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Showing 1 to 12 of 25 entries
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Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models.

Assay and drug development technologies

Zhu XY, Xia B, Liu HC, Xu YQ, Huang CJ, Gao JM, Dong QX, Li CQ.
PMID: 27045536
Assay Drug Dev Technol. 2016 Jul;14(5):282-290. doi: 10.1089/adt.2015.679. Epub 2016 Apr 05.

Angiogenesis has emerged as an important therapeutic target in several major diseases, including cancer and age-related macular degeneration. The zebrafish offer the potential for high-throughput drug discovery in a whole vertebrate system. In this study, we have taken advantage...

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Zhu XY, Xia B, Liu HC, et al. Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models. Assay Drug Dev Technol. 2016;14(5):282-290doi: 10.1089/adt.2015.679.
Zhu, X. Y., Xia, B., Liu, H. C., Xu, Y. Q., Huang, C. J., Gao, J. M., Dong, Q. X., & Li, C. Q. (2016). Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models. Assay and drug development technologies, 14(5), 282-290. https://doi.org/10.1089/adt.2015.679
Zhu, Xiao-Yu, et al. "Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models." Assay and drug development technologies vol. 14,5 (2016): 282-290. doi: https://doi.org/10.1089/adt.2015.679
Zhu XY, Xia B, Liu HC, Xu YQ, Huang CJ, Gao JM, Dong QX, Li CQ. Closantel Suppresses Angiogenesis and Cancer Growth in Zebrafish Models. Assay Drug Dev Technol. 2016 Jul;14(5):282-290. doi: 10.1089/adt.2015.679. Epub 2016 Apr 05. PMID: 27045536.
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Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping.

ACS infectious diseases

Gooyit M, Harris TL, Tricoche N, Javor S, Lustigman S, Janda KD.
PMID: 27622649
ACS Infect Dis. 2015 May 08;1(5):198-202. doi: 10.1021/acsinfecdis.5b00017. Epub 2015 Mar 18.

The anthelmintic closantel has shown promise in abrogating the L3 molting of Onchocerca volvulus, the causative agent of the infectious disease onchocerciasis. In our search for alternative scaffolds, we utilized a fragment replacement/modification approach to generate novel chemotypes with...

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Gooyit M, Harris TL, Tricoche N, et al. Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping. ACS Infect Dis. 2015;1(5):198-202doi: 10.1021/acsinfecdis.5b00017.
Gooyit, M., Harris, T. L., Tricoche, N., Javor, S., Lustigman, S., & Janda, K. D. (2015). Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping. ACS infectious diseases, 1(5), 198-202. https://doi.org/10.1021/acsinfecdis.5b00017
Gooyit, Major, et al. "Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping." ACS infectious diseases vol. 1,5 (2015): 198-202. doi: https://doi.org/10.1021/acsinfecdis.5b00017
Gooyit M, Harris TL, Tricoche N, Javor S, Lustigman S, Janda KD. Onchocerca volvulus Molting Inhibitors Identified through Scaffold Hopping. ACS Infect Dis. 2015 May 08;1(5):198-202. doi: 10.1021/acsinfecdis.5b00017. Epub 2015 Mar 18. PMID: 27622649.
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Efficacy of closantel, fenbendazole and ivermectin against GI helminths of cattle in central Kashmir.

Journal of parasitic diseases : official organ of the Indian Society for Parasitology

Bushra M, Shahardar RA, Allaie IM, Wani ZA.
PMID: 31263335
J Parasit Dis. 2019 Jun;43(2):289-293. doi: 10.1007/s12639-019-01091-w. Epub 2019 Feb 11.

Three trials were conducted to evaluate the therapeutic efficacy of closantel (@ 7.5 mg/kg body weight, orally), fenbendazole (@ 7.5 mg/kg body weight, orally) and ivermectin bolus (@ 0.2 mg/kg body weight, orally) against gastrointestinal (GI) helminth parasites of...

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Bushra M, Shahardar RA, Allaie IM, et al. Efficacy of closantel, fenbendazole and ivermectin against GI helminths of cattle in central Kashmir. J Parasit Dis. 2019;43(2):289-293doi: 10.1007/s12639-019-01091-w.
Bushra, M., Shahardar, R. A., Allaie, I. M., & Wani, Z. A. (2019). Efficacy of closantel, fenbendazole and ivermectin against GI helminths of cattle in central Kashmir. Journal of parasitic diseases : official organ of the Indian Society for Parasitology, 43(2), 289-293. https://doi.org/10.1007/s12639-019-01091-w
Bushra, M, et al. "Efficacy of closantel, fenbendazole and ivermectin against GI helminths of cattle in central Kashmir." Journal of parasitic diseases : official organ of the Indian Society for Parasitology vol. 43,2 (2019): 289-293. doi: https://doi.org/10.1007/s12639-019-01091-w
Bushra M, Shahardar RA, Allaie IM, Wani ZA. Efficacy of closantel, fenbendazole and ivermectin against GI helminths of cattle in central Kashmir. J Parasit Dis. 2019 Jun;43(2):289-293. doi: 10.1007/s12639-019-01091-w. Epub 2019 Feb 11. PMID: 31263335; PMCID: PMC6570718.
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Tapeworm control practices by sheep farmers in Northern Ireland.

