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Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation.

Molecular metabolism

Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Damania B, Rashid N, Galanko JA, Lee DP, Edin ML, Zeldin DC, Fueger PT, Dietz B, Stahl A, Wu Y, Mohlke KL, Makowski L.
PMID: 27408776
Mol Metab. 2016 Apr 23;5(7):506-526. doi: 10.1016/j.molmet.2016.04.005. eCollection 2016 Jul.

OBJECTIVE: A novel approach to regulate obesity-associated adipose inflammation may be through metabolic reprogramming of macrophages (MΦs). Broadly speaking, MΦs dependent on glucose are pro-inflammatory, classically activated MΦs (CAM), which contribute to adipose inflammation and insulin resistance. In contrast,...

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Johnson AR, Qin Y, Cozzo AJ, et al. Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Mol Metab. 2016;5(7):506-526doi: 10.1016/j.molmet.2016.04.005.
Johnson, A. R., Qin, Y., Cozzo, A. J., Freemerman, A. J., Huang, M. J., Zhao, L., Sampey, B. P., Milner, J. J., Beck, M. A., Damania, B., Rashid, N., Galanko, J. A., Lee, D. P., Edin, M. L., Zeldin, D. C., Fueger, P. T., Dietz, B., Stahl, A., Wu, Y., Mohlke, K. L., & Makowski, L. (2016). Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Molecular metabolism, 5(7), 506-526. https://doi.org/10.1016/j.molmet.2016.04.005
Johnson, Amy R, et al. "Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation." Molecular metabolism vol. 5,7 (2016): 506-526. doi: https://doi.org/10.1016/j.molmet.2016.04.005
Johnson AR, Qin Y, Cozzo AJ, Freemerman AJ, Huang MJ, Zhao L, Sampey BP, Milner JJ, Beck MA, Damania B, Rashid N, Galanko JA, Lee DP, Edin ML, Zeldin DC, Fueger PT, Dietz B, Stahl A, Wu Y, Mohlke KL, Makowski L. Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation. Mol Metab. 2016 Apr 23;5(7):506-526. doi: 10.1016/j.molmet.2016.04.005. eCollection 2016 Jul. PMID: 27408776; PMCID: PMC4921943.
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Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits.

Genome research

Orchard P, Manickam N, Ventresca C, Vadlamudi S, Varshney A, Rai V, Kaplan J, Lalancette C, Mohlke KL, Gallagher K, Burant CF, Parker SCJ.
PMID: 34815310
Genome Res. 2021 Nov 23; doi: 10.1101/gr.268482.120. Epub 2021 Nov 23.

Skeletal muscle accounts for the largest proportion of human body mass, on average, and is a key tissue in complex diseases and mobility. It is composed of several different cell and muscle fiber types. Here, we optimize single-nucleus ATAC-seq...

Cite
Orchard P, Manickam N, Ventresca C, et al. Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome Res. 2021;doi: 10.1101/gr.268482.120.
Orchard, P., Manickam, N., Ventresca, C., Vadlamudi, S., Varshney, A., Rai, V., Kaplan, J., Lalancette, C., Mohlke, K. L., Gallagher, K., Burant, C. F., & Parker, S. C. J. (2021). Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome research, . https://doi.org/10.1101/gr.268482.120
Orchard, Peter, et al. "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits." Genome research vol. (2021). doi: https://doi.org/10.1101/gr.268482.120
Orchard P, Manickam N, Ventresca C, Vadlamudi S, Varshney A, Rai V, Kaplan J, Lalancette C, Mohlke KL, Gallagher K, Burant CF, Parker SCJ. Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome Res. 2021 Nov 23; doi: 10.1101/gr.268482.120. Epub 2021 Nov 23. PMID: 34815310; PMCID: PMC8647829.
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Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits.

Genome research

Orchard P, Manickam N, Ventresca C, Vadlamudi S, Varshney A, Rai V, Kaplan J, Lalancette C, Mohlke KL, Gallagher K, Burant CF, Parker SCJ.
PMID: 34815310
Genome Res. 2021 Nov 23; doi: 10.1101/gr.268482.120. Epub 2021 Nov 23.

Skeletal muscle accounts for the largest proportion of human body mass, on average, and is a key tissue in complex diseases and mobility. It is composed of several different cell and muscle fiber types. Here, we optimize single-nucleus ATAC-seq...

Cite
Orchard P, Manickam N, Ventresca C, et al. Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome Res. 2021;doi: 10.1101/gr.268482.120.
Orchard, P., Manickam, N., Ventresca, C., Vadlamudi, S., Varshney, A., Rai, V., Kaplan, J., Lalancette, C., Mohlke, K. L., Gallagher, K., Burant, C. F., & Parker, S. C. J. (2021). Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome research, . https://doi.org/10.1101/gr.268482.120
Orchard, Peter, et al. "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits." Genome research vol. (2021). doi: https://doi.org/10.1101/gr.268482.120
Orchard P, Manickam N, Ventresca C, Vadlamudi S, Varshney A, Rai V, Kaplan J, Lalancette C, Mohlke KL, Gallagher K, Burant CF, Parker SCJ. Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome Res. 2021 Nov 23; doi: 10.1101/gr.268482.120. Epub 2021 Nov 23. PMID: 34815310; PMCID: PMC8647829.
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Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes.

Genome medicine

Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P.
PMID: 34340684
Genome Med. 2021 Aug 02;13(1):123. doi: 10.1186/s13073-021-00939-2.

BACKGROUND: Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has been estimated using waist-hip ratio (WHR). Waist-hip ratio...

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Pan DZ, Miao Z, Comenho C, et al. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021;13(1):123doi: 10.1186/s13073-021-00939-2.
Pan, D. Z., Miao, Z., Comenho, C., Rajkumar, S., Koka, A., Lee, S. H. T., Alvarez, M., Kaminska, D., Ko, A., Sinsheimer, J. S., Mohlke, K. L., Mancuso, N., Muñoz-Hernandez, L. L., Herrera-Hernandez, M., Tusié-Luna, M. T., Aguilar-Salinas, C., Pietiläinen, K. H., Pihlajamäki, J., Laakso, M., Garske, K. M., & Pajukanta, P. (2021). Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome medicine, 13(1), 123. https://doi.org/10.1186/s13073-021-00939-2
Pan, David Z, et al. "Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes." Genome medicine vol. 13,1 (2021): 123. doi: https://doi.org/10.1186/s13073-021-00939-2
Pan DZ, Miao Z, Comenho C, Rajkumar S, Koka A, Lee SHT, Alvarez M, Kaminska D, Ko A, Sinsheimer JS, Mohlke KL, Mancuso N, Muñoz-Hernandez LL, Herrera-Hernandez M, Tusié-Luna MT, Aguilar-Salinas C, Pietiläinen KH, Pihlajamäki J, Laakso M, Garske KM, Pajukanta P. Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes. Genome Med. 2021 Aug 02;13(1):123. doi: 10.1186/s13073-021-00939-2. PMID: 34340684; PMCID: PMC8327600.
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Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults.

Circulation. Genomic and precision medicine

Olson NC, Raffield LM, Moxley AH, Miller-Fleming TW, Auer PL, Franceschini N, Ngo D, Thornton TA, Lange EM, Li Y, Nickerson DA, Zakai NA, Gerszten RE, Cox NJ, Correa A, Mohlke KL, Reiner AP.
PMID: 34706549
Circ Genom Precis Med. 2021 Dec;14(6):e003421. doi: 10.1161/CIRCGEN.121.003421. Epub 2021 Oct 28.

BACKGROUND: suPAR (Soluble urokinase plasminogen activator receptor) has emerged as an important biomarker of coagulation, inflammation, and cardiovascular disease (CVD) risk. The contribution of suPAR to CVD risk and its genetic influence in Black populations have not been evaluated.METHODS:...

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Olson NC, Raffield LM, Moxley AH, et al. Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circ Genom Precis Med. 2021;14(6):e003421doi: 10.1161/CIRCGEN.121.003421.
Olson, N. C., Raffield, L. M., Moxley, A. H., Miller-Fleming, T. W., Auer, P. L., Franceschini, N., Ngo, D., Thornton, T. A., Lange, E. M., Li, Y., Nickerson, D. A., Zakai, N. A., Gerszten, R. E., Cox, N. J., Correa, A., Mohlke, K. L., & Reiner, A. P. (2021). Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circulation. Genomic and precision medicine, 14(6), e003421. https://doi.org/10.1161/CIRCGEN.121.003421
Olson, Nels C, et al. "Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults." Circulation. Genomic and precision medicine vol. 14,6 (2021): e003421. doi: https://doi.org/10.1161/CIRCGEN.121.003421
Olson NC, Raffield LM, Moxley AH, Miller-Fleming TW, Auer PL, Franceschini N, Ngo D, Thornton TA, Lange EM, Li Y, Nickerson DA, Zakai NA, Gerszten RE, Cox NJ, Correa A, Mohlke KL, Reiner AP. Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circ Genom Precis Med. 2021 Dec;14(6):e003421. doi: 10.1161/CIRCGEN.121.003421. Epub 2021 Oct 28. PMID: 34706549; PMCID: PMC8692389.
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Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults.

