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Showing 1 to 12 of 22 entries
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Activation of a Large-conductance Ca2+-Dependent K+ Channel by Stimulation of Glutamate Phosphoinositide-coupled Receptors in Cultured Cerebellar Granule Cells.

The European journal of neuroscience

Fagni L, Bossu JL, Bockaert J.
PMID: 12106464
Eur J Neurosci. 1991;3(8):778-789. doi: 10.1111/j.1460-9568.1991.tb01674.x.

Trans-1-amino-cyclopentyl-1,3-dicarboxylic acid (trans-ACPD), a specific agonist of the glutamate phosphoinositide-coupled receptor (Qp receptor), increased the amplitude of the outward K+ current recorded in the whole-cell configuration of the patch-clamp technique in mouse cultured cerebellar granule cells. This effect was...

Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors.

Evidence-based complementary and alternative medicine : eCAM

Del Valle-Mojica LM, Cordero-Hernández JM, González-Medina G, Ramos-Vélez I, Berríos-Cartagena N, Torres-Hernández BA, Ortíz JG.
PMID: 21151614
Evid Based Complement Alternat Med. 2011;2011:891819. doi: 10.1155/2011/891819. Epub 2010 Dec 02.

The effects of two valerian extracts (aqueous and hydroalcoholic) were investigated through [(3)H]Glutamate ([(3)H]Glu) and [(3)H]Fluorowillardine ([(3)H]FW) receptor binding assays using rat synaptic membranes in presence of different receptor ligands. In addition, the extract stability was monitored spectrophotometrically. Both...

Possible interaction of [(3)H]glutamate binding sites with anion channels in rat neural tissues.

Neurochemistry international

Yoneda Y, Ogita K, Nakamuta H, Koida M, Ohgaki T, Meguri H.
PMID: 20493157
Neurochem Int. 1986;9(4):521-31. doi: 10.1016/0197-0186(86)90145-2.

The effect of various ions on [(3)H]l-glutamic acid (Glu) binding was examined using crude synaptic membrane preparations from the rat brain. In vitro addition of sodium acetate (1-100 mM) exhibited a significant enhancement of the binding in a concentration...

The polyamines, spermine and spermidine, negatively modulate N-methyl-d-aspartate (NMDA) and quisqualate receptor mediated responses in vivo : Cerebellar cyclic GMP measurements.

Neurochemistry international

Rao TS, Cler JA, Oei EJ, Emmett MR, Mick SJ, Iyengar S, Wood PL.
PMID: 20504558
Neurochem Int. 1990;16(2):199-206. doi: 10.1016/0197-0186(90)90088-b.

The effects of the polyamines, spermine and spermidine on basal and d-serine-, harmaline- and quisqualate-induced cyclic GMP (cGMP) were measured in mouse cerebellum. Spermine and spermidine at 200 ?g/mouse, intracerebellar injection (icb), did not alter basal cGMP levels. d-Serine...

Characterization of an antiserum to glycyl-d-aspartate (GDA) and its use as a probe for endogenous N-methyl-d-aspartate (NMDA)-like compounds.

Molecular and cellular neurosciences

Ordronneau P, Woodley JC, Grossman G, Abdullah LH, Lazarus LH, Petrusz P.
PMID: 19912868
Mol Cell Neurosci. 1992 Jun;3(3):259-66. doi: 10.1016/1044-7431(92)90046-5.

The long-term goal of this study is to identify endogenous N-methyl-d-aspartate (NMDA)-like compounds with the help of antibodies. Since NMDA contains a blocked amino group, it cannot be conjugated with glutaraldehyde to a carrier protein for immunization. Thus, we...

Pharmacology of excitatory amino acid receptors coupled to inositol phosphate metabolism in neonatal rat striatum.

Neurochemistry international

Doble A, Perrier ML.
PMID: 20504458
Neurochem Int. 1989;15(1):1-8. doi: 10.1016/0197-0186(89)90069-7.

The production of inositol phosphate from tritiated inositol was studied in striatal slices of neonatal rats. The excitatory amino acids glutamic, aspartic, quisqualic and ibotenic acids directly stimulated the formation of inositol phosphate in this system. The receptor mediating...

Glutamate excitatory effects on ampullar receptors of the frog.

Amino acids

Prigioni I, Russo G.
PMID: 24178842
Amino Acids. 1995 Sep;9(3):265-73. doi: 10.1007/BF00805957.

The action of glutamate on frog ampullar receptors was investigated to assess the potential role of this excitatory amino acid as an afferent transmitter in the hair cell system. Intracellular recordings from single afferent units in the isolated labyrinth...

The Discovery and Characterization of Targeted Perikaryal-Specific Brain Lesions With Excitotoxins.

Frontiers in neuroscience

Coyle JT, Schwarcz R.
PMID: 33013307
Front Neurosci. 2020 Sep 08;14:927. doi: 10.3389/fnins.2020.00927. eCollection 2020.

The neurotoxic action of glutamic acid was first described by Lucas and Newhouse, who demonstrated neural degeneration in the inner layers of the neonatal mouse retina after systemic treatment with L-glutamate. Olney extended these findings by showing that neuronal...

Comparison of radial maze performance of rats after ibotenate and quisqualate lesions of the forebrain cholinergic projection system: effects of pharmacological challenge and changes in training regime.

Behavioural pharmacology

Turner JJ, Hodges H, Sinden JD, Gray JA.
PMID: 11224138
Behav Pharmacol. 1992 Aug;3(4):359-73.

Rats with ibotenic or quisqualic acid lesions to cholinergic projections showed similar significant increases in both short-term working and long-term reference memory errors in radial maze spatial (place) and nonspatial (cue) tasks, throughout a period of 10 weeks after...

Conditions affecting the onset, severity, and progression of a spontaneous pain-like behavior after excitotoxic spinal cord injury.

The journal of pain

Gorman AL, Yu CG, Ruenes GR, Daniels L, Yezierski RP.
PMID: 14622821
J Pain. 2001 Aug;2(4):229-40. doi: 10.1054/jpai.2001.22788.

Intraspinal injection of quisqualic acid (QUIS) is associated with the development of spontaneous excessive grooming behavior in male Sprague Dawley rats. To further characterize this pain-like behavior we evaluated the relationship between the onset of this behavior and the...

Characterization of [(3)H]glutamate binding sites on frozen sections from rat adrenal.

Neurochemistry international

Nakamuta H, Ogita K, Fukuda Y, Koida M, Yoneda Y.
PMID: 20501132
Neurochem Int. 1987;10(4):565-70. doi: 10.1016/0197-0186(87)90086-6.

Some biochemical characteristics of [(3)H]glutamate (Glu) binding sites on frozen sections from the rat adrenal glands were studied. Adrenal frozen sections exhibited stereo-selective, saturable and temperature-dependent binding of [(3)H]Glu. An agonist for one of the subclasses of central Glu...

The effect of non-NMDA antagonists and phorbol esters on excitatory amino acid stimulated inositol phosphate formation in rat cerebral cortex.

Neurochemistry international

Godfrey PP, Taghavi Z.
PMID: 20504541
Neurochem Int. 1990;16(1):65-72. doi: 10.1016/0197-0186(90)90124-c.

The effects of various modulators of excitatory amino acid stimulated inositol phosphate (IP) formation were investigated in slices of rat cerebral cortex. Both quisqualic acid (Quis) and ibotenic acid (Ibo) stimulated IP formation in a dose-dependent manner. Quis (0.3mM)...

Showing 1 to 12 of 22 entries