Aug 01.

In this study, we investigated the effect of Bisphenol A (BPA), an endocrine-disrupting chemical, on the migration of human trophoblasts and mouse placentation by using the primary extravillous trophoblast (EVT) and its cell line HTR-8/SVneo, villous explant cultures, and...

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Lan X, Fu LJ, Zhang J, et al. Bisphenol A exposure promotes HTR-8/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-β1 and MMP-9 and stimulation of MAPK and PI3K signaling pathways. Oncotarget. 2017;8(31):51507-51521doi: 10.18632/oncotarget.17882.
Lan, X., Fu, L. J., Zhang, J., Liu, X. Q., Zhang, H. J., Zhang, X., Ma, M. F., Chen, X. M., He, J. L., Li, L. B., Wang, Y. X., & Ding, Y. B. (2017). Bisphenol A exposure promotes HTR-8/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-β1 and MMP-9 and stimulation of MAPK and PI3K signaling pathways. Oncotarget, 8(31), 51507-51521. https://doi.org/10.18632/oncotarget.17882
Lan, Xi, et al. "Bisphenol A exposure promotes HTR-8/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-β1 and MMP-9 and stimulation of MAPK and PI3K signaling pathways." Oncotarget vol. 8,31 (2017): 51507-51521. doi: https://doi.org/10.18632/oncotarget.17882
Lan X, Fu LJ, Zhang J, Liu XQ, Zhang HJ, Zhang X, Ma MF, Chen XM, He JL, Li LB, Wang YX, Ding YB. Bisphenol A exposure promotes HTR-8/SVneo cell migration and impairs mouse placentation involving upregulation of integrin-β1 and MMP-9 and stimulation of MAPK and PI3K signaling pathways. Oncotarget. 2017 May 16;8(31):51507-51521. doi: 10.18632/oncotarget.17882. eCollection 2017 Aug 01. PMID: 28881663; PMCID: PMC5584264.
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Control of host cell phosphorylation by legionella pneumophila.

Frontiers in microbiology

Haenssler E, Isberg RR.
PMID: 21747787
Front Microbiol. 2011 Apr 04;2:64. doi: 10.3389/fmicb.2011.00064. eCollection 2011.

Phosphorylation is one of the most frequent modifications in intracellular signaling and is implicated in many processes ranging from transcriptional control to signal transduction in innate immunity. Many pathogens modulate host cell phosphorylation pathways to promote growth and establish...

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Haenssler E, Isberg RR. Control of host cell phosphorylation by legionella pneumophila. Front Microbiol. 2011;2:64doi: 10.3389/fmicb.2011.00064.
Haenssler, E., & Isberg, R. R. (2011). Control of host cell phosphorylation by legionella pneumophila. Frontiers in microbiology, 264. https://doi.org/10.3389/fmicb.2011.00064
Haenssler, Eva, and Isberg, Ralph R. "Control of host cell phosphorylation by legionella pneumophila." Frontiers in microbiology vol. 2 (2011): 64. doi: https://doi.org/10.3389/fmicb.2011.00064
Haenssler E, Isberg RR. Control of host cell phosphorylation by legionella pneumophila. Front Microbiol. 2011 Apr 04;2:64. doi: 10.3389/fmicb.2011.00064. eCollection 2011. PMID: 21747787; PMCID: PMC3128975.
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Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells.

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Jeong HJ, Kim JH, Jeon S.
PMID: 21994482
Korean J Physiol Pharmacol. 2011 Aug;15(4):245-9. doi: 10.4196/kjpp.2011.15.4.245. Epub 2011 Aug 31.

Amphetamine, a synthetic psychostimulant, is transported by the dopamine transporter (DAT) to the cytosol and increases the exchange of extracellular amphetamine by intracellular dopamine. Recently, we reported that the phosphorylation levels of ezrin-radixin-moesin (ERM) proteins are regulated by psychostimulant...

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Jeong HJ, Kim JH, Jeon S. Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells. Korean J Physiol Pharmacol. 2011;15(4):245-9doi: 10.4196/kjpp.2011.15.4.245.
Jeong, H. J., Kim, J. H., & Jeon, S. (2011). Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 15(4), 245-9. https://doi.org/10.4196/kjpp.2011.15.4.245
Jeong, Ha Jin, et al. "Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 15,4 (2011): 245-9. doi: https://doi.org/10.4196/kjpp.2011.15.4.245
Jeong HJ, Kim JH, Jeon S. Amphetamine-induced ERM Proteins Phosphorylation Is through PKCβ Activation in PC12 Cells. Korean J Physiol Pharmacol. 2011 Aug;15(4):245-9. doi: 10.4196/kjpp.2011.15.4.245. Epub 2011 Aug 31. PMID: 21994482; PMCID: PMC3186925.
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Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells.