Veterinary parasitology, regional studies and reports

McMahon C, Edgar HWJ, Barley JP, Hanna REB, Brennan GP, Fairweather I.
PMID: 31014650
Vet Parasitol Reg Stud Reports. 2017 Jan;7:14-18. doi: 10.1016/j.vprsr.2016.12.003. Epub 2016 Dec 07.

A questionnaire to obtain information on tapeworm control practices was sent to 252 sheep farmers in Northern Ireland (NI) in 2012. Replies were received from 228 flock owners. Most farmers considered that tapeworm infections had less impact on productivity...

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McMahon C, Edgar HWJ, Barley JP, et al. Tapeworm control practices by sheep farmers in Northern Ireland. Vet Parasitol Reg Stud Reports. 2016;7:14-18doi: 10.1016/j.vprsr.2016.12.003.
McMahon, C., Edgar, H. W. J., Barley, J. P., Hanna, R. E. B., Brennan, G. P., & Fairweather, I. (2017). Tapeworm control practices by sheep farmers in Northern Ireland. Veterinary parasitology, regional studies and reports, 714-18. https://doi.org/10.1016/j.vprsr.2016.12.003
McMahon, C, et al. "Tapeworm control practices by sheep farmers in Northern Ireland." Veterinary parasitology, regional studies and reports vol. 7 (2017): 14-18. doi: https://doi.org/10.1016/j.vprsr.2016.12.003
McMahon C, Edgar HWJ, Barley JP, Hanna REB, Brennan GP, Fairweather I. Tapeworm control practices by sheep farmers in Northern Ireland. Vet Parasitol Reg Stud Reports. 2017 Jan;7:14-18. doi: 10.1016/j.vprsr.2016.12.003. Epub 2016 Dec 07. PMID: 31014650.
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Ophthalmic findings in sheep treated with closantel in Curitiba, Brazil.

Veterinary world

Bacellar-Galdino M, Montiani-Ferreira F, Somma AT, Vilani RGDC, Filho IRB.
PMID: 32636579
Vet World. 2020 May;13(5):860-864. doi: 10.14202/vetworld.2020.860-864. Epub 2020 May 08.

BACKGROUND AND AIM: Closantel is a widely used anti-parasitic drug that is known to cause ophthalmic problems that lead to blindness. The aim of this study was to investigate the possible electroretinographic changes in sheep that received closantel.MATERIALS AND...

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Bacellar-Galdino M, Montiani-Ferreira F, Somma AT, et al. Ophthalmic findings in sheep treated with closantel in Curitiba, Brazil. Vet World. 2020;13(5):860-864doi: 10.14202/vetworld.2020.860-864.
Bacellar-Galdino, M., Montiani-Ferreira, F., Somma, A. T., Vilani, R. G. D. C., & Filho, I. R. B. (2020). Ophthalmic findings in sheep treated with closantel in Curitiba, Brazil. Veterinary world, 13(5), 860-864. https://doi.org/10.14202/vetworld.2020.860-864
Bacellar-Galdino, Marianna, et al. "Ophthalmic findings in sheep treated with closantel in Curitiba, Brazil." Veterinary world vol. 13,5 (2020): 860-864. doi: https://doi.org/10.14202/vetworld.2020.860-864
Bacellar-Galdino M, Montiani-Ferreira F, Somma AT, Vilani RGDC, Filho IRB. Ophthalmic findings in sheep treated with closantel in Curitiba, Brazil. Vet World. 2020 May;13(5):860-864. doi: 10.14202/vetworld.2020.860-864. Epub 2020 May 08. PMID: 32636579; PMCID: PMC7311881.
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A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity.

Reactive oxygen species (Apex, N.C.)

Adeosun SO, Moore KH, Lang DM, Nwaneri AC, Hinds TD, Stec DE.
PMID: 29379885
React Oxyg Species (Apex). 2018;5(13):35-45. doi: 10.20455/ros.2018.809. Epub 2018 Jan 01.

Biliverdin reductase (BVR) is the enzyme responsible for the last step in the production of bilirubin from the breakdown of heme. Bilirubin is one of the most potent antioxidant molecules in the body. Monitoring BVR activity is essential in...

