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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
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NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
Copy Download .nbib Format: NLM
NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
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Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells.

Cell reports

McLane LM, Ngiow SF, Chen Z, Attanasio J, Manne S, Ruthel G, Wu JE, Staupe RP, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Freedman BD, Betts MR, Wherry EJ.
PMID: 33979613
Cell Rep. 2021 May 11;35(6):109120. doi: 10.1016/j.celrep.2021.109120.

The transcription factors T-bet and Eomesodermin (Eomes) regulate CD8 T cell exhaustion through undefined mechanisms. Here, we show that the subcellular localization of T-bet and Eomes dictate their regulatory activity in exhausted T cells (T

Cite
McLane LM, Ngiow SF, Chen Z, et al. Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. Cell Rep. 2021;35(6):109120doi: 10.1016/j.celrep.2021.109120.
McLane, L. M., Ngiow, S. F., Chen, Z., Attanasio, J., Manne, S., Ruthel, G., Wu, J. E., Staupe, R. P., Xu, W., Amaravadi, R. K., Xu, X., Karakousis, G. C., Mitchell, T. C., Schuchter, L. M., Huang, A. C., Freedman, B. D., Betts, M. R., & Wherry, E. J. (2021). Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. Cell reports, 35(6), 109120. https://doi.org/10.1016/j.celrep.2021.109120
McLane, Laura M, et al. "Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells." Cell reports vol. 35,6 (2021): 109120. doi: https://doi.org/10.1016/j.celrep.2021.109120
McLane LM, Ngiow SF, Chen Z, Attanasio J, Manne S, Ruthel G, Wu JE, Staupe RP, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Huang AC, Freedman BD, Betts MR, Wherry EJ. Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells. Cell Rep. 2021 May 11;35(6):109120. doi: 10.1016/j.celrep.2021.109120. PMID: 33979613; PMCID: PMC8195461.
Copy Download .nbib Format: NLM
NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy.

The Journal of experimental medicine

Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM.
PMID: 34882194
J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09.

Pregnancy is a common immunization event, but the molecular mechanisms and immunological consequences provoked by pregnancy remain largely unknown. We used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells (Preg-TEX), which...

Cite
Lewis EL, Xu R, Beltra JC, et al. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2021;219(1)doi: 10.1084/jem.20201599.
Lewis, E. L., Xu, R., Beltra, J. C., Ngiow, S. F., Cohen, J., Telange, R., Crane, A., Sawinski, D., Wherry, E. J., & Porrett, P. M. (2022). NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. The Journal of experimental medicine, 219(1), . https://doi.org/10.1084/jem.20201599
Lewis, Emma L, et al. "NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy." The Journal of experimental medicine vol. 219,1 (2022). doi: https://doi.org/10.1084/jem.20201599
Lewis EL, Xu R, Beltra JC, Ngiow SF, Cohen J, Telange R, Crane A, Sawinski D, Wherry EJ, Porrett PM. NFAT-dependent and -independent exhaustion circuits program maternal CD8 T cell hypofunction in pregnancy. J Exp Med. 2022 Jan 03;219(1). doi: 10.1084/jem.20201599. Epub 2021 Dec 09. PMID: 34882194; PMCID: PMC8666877.
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Inhibitory signaling sustains a distinct early memory CD8.

Science immunology

Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, Harly C, Attanasio J, Pauken KE, Bengsch B, Paley MA, Tomov VT, Kurachi M, Vignali DAA, Sharpe AH, Reiner SL, Bhandoola A, Johnson FB, Wherry EJ.
PMID: 33452106
Sci Immunol. 2021 Jan 15;6(55). doi: 10.1126/sciimmunol.abe3702.

The developmental origins of memory T cells remain incompletely understood. During the expansion phase of acute viral infection, we identified a distinct subset of virus-specific CD8

Cite
Johnnidis JB, Muroyama Y, Ngiow SF, et al. Inhibitory signaling sustains a distinct early memory CD8. Sci Immunol. 2021;6(55)doi: 10.1126/sciimmunol.abe3702.
Johnnidis, J. B., Muroyama, Y., Ngiow, S. F., Chen, Z., Manne, S., Cai, Z., Song, S., Platt, J. M., Schenkel, J. M., Abdel-Hakeem, M., Beltra, J. C., Greenplate, A. R., Ali, M. A., Nzingha, K., Giles, J. R., Harly, C., Attanasio, J., Pauken, K. E., Bengsch, B., Paley, M. A., Tomov, V. T., Kurachi, M., Vignali, D. A. A., Sharpe, A. H., Reiner, S. L., Bhandoola, A., Johnson, F. B., & Wherry, E. J. (2021). Inhibitory signaling sustains a distinct early memory CD8. Science immunology, 6(55), . https://doi.org/10.1126/sciimmunol.abe3702
Johnnidis, Jonathan B, et al. "Inhibitory signaling sustains a distinct early memory CD8." Science immunology vol. 6,55 (2021). doi: https://doi.org/10.1126/sciimmunol.abe3702
Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, Harly C, Attanasio J, Pauken KE, Bengsch B, Paley MA, Tomov VT, Kurachi M, Vignali DAA, Sharpe AH, Reiner SL, Bhandoola A, Johnson FB, Wherry EJ. Inhibitory signaling sustains a distinct early memory CD8. Sci Immunol. 2021 Jan 15;6(55). doi: 10.1126/sciimmunol.abe3702. PMID: 33452106; PMCID: PMC8258400.
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Showing 1 to 6 of 6 entries