Frontiers in neuroscience

Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth T.
PMID: 23430930
Front Neurosci. 2013 Feb 20;7:16. doi: 10.3389/fnins.2013.00016. eCollection 2013.

Gene expression profiling was performed on the human neuroglial cell line T98G after treatment with adaptogen ADAPT-232 and its constituents - extracts of Eleutherococcus senticosus root, Schisandra chinensis berry, and Rhodiola rosea root as well as several constituents individually,...

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Panossian A, Hamm R, Kadioglu O, et al. Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells. Front Neurosci. 2013;7:16doi: 10.3389/fnins.2013.00016.
Panossian, A., Hamm, R., Kadioglu, O., Wikman, G., & Efferth, T. (2013). Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells. Frontiers in neuroscience, 716. https://doi.org/10.3389/fnins.2013.00016
Panossian, Alexander, et al. "Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells." Frontiers in neuroscience vol. 7 (2013): 16. doi: https://doi.org/10.3389/fnins.2013.00016
Panossian A, Hamm R, Kadioglu O, Wikman G, Efferth T. Synergy and Antagonism of Active Constituents of ADAPT-232 on Transcriptional Level of Metabolic Regulation of Isolated Neuroglial Cells. Front Neurosci. 2013 Feb 20;7:16. doi: 10.3389/fnins.2013.00016. eCollection 2013. PMID: 23430930; PMCID: PMC3576868.
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PI3K Pathway in NSCLC.

Frontiers in oncology

Martinez-Martí A, Felip E.
PMID: 22655251
Front Oncol. 2012 Jan 06;1:55. doi: 10.3389/fonc.2011.00055. eCollection 2011.

The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3'-hydroxyl group of phosphatidylinositol and phosphoinositides. PI3K regulate signaling pathways for neoplasia, including cell proliferation, adhesion, survival, and motility. Different classes of PI3K...

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Martinez-Martí A, Felip E. PI3K Pathway in NSCLC. Front Oncol. 2012;1:55doi: 10.3389/fonc.2011.00055.
Martinez-Martí, A., & Felip, E. (2011). PI3K Pathway in NSCLC. Frontiers in oncology, 155. https://doi.org/10.3389/fonc.2011.00055
Martinez-Martí, Alex, and Felip, Enriqueta. "PI3K Pathway in NSCLC." Frontiers in oncology vol. 1 (2011): 55. doi: https://doi.org/10.3389/fonc.2011.00055
Martinez-Martí A, Felip E. PI3K Pathway in NSCLC. Front Oncol. 2012 Jan 06;1:55. doi: 10.3389/fonc.2011.00055. eCollection 2011. PMID: 22655251; PMCID: PMC3356073.
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[No title available]

American journal of translational research

Huang D, Tang L, Yang F, Jin J, Guan X.
PMID: 31632573
Am J Transl Res. 2019 Sep 15;11(9):6055-6065. eCollection 2019.

p110α is an important subunit of phosphatidylinositol-3-kinases (PI3Ks) encoded by

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Huang D, Tang L, Yang F, et al. . Am J Transl Res. 2019;11(9):6055-6065
Huang, D., Tang, L., Yang, F., Jin, J., & Guan, X. (2019). . American journal of translational research, 11(9), 6055-6065.
Huang, Doudou, et al. "." American journal of translational research vol. 11,9 (2019): 6055-6065.
Huang D, Tang L, Yang F, Jin J, Guan X. . Am J Transl Res. 2019 Sep 15;11(9):6055-6065. eCollection 2019. PMID: 31632573; PMCID: PMC6789267.
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Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies.

Bioorganic & medicinal chemistry

Kim YS, Cheon MG, Boggu PR, Koh SY, Park GM, Kim G, Park SH, Park SL, Lee CW, Kim JW, Jung YH.
PMID: 34332211
Bioorg Med Chem. 2021 Sep 01;45:116312. doi: 10.1016/j.bmc.2021.116312. Epub 2021 Jul 22.

Phosphatidylinositol 3-kinases (PI3Ks) mediate intracellular signal transduction. Aberrant PI3K signaling is associated with oncogenesis and disease progression in solid tumors and hematologic malignancies. Idelalisib (1), a first-in-class PI3Kδ inhibitor for the treatment of hematologic malignancies, was developed, but its...

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Kim YS, Cheon MG, Boggu PR, et al. Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorg Med Chem. 2021;45:116312doi: 10.1016/j.bmc.2021.116312.
Kim, Y. S., Cheon, M. G., Boggu, P. R., Koh, S. Y., Park, G. M., Kim, G., Park, S. H., Park, S. L., Lee, C. W., Kim, J. W., & Jung, Y. H. (2021). Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorganic & medicinal chemistry, 45116312. https://doi.org/10.1016/j.bmc.2021.116312
Kim, Yeon Su, et al. "Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies." Bioorganic & medicinal chemistry vol. 45 (2021): 116312. doi: https://doi.org/10.1016/j.bmc.2021.116312
Kim YS, Cheon MG, Boggu PR, Koh SY, Park GM, Kim G, Park SH, Park SL, Lee CW, Kim JW, Jung YH. Synthesis and biological evaluation of novel purinyl quinazolinone derivatives as PI3Kδ-specific inhibitors for the treatment of hematologic malignancies. Bioorg Med Chem. 2021 Sep 01;45:116312. doi: 10.1016/j.bmc.2021.116312. Epub 2021 Jul 22. PMID: 34332211.
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Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury.

Brain research

Khan H, Singh A, Thapa K, Garg N, Grewal AK, Singh TG.
PMID: 33662337
Brain Res. 2021 Mar 02;147399. doi: 10.1016/j.brainres.2021.147399. Epub 2021 Mar 02.

The cerebral ischemic reperfusion injury may leads to morbidity and mortality in patients. phosphatidylinositol 3-kinase (PI3K) signaling pathway has been believed to work in association with its downstream targets, other receptors, and pathways that may offer antioxidant, anti-inflammatory, anti-apoptotic...

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Khan H, Singh A, Thapa K, et al. Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain Res. 2021;147399doi: 10.1016/j.brainres.2021.147399.
Khan, H., Singh, A., Thapa, K., Garg, N., Grewal, A. K., & Singh, T. G. (2021). Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain research, 147399. https://doi.org/10.1016/j.brainres.2021.147399
Khan, Heena, et al. "Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury." Brain research vol. (2021): 147399. doi: https://doi.org/10.1016/j.brainres.2021.147399
Khan H, Singh A, Thapa K, Garg N, Grewal AK, Singh TG. Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain Res. 2021 Mar 02;147399. doi: 10.1016/j.brainres.2021.147399. Epub 2021 Mar 02. PMID: 33662337.
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The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance.

Experimental dermatology

Parkman GL, Foth M, Kircher DA, Holmen SL, McMahon M.
PMID: 34717019
Exp Dermatol. 2021 Oct 30; doi: 10.1111/exd.14489. Epub 2021 Oct 30.

Phosphatidylinositol-3'-kinases (PI3Ks) are a family of lipid kinases that phosphorylate the 3' hydroxyl (OH) of the inositol ring of phosphatidylinositides (PI). Through their downstream effectors, PI3K generated lipids (PI3K-lipids hereafter) such as PI(3,4,5)P

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Parkman GL, Foth M, Kircher DA, et al. The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance. Exp Dermatol. 2021;doi: 10.1111/exd.14489.
Parkman, G. L., Foth, M., Kircher, D. A., Holmen, S. L., & McMahon, M. (2021). The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance. Experimental dermatology, . https://doi.org/10.1111/exd.14489
Parkman, Gennie L, et al. "The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance." Experimental dermatology vol. (2021). doi: https://doi.org/10.1111/exd.14489
Parkman GL, Foth M, Kircher DA, Holmen SL, McMahon M. The role of PI3'-lipid signalling in melanoma initiation, progression and maintenance. Exp Dermatol. 2021 Oct 30; doi: 10.1111/exd.14489. Epub 2021 Oct 30. PMID: 34717019.
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In-silico prediction of potential inhibitors against phosphatidylinositol 3-kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas.

Journal of biomolecular structure & dynamics

Madhukar G, Subbarao N.
PMID: 33356909
J Biomol Struct Dyn. 2020 Dec 24;1-16. doi: 10.1080/07391102.2020.1861980. Epub 2020 Dec 24.

