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Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Diabetologia

Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM.
PMID: 34951656
Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24.

AIMS/HYPOTHESIS: Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbAMETHODS: We conducted a GWAS of fasting glucose (n = 52,267), fasting insulin (n = 48,395) and HbARESULTS: Four...

Cite
Downie CG, Dimos SF, Bien SA, et al. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021;doi: 10.1007/s00125-021-05635-9.
Downie, C. G., Dimos, S. F., Bien, S. A., Hu, Y., Darst, B. F., Polfus, L. M., Wang, Y., Wojcik, G. L., Tao, R., Raffield, L. M., Armstrong, N. D., Polikowsky, H. G., Below, J. E., Correa, A., Irvin, M. R., Rasmussen-Torvik, L. J. F., Carlson, C. S., Phillips, L. S., Liu, S., Pankow, J. S., Rich, S. S., Rotter, J. I., Buyske, S., Matise, T. C., North, K. E., Avery, C. L., Haiman, C. A., Loos, R. J. F., Kooperberg, C., Graff, M., & Highland, H. M. (2021). Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia, . https://doi.org/10.1007/s00125-021-05635-9
Downie, Carolina G, et al. "Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study." Diabetologia vol. (2021). doi: https://doi.org/10.1007/s00125-021-05635-9
Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24. PMID: 34951656.
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Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.

Diabetologia

Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM.
PMID: 34951656
Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24.

AIMS/HYPOTHESIS: Type 2 diabetes is a growing global public health challenge. Investigating quantitative traits, including fasting glucose, fasting insulin and HbAMETHODS: We conducted a GWAS of fasting glucose (n = 52,267), fasting insulin (n = 48,395) and HbARESULTS: Four...

Cite
Downie CG, Dimos SF, Bien SA, et al. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021;doi: 10.1007/s00125-021-05635-9.
Downie, C. G., Dimos, S. F., Bien, S. A., Hu, Y., Darst, B. F., Polfus, L. M., Wang, Y., Wojcik, G. L., Tao, R., Raffield, L. M., Armstrong, N. D., Polikowsky, H. G., Below, J. E., Correa, A., Irvin, M. R., Rasmussen-Torvik, L. J. F., Carlson, C. S., Phillips, L. S., Liu, S., Pankow, J. S., Rich, S. S., Rotter, J. I., Buyske, S., Matise, T. C., North, K. E., Avery, C. L., Haiman, C. A., Loos, R. J. F., Kooperberg, C., Graff, M., & Highland, H. M. (2021). Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia, . https://doi.org/10.1007/s00125-021-05635-9
Downie, Carolina G, et al. "Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study." Diabetologia vol. (2021). doi: https://doi.org/10.1007/s00125-021-05635-9
Downie CG, Dimos SF, Bien SA, Hu Y, Darst BF, Polfus LM, Wang Y, Wojcik GL, Tao R, Raffield LM, Armstrong ND, Polikowsky HG, Below JE, Correa A, Irvin MR, Rasmussen-Torvik LJF, Carlson CS, Phillips LS, Liu S, Pankow JS, Rich SS, Rotter JI, Buyske S, Matise TC, North KE, Avery CL, Haiman CA, Loos RJF, Kooperberg C, Graff M, Highland HM. Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study. Diabetologia. 2021 Dec 24; doi: 10.1007/s00125-021-05635-9. Epub 2021 Dec 24. PMID: 34951656.
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GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations.

Current genetic medicine reports

Chen HH, Petty LE, Bush W, Naj AC, Below JE.
PMID: 33312764
Curr Genet Med Rep. 2019 Mar;7(1):30-40. doi: 10.1007/s40142-019-0159-z. Epub 2019 Feb 14.

PURPOSE OF REVIEW: Neurodegenerative diseases, neuropsychiatric disorders, and related traits have highly complex etiologies but are also highly heritable and identifying the causal genes and biological pathways underlying these traits may advance the development of treatments and preventive strategies....

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Chen HH, Petty LE, Bush W, et al. GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations. Curr Genet Med Rep. 2019;7(1):30-40doi: 10.1007/s40142-019-0159-z.
Chen, H. H., Petty, L. E., Bush, W., Naj, A. C., & Below, J. E. (2019). GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations. Current genetic medicine reports, 7(1), 30-40. https://doi.org/10.1007/s40142-019-0159-z
Chen, Hung-Hsin, et al. "GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations." Current genetic medicine reports vol. 7,1 (2019): 30-40. doi: https://doi.org/10.1007/s40142-019-0159-z
Chen HH, Petty LE, Bush W, Naj AC, Below JE. GWAS and Beyond: Using Omics Approaches to Interpret SNP Associations. Curr Genet Med Rep. 2019 Mar;7(1):30-40. doi: 10.1007/s40142-019-0159-z. Epub 2019 Feb 14. PMID: 33312764; PMCID: PMC7731888.
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The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.

JAMA psychiatry

Giannakopoulou O, Lin K, Meng X, Su MH, Kuo PH, Peterson RE, Awasthi S, Moscati A, Coleman JRI, Bass N, Millwood IY, Chen Y, Chen Z, Chen HC, Lu ML, Huang MC, Chen CH, Stahl EA, Loos RJF, Mullins N, Ursano RJ, Kessler RC, Stein MB, Sen S, Scott LJ, Burmeister M, Fang Y, Tyrrell J, Jiang Y, Tian C, McIntosh AM, Ripke S, Dunn EC, Kendler KS, Walters RG, Lewis CM, Kuchenbaecker K.
PMID: 34586374
JAMA Psychiatry. 2021 Nov 01;78(11):1258-1269. doi: 10.1001/jamapsychiatry.2021.2099.

IMPORTANCE: Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations.OBJECTIVE: To investigate...

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Giannakopoulou O, Lin K, Meng X, et al. The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. JAMA Psychiatry. 2021;78(11):1258-1269doi: 10.1001/jamapsychiatry.2021.2099.
Giannakopoulou, O., Lin, K., Meng, X., Su, M. H., Kuo, P. H., Peterson, R. E., Awasthi, S., Moscati, A., Coleman, J. R. I., Bass, N., Millwood, I. Y., Chen, Y., Chen, Z., Chen, H. C., Lu, M. L., Huang, M. C., Chen, C. H., Stahl, E. A., Loos, R. J. F., Mullins, N., Ursano, R. J., Kessler, R. C., Stein, M. B., Sen, S., Scott, L. J., Burmeister, M., Fang, Y., Tyrrell, J., Jiang, Y., Tian, C., McIntosh, A. M., Ripke, S., Dunn, E. C., Kendler, K. S., Walters, R. G., Lewis, C. M., Kuchenbaecker, K. (2021). The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. JAMA psychiatry, 78(11), 1258-1269. https://doi.org/10.1001/jamapsychiatry.2021.2099
Giannakopoulou, Olga, et al. "The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study." JAMA psychiatry vol. 78,11 (2021): 1258-1269. doi: https://doi.org/10.1001/jamapsychiatry.2021.2099
Giannakopoulou O, Lin K, Meng X, Su MH, Kuo PH, Peterson RE, Awasthi S, Moscati A, Coleman JRI, Bass N, Millwood IY, Chen Y, Chen Z, Chen HC, Lu ML, Huang MC, Chen CH, Stahl EA, Loos RJF, Mullins N, Ursano RJ, Kessler RC, Stein MB, Sen S, Scott LJ, Burmeister M, Fang Y, Tyrrell J, Jiang Y, Tian C, McIntosh AM, Ripke S, Dunn EC, Kendler KS, Walters RG, Lewis CM, Kuchenbaecker K. The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study. JAMA Psychiatry. 2021 Nov 01;78(11):1258-1269. doi: 10.1001/jamapsychiatry.2021.2099. PMID: 34586374; PMCID: PMC8482304.
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Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.

Human molecular genetics

Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE.
PMID: 34165540
Hum Mol Genet. 2021 Nov 01;30(22):2190-2204. doi: 10.1093/hmg/ddab166.

Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central...

Cite
Justice AE, Young K, Gogarten SM, et al. Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL. Hum Mol Genet. 2021;30(22):2190-2204doi: 10.1093/hmg/ddab166.
Justice, A. E., Young, K., Gogarten, S. M., Sofer, T., Graff, M., Love, S. A. M., Wang, Y., Klimentidis, Y. C., Cruz, M., Guo, X., Hartwig, F., Petty, L., Yao, J., Allison, M. A., Below, J. E., Buchanan, T. A., Chen, Y. I., Goodarzi, M. O., Hanis, C., Highland, H. M., Hsueh, W. A., Ipp, E., Parra, E., Palmas, W., Raffel, L. J., Rotter, J. I., Tan, J., Taylor, K. D., Valladares, A., Xiang, A. H., Sánchez-Johnsen, L., Isasi, C. R., & North, K. E. (2021). Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL. Human molecular genetics, 30(22), 2190-2204. https://doi.org/10.1093/hmg/ddab166
Justice, Anne E, et al. "Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL." Human molecular genetics vol. 30,22 (2021): 2190-2204. doi: https://doi.org/10.1093/hmg/ddab166
Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE. Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL. Hum Mol Genet. 2021 Nov 01;30(22):2190-2204. doi: 10.1093/hmg/ddab166. PMID: 34165540; PMCID: PMC8561424.
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Revisiting Some Useful Statistical Guidelines in .

Circulation research

Highland HM, Gamazon ER, Below JE.
PMID: 34032508
Circ Res. 2021 May 28;128(11):1724-1727. doi: 10.1161/CIRCRESAHA.120.317360. Epub 2021 May 25.

No abstract available.

Cite
Highland HM, Gamazon ER, Below JE. Revisiting Some Useful Statistical Guidelines in . Circ Res. 2021;128(11):1724-1727doi: 10.1161/CIRCRESAHA.120.317360.
Highland, H. M., Gamazon, E. R., & Below, J. E. (2021). Revisiting Some Useful Statistical Guidelines in . Circulation research, 128(11), 1724-1727. https://doi.org/10.1161/CIRCRESAHA.120.317360
Highland, Heather M, et al. "Revisiting Some Useful Statistical Guidelines in ." Circulation research vol. 128,11 (2021): 1724-1727. doi: https://doi.org/10.1161/CIRCRESAHA.120.317360
Highland HM, Gamazon ER, Below JE. Revisiting Some Useful Statistical Guidelines in . Circ Res. 2021 May 28;128(11):1724-1727. doi: 10.1161/CIRCRESAHA.120.317360. Epub 2021 May 25. PMID: 34032508; PMCID: PMC8202354.
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Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents.

Pediatric research

Kim D, Justice AE, Chittoor G, Blanco E, Burrows R, Graff M, Howard AG, Wang Y, Rohde R, Buchanan VL, Voruganti VS, Almeida M, Peralta J, Lehman DM, Curran JE, Comuzzie AG, Duggirala R, Blangero J, Albala C, Santos JL, Angel B, Lozoff B, Gahagan S, North KE.
PMID: 34645953
Pediatr Res. 2021 Oct 13; doi: 10.1038/s41390-021-01729-7. Epub 2021 Oct 13.

BACKGROUND: Metabolic regulation plays a significant role in energy homeostasis, and adolescence is a crucial life stage for the development of cardiometabolic disease (CMD). This study aims to investigate the genetic determinants of metabolic biomarkers-adiponectin, leptin, ghrelin, and orexin-and...

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Kim D, Justice AE, Chittoor G, et al. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatr Res. 2021;doi: 10.1038/s41390-021-01729-7.
Kim, D., Justice, A. E., Chittoor, G., Blanco, E., Burrows, R., Graff, M., Howard, A. G., Wang, Y., Rohde, R., Buchanan, V. L., Voruganti, V. S., Almeida, M., Peralta, J., Lehman, D. M., Curran, J. E., Comuzzie, A. G., Duggirala, R., Blangero, J., Albala, C., Santos, J. L., Angel, B., Lozoff, B., Gahagan, S., & North, K. E. (2021). Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatric research, . https://doi.org/10.1038/s41390-021-01729-7
Kim, Daeeun, et al. "Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents." Pediatric research vol. (2021). doi: https://doi.org/10.1038/s41390-021-01729-7
Kim D, Justice AE, Chittoor G, Blanco E, Burrows R, Graff M, Howard AG, Wang Y, Rohde R, Buchanan VL, Voruganti VS, Almeida M, Peralta J, Lehman DM, Curran JE, Comuzzie AG, Duggirala R, Blangero J, Albala C, Santos JL, Angel B, Lozoff B, Gahagan S, North KE. Genetic determinants of metabolic biomarkers and their associations with cardiometabolic traits in Hispanic/Latino adolescents. Pediatr Res. 2021 Oct 13; doi: 10.1038/s41390-021-01729-7. Epub 2021 Oct 13. PMID: 34645953.
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Revisiting Some Useful Statistical Guidelines in .