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Adeosun SO, Moore KH, Lang DM, et al. A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity. React Oxyg Species (Apex). 2018;5(13):35-45doi: 10.20455/ros.2018.809.
Adeosun, S. O., Moore, K. H., Lang, D. M., Nwaneri, A. C., Hinds, T. D., & Stec, D. E. (2018). A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity. Reactive oxygen species (Apex, N.C.), 5(13), 35-45. https://doi.org/10.20455/ros.2018.809
Adeosun, Samuel O, et al. "A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity." Reactive oxygen species (Apex, N.C.) vol. 5,13 (2018): 35-45. doi: https://doi.org/10.20455/ros.2018.809
Adeosun SO, Moore KH, Lang DM, Nwaneri AC, Hinds TD, Stec DE. A Novel Fluorescence-Based Assay for the Measurement of Biliverdin Reductase Activity. React Oxyg Species (Apex). 2018;5(13):35-45. doi: 10.20455/ros.2018.809. Epub 2018 Jan 01. PMID: 29379885; PMCID: PMC5785779.
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Developmental changes in energy metabolism ofSchistosoma mansoni and physiological role of oxygen in maintaining parasite function.

Journal of chemical ecology

Thompson DP, Bennett JL.
PMID: 24305902
J Chem Ecol. 1986 Aug;12(8):1885-900. doi: 10.1007/BF01022390.

The time course of the conversion from a cyanide-sensitive to a cyanide-insensitive energy metabolism in immatureSchistosoma mansoni was followed by correlating transitions in CO2 and lactate formation with physiological properties of the parasite. Volume conducted electrical potentials and measurement...

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Thompson DP, Bennett JL. Developmental changes in energy metabolism ofSchistosoma mansoni and physiological role of oxygen in maintaining parasite function. J Chem Ecol. 1986;12(8):1885-900doi: 10.1007/BF01022390.
Thompson, D. P., & Bennett, J. L. (1986). Developmental changes in energy metabolism ofSchistosoma mansoni and physiological role of oxygen in maintaining parasite function. Journal of chemical ecology, 12(8), 1885-900. https://doi.org/10.1007/BF01022390
Thompson, D P, and Bennett, J L. "Developmental changes in energy metabolism ofSchistosoma mansoni and physiological role of oxygen in maintaining parasite function." Journal of chemical ecology vol. 12,8 (1986): 1885-900. doi: https://doi.org/10.1007/BF01022390
Thompson DP, Bennett JL. Developmental changes in energy metabolism ofSchistosoma mansoni and physiological role of oxygen in maintaining parasite function. J Chem Ecol. 1986 Aug;12(8):1885-900. doi: 10.1007/BF01022390. PMID: 24305902.
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Closantel is an allosteric inhibitor of human Taspase1.

iScience

Luciano V, Proschak E, Langer JD, Knapp S, Heering J, Marschalek R.
PMID: 34934933
iScience. 2021 Nov 27;24(12):103524. doi: 10.1016/j.isci.2021.103524. eCollection 2021 Dec 17.

Dimerization of Taspase1 activates an intrinsic serine protease function that leads to the catalytic Thr234 residue, which allows to catalyze the consensus sequence Q

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Luciano V, Proschak E, Langer JD, et al. Closantel is an allosteric inhibitor of human Taspase1. iScience. 2021;24(12):103524doi: 10.1016/j.isci.2021.103524.
Luciano, V., Proschak, E., Langer, J. D., Knapp, S., Heering, J., & Marschalek, R. (2021). Closantel is an allosteric inhibitor of human Taspase1. iScience, 24(12), 103524. https://doi.org/10.1016/j.isci.2021.103524
Luciano, Vanessa, et al. "Closantel is an allosteric inhibitor of human Taspase1." iScience vol. 24,12 (2021): 103524. doi: https://doi.org/10.1016/j.isci.2021.103524
Luciano V, Proschak E, Langer JD, Knapp S, Heering J, Marschalek R. Closantel is an allosteric inhibitor of human Taspase1. iScience. 2021 Nov 27;24(12):103524. doi: 10.1016/j.isci.2021.103524. eCollection 2021 Dec 17. PMID: 34934933; PMCID: PMC8661544.
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Analytical Separation of Closantel Enantiomers by HPLC.

Molecules (Basel, Switzerland)

Saleh B, Ding T, Wang Y, Zheng X, Liu R, He L.
PMID: 34885866
Molecules. 2021 Nov 30;26(23). doi: 10.3390/molecules26237288.

Closantel is an antiparasitic drug marketed in a racemic form with one chiral center. It is meaningful to develop a method for separating and analyzing the closantel enantiomers. In this work, two enantiomeric separation methods of closantel were explored...

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Saleh B, Ding T, Wang Y, et al. Analytical Separation of Closantel Enantiomers by HPLC. Molecules. 2021;26(23)doi: 10.3390/molecules26237288.
Saleh, B., Ding, T., Wang, Y., Zheng, X., Liu, R., & He, L. (2021). Analytical Separation of Closantel Enantiomers by HPLC. Molecules (Basel, Switzerland), 26(23), . https://doi.org/10.3390/molecules26237288
Saleh, Basma, et al. "Analytical Separation of Closantel Enantiomers by HPLC." Molecules (Basel, Switzