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Showing 1 to 12 of 2875 entries
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Disseminated intravascular coagulation.

Indian journal of anaesthesia

Venugopal A.
PMID: 25535423
Indian J Anaesth. 2014 Sep;58(5):603-8. doi: 10.4103/0019-5049.144666.

Disseminated intravascular coagulation (DIC) is a reflection of an underlying systemic disorder which affects the coagulation system, simultaneously resulting in pro-coagulant activation, fibrinolytic activation, and consumption coagulopathy and finally may result in organ dysfunction and death. Though septicaemia is...

The biochemical basis of transmembrane signalling by B lymphocyte surface immunoglobulin.

Immunology today

Cambier JC, Monroe JG, Mark Coggeshall K, Ransom JT.
PMID: 25290184
Immunol Today. 1985 Jul;6(7):218-22. doi: 10.1016/0167-5699(85)90038-6.

The specificity of humoral immune responses is determined primarily at the level of antigen interaction with B lymphocytes which express antigen-specific receptor immunoglobulin. When receptor immunoglobulin is crosslinked by antigen or anti-receptor antibodies there isgeneration and transduction of signals...

Examining the predictive accuracy of the novel 3D N-linear algebraic molecular codifications on benchmark datasets.

Journal of cheminformatics

García-Jacas CR, Contreras-Torres E, Marrero-Ponce Y, Pupo-Meriño M, Barigye SJ, Cabrera-Leyva L.
PMID: 26925168
J Cheminform. 2016 Feb 25;8:10. doi: 10.1186/s13321-016-0122-x. eCollection 2016.

BACKGROUND: Recently, novel 3D alignment-free molecular descriptors (also known as QuBiLS-MIDAS) based on two-linear, three-linear and four-linear algebraic forms have been introduced. These descriptors codify chemical information for relations between two, three and four atoms by using several (dis-)similarity...

Dual Anticoagulation in Recurrent Thromboembolic Events with Failure of Monotherapy: A Novel Approach.

Cureus

Chintalacheruvu LM, Bhatty O, Andukuri VG.
PMID: 28924530
Cureus. 2017 Jul 07;9(7):e1444. doi: 10.7759/cureus.1444.

In the last few decades many new anticoagulants (i.e direct thrombin and factor ten inhibitors) have been introduced with efficacy that rivals older drugs in the treatment of venous thromboembolism (VTE). However, for all their success, management of patients...

Regulation of neutrophilic inflammation in lung injury induced by community-acquired pneumonia.

Lancet (London, England)

José R, Williams A, Sulikowski M, Brealey D, Brown J, Chambers R.
PMID: 26312874
Lancet. 2015 Feb 26;385:S52. doi: 10.1016/S0140-6736(15)60367-1.

BACKGROUND: Community-acquired pneumonia is commonly caused by Streptococcus pneumoniae, which is associated with excessive neutrophilic inflammation. The high-affinity thrombin receptor, proteinase-activated receptor 1 (PAR1), has been implicated in mediating the interplay between coagulation and inflammation. However, its role during...

A historical perspective of the biophysics of the thrombin-heparin system: an example of nonspecific binding and the consequent parking problem in action.

Biophysical reviews

Winzor DJ.
PMID: 28510155
Biophys Rev. 2013 Jun;5(2):173-185. doi: 10.1007/s12551-013-0103-5. Epub 2013 Feb 14.

Difficulties are encountered in the thermodynamic characterization of interactions between a protein ligand and a linear acceptor, such as a polynucleotide or a polysaccharide, because of the involvement of more than one unit of the polymer chain in each...

Major determinants for the selecting antithrombotic therapies in patients with nonvalvular atrial fibrillation in Japan (JAPAF study).

Journal of arrhythmia

Kusakawa K, Harada KH, Kagimura T, Koizumi A.
PMID: 28416974
J Arrhythm. 2017 Apr;33(2):99-106. doi: 10.1016/j.joa.2016.06.006. Epub 2016 Aug 11.

BACKGROUND: Oral anticoagulants (OACs) can help prevent stroke in patients with nonvalvular atrial fibrillation (NVAF). The aim of this study was to characterize the use of OACs other than direct thrombin inhibitors (DTIs) for NVAF.METHODS: Patients with NVAF taking...

Reversing factor Xa inhibitors - clinical utility of andexanet alfa.

Journal of blood medicine

Kaatz S, Bhansali H, Gibbs J, Lavender R, Mahan CE, Paje DG.
PMID: 28979172
J Blood Med. 2017 Sep 13;8:141-149. doi: 10.2147/JBM.S121550. eCollection 2017.

Approximately half of patients started on an oral anticoagulant in the USA now receive one of the newer direct oral anticoagulants (DOACs). Although there is an approved reversal agent for the direct thrombin inhibitor dabigatran, a specific reversal agent...

Antithrombotic Management of Patients with Nonvalvular Atrial Fibrillation and Ischemic Stroke or Transient Ischemic Attack: Executive Summary of the Korean Clinical Practice Guidelines for Stroke.

Journal of stroke

Jung KH, Yu KH, Kim YD, Park JM, Hong KS, Rha JH, Kwon SU, Bae HJ, Heo JH, Lee BC, Yoon BW.
PMID: 26060808
J Stroke. 2015 May;17(2):210-5. doi: 10.5853/jos.2015.17.2.210. Epub 2015 May 29.

Cardioembolic stroke related to nonvalvular atrial fibrillation is associated with a high recurrence rate and high mortality and morbidity. In this population, therefore, optimal anticoagulant therapy is required to prevent the occurrence of second stroke. Oral anticoagulant, warfarin has...

Prognostic significance of antithrombin activity in patients with crimean-congo hemorrhagic Fever.

The Eurasian journal of medicine

Ozkurt Z, Ozden K, Kiki I, Usanmaz M.
PMID: 25610169
Eurasian J Med. 2011 Aug;43(2):83-6. doi: 10.5152/eajm.2011.19.

OBJECTIVE: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever. Disseminated intravascular coagulation (DIC) is an important complication of this disease, especially in severe and fatal cases. Antithrombin (AT) acts as an anticoagulant by inactivating thrombin, Factor IX,...

Global assays and the management of oral anticoagulation.

Thrombosis journal

Brinkman HJ.
PMID: 25762867
Thromb J. 2015 Feb 10;13:9. doi: 10.1186/s12959-015-0037-1. eCollection 2015.

Coagulation tests range from global or overall tests to assays specific to individual clotting factors and their inhibitors. Whether a particular test is influenced by an oral anticoagulant depends on the principle of the test and the type of...

Research in pharmaceutical sciences

Sajjadi SM, Rahimi H, Mohammadi S, Faranoush M, Mirzahoseini H, Toogeh G.
PMID: 28255315
Res Pharm Sci. 2017 Feb;12(1):60-66. doi: 10.4103/1735-5362.199048.

Hirudin is an anticoagulant agent of the salivary glands of the medicinal leech. Recombinant hirudin (r-Hir) displays certain drawbacks including bleeding and immunogenicity. To solve these problems, cysteine-specific PEGylation has been proposed as a successful technique. However, proper selection...

Showing 1 to 12 of 2875 entries