Circulation research

Highland HM, Gamazon ER, Below JE.
PMID: 34032508
Circ Res. 2021 May 28;128(11):1724-1727. doi: 10.1161/CIRCRESAHA.120.317360. Epub 2021 May 25.

No abstract available.

Cite
Highland HM, Gamazon ER, Below JE. Revisiting Some Useful Statistical Guidelines in . Circ Res. 2021;128(11):1724-1727doi: 10.1161/CIRCRESAHA.120.317360.
Highland, H. M., Gamazon, E. R., & Below, J. E. (2021). Revisiting Some Useful Statistical Guidelines in . Circulation research, 128(11), 1724-1727. https://doi.org/10.1161/CIRCRESAHA.120.317360
Highland, Heather M, et al. "Revisiting Some Useful Statistical Guidelines in ." Circulation research vol. 128,11 (2021): 1724-1727. doi: https://doi.org/10.1161/CIRCRESAHA.120.317360
Highland HM, Gamazon ER, Below JE. Revisiting Some Useful Statistical Guidelines in . Circ Res. 2021 May 28;128(11):1724-1727. doi: 10.1161/CIRCRESAHA.120.317360. Epub 2021 May 25. PMID: 34032508; PMCID: PMC8202354.
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Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL.

Human molecular genetics

Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE.
PMID: 34165540
Hum Mol Genet. 2021 Nov 01;30(22):2190-2204. doi: 10.1093/hmg/ddab166.

Central obesity is a leading health concern with a great burden carried by ethnic minority populations, especially Hispanics/Latinos. Genetic factors contribute to the obesity burden overall and to inter-population differences. We aimed to identify the loci associated with central...

Cite
Justice AE, Young K, Gogarten SM, et al. Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL. Hum Mol Genet. 2021;30(22):2190-2204doi: 10.1093/hmg/ddab166.
Justice, A. E., Young, K., Gogarten, S. M., Sofer, T., Graff, M., Love, S. A. M., Wang, Y., Klimentidis, Y. C., Cruz, M., Guo, X., Hartwig, F., Petty, L., Yao, J., Allison, M. A., Below, J. E., Buchanan, T. A., Chen, Y. I., Goodarzi, M. O., Hanis, C., Highland, H. M., Hsueh, W. A., Ipp, E., Parra, E., Palmas, W., Raffel, L. J., Rotter, J. I., Tan, J., Taylor, K. D., Valladares, A., Xiang, A. H., Sánchez-Johnsen, L., Isasi, C. R., & North, K. E. (2021). Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL. Human molecular genetics, 30(22), 2190-2204. https://doi.org/10.1093/hmg/ddab166
Justice, Anne E, et al. "Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL." Human molecular genetics vol. 30,22 (2021): 2190-2204. doi: https://doi.org/10.1093/hmg/ddab166
Justice AE, Young K, Gogarten SM, Sofer T, Graff M, Love SAM, Wang Y, Klimentidis YC, Cruz M, Guo X, Hartwig F, Petty L, Yao J, Allison MA, Below JE, Buchanan TA, Chen YI, Goodarzi MO, Hanis C, Highland HM, Hsueh WA, Ipp E, Parra E, Palmas W, Raffel LJ, Rotter JI, Tan J, Taylor KD, Valladares A, Xiang AH, Sánchez-Johnsen L, Isasi CR, North KE. Genome-wide association study of body fat distribution traits in Hispanics/Latinos from the HCHS/SOL. Hum Mol Genet. 2021 Nov 01;30(22):2190-2204. doi: 10.1093/hmg/ddab166. PMID: 34165540; PMCID: PMC8561424.
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