Circulation. Genomic and precision medicine

Olson NC, Raffield LM, Moxley AH, Miller-Fleming TW, Auer PL, Franceschini N, Ngo D, Thornton TA, Lange EM, Li Y, Nickerson DA, Zakai NA, Gerszten RE, Cox NJ, Correa A, Mohlke KL, Reiner AP.
PMID: 34706549
Circ Genom Precis Med. 2021 Dec;14(6):e003421. doi: 10.1161/CIRCGEN.121.003421. Epub 2021 Oct 28.

BACKGROUND: suPAR (Soluble urokinase plasminogen activator receptor) has emerged as an important biomarker of coagulation, inflammation, and cardiovascular disease (CVD) risk. The contribution of suPAR to CVD risk and its genetic influence in Black populations have not been evaluated.METHODS:...

Cite
Olson NC, Raffield LM, Moxley AH, et al. Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circ Genom Precis Med. 2021;14(6):e003421doi: 10.1161/CIRCGEN.121.003421.
Olson, N. C., Raffield, L. M., Moxley, A. H., Miller-Fleming, T. W., Auer, P. L., Franceschini, N., Ngo, D., Thornton, T. A., Lange, E. M., Li, Y., Nickerson, D. A., Zakai, N. A., Gerszten, R. E., Cox, N. J., Correa, A., Mohlke, K. L., & Reiner, A. P. (2021). Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circulation. Genomic and precision medicine, 14(6), e003421. https://doi.org/10.1161/CIRCGEN.121.003421
Olson, Nels C, et al. "Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults." Circulation. Genomic and precision medicine vol. 14,6 (2021): e003421. doi: https://doi.org/10.1161/CIRCGEN.121.003421
Olson NC, Raffield LM, Moxley AH, Miller-Fleming TW, Auer PL, Franceschini N, Ngo D, Thornton TA, Lange EM, Li Y, Nickerson DA, Zakai NA, Gerszten RE, Cox NJ, Correa A, Mohlke KL, Reiner AP. Soluble Urokinase Plasminogen Activator Receptor: Genetic Variation and Cardiovascular Disease Risk in Black Adults. Circ Genom Precis Med. 2021 Dec;14(6):e003421. doi: 10.1161/CIRCGEN.121.003421. Epub 2021 Oct 28. PMID: 34706549; PMCID: PMC8692389.
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Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits.

Genome research

Orchard P, Manickam N, Ventresca C, Vadlamudi S, Varshney A, Rai V, Kaplan J, Lalancette C, Mohlke KL, Gallagher K, Burant CF, Parker SCJ.
PMID: 34815310
Genome Res. 2021 Nov 23; doi: 10.1101/gr.268482.120. Epub 2021 Nov 23.

Skeletal muscle accounts for the largest proportion of human body mass, on average, and is a key tissue in complex diseases and mobility. It is composed of several different cell and muscle fiber types. Here, we optimize single-nucleus ATAC-seq...

Cite
Orchard P, Manickam N, Ventresca C, et al. Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome Res. 2021;doi: 10.1101/gr.268482.120.
Orchard, P., Manickam, N., Ventresca, C., Vadlamudi, S., Varshney, A., Rai, V., Kaplan, J., Lalancette, C., Mohlke, K. L., Gallagher, K., Burant, C. F., & Parker, S. C. J. (2021). Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome research, . https://doi.org/10.1101/gr.268482.120
Orchard, Peter, et al. "Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits." Genome research vol. (2021). doi: https://doi.org/10.1101/gr.268482.120
Orchard P, Manickam N, Ventresca C, Vadlamudi S, Varshney A, Rai V, Kaplan J, Lalancette C, Mohlke KL, Gallagher K, Burant CF, Parker SCJ. Human and rat skeletal muscle single-nuclei multi-omic integrative analyses nominate causal cell types, regulatory elements, and SNPs for complex traits. Genome Res. 2021 Nov 23; doi: 10.1101/gr.268482.120. Epub 2021 Nov 23. PMID: 34815310; PMCID: PMC8647829.
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Showing 1 to 7 of 7 entries