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers, globally. Its high mortality rates remained unaltered in the last three decades, therefore, there is an enormous need for novel therapeutics. The most frequent somatically...

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Madhukar G, Subbarao N. In-silico prediction of potential inhibitors against phosphatidylinositol 3-kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas. J Biomol Struct Dyn. 2020;1-16doi: 10.1080/07391102.2020.1861980.
Madhukar, G., & Subbarao, N. (2020). In-silico prediction of potential inhibitors against phosphatidylinositol 3-kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas. Journal of biomolecular structure & dynamics, 1-16. https://doi.org/10.1080/07391102.2020.1861980
Madhukar, Geet, and Subbarao, Naidu. "In-silico prediction of potential inhibitors against phosphatidylinositol 3-kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas." Journal of biomolecular structure & dynamics vol. (2020): 1-16. doi: https://doi.org/10.1080/07391102.2020.1861980
Madhukar G, Subbarao N. In-silico prediction of potential inhibitors against phosphatidylinositol 3-kinase catalytic subunit alpha involved in head and neck squamous cell carcinomas. J Biomol Struct Dyn. 2020 Dec 24;1-16. doi: 10.1080/07391102.2020.1861980. Epub 2020 Dec 24. PMID: 33356909.
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Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells.

Tropical life sciences research

Lua YH, Ong WW, Wong HK, Chew CH.
PMID: 33214856
Trop Life Sci Res. 2020 Oct;31(3):63-75. doi: 10.21315/tlsr2020.31.3.5. Epub 2020 Oct 15.

The metabolism of alcohol involves cytochrome P450 2E1 (CYP2E1)-induced oxidative stress, with the association of phosphatidylinositol-3-kinases (PI3K) and nuclear factor kappa B (NFκB) signalling pathways. CYP2E1 is primarily involved in the microsomal ethanol oxidising system, which generates massive reactive...

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Lua YH, Ong WW, Wong HK, et al. Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells. Trop Life Sci Res. 2020;31(3):63-75doi: 10.21315/tlsr2020.31.3.5.
Lua, Y. H., Ong, W. W., Wong, H. K., & Chew, C. H. (2020). Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells. Tropical life sciences research, 31(3), 63-75. https://doi.org/10.21315/tlsr2020.31.3.5
Lua, Ying-Huan, et al. "Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells." Tropical life sciences research vol. 31,3 (2020): 63-75. doi: https://doi.org/10.21315/tlsr2020.31.3.5
Lua YH, Ong WW, Wong HK, Chew CH. Ethanol-induced CYP2E1 Expression is Reduced by Lauric Acid via PI3K Pathway in HepG2 Cells. Trop Life Sci Res. 2020 Oct;31(3):63-75. doi: 10.21315/tlsr2020.31.3.5. Epub 2020 Oct 15. PMID: 33214856; PMCID: PMC7652244.
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Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells.

Bioengineered

Wang C, Guo J, Wu Z.
PMID: 34666596
Bioengineered. 2021 Dec;12(2):10037-10048. doi: 10.1080/21655979.2021.1994737.

ABBREVIATIONS: TNBC: triple negative breast cancer; ROS: reactive oxygen species; NAC: N-acetyl-L-cysteine; DTX: docetaxel; MAPKs: mitogen-actived protein kinases; PI3K/Akt: phosphatidylinositol 3-kinases (PI3K) /Akt; NF-Κb: the nuclear factor κB (NF-κB).

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Wang C, Guo J, Wu Z. Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells. Bioengineered. 2021;12(2):10037-10048doi: 10.1080/21655979.2021.1994737.
Wang, C., Guo, J., & Wu, Z. (2021). Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells. Bioengineered, 12(2), 10037-10048. https://doi.org/10.1080/21655979.2021.1994737
Wang, Changcheng, et al. "Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells." Bioengineered vol. 12,2 (2021): 10037-10048. doi: https://doi.org/10.1080/21655979.2021.1994737
Wang C, Guo J, Wu Z. Combinative treatment of Curdione and docetaxel triggers reactive oxygen species (ROS)-mediated intrinsic apoptosis of triple-negative breast cancer cells. Bioengineered. 2021 Dec;12(2):10037-10048. doi: 10.1080/21655979.2021.1994737. PMID: 34666596.
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Showing 1 to 12 of 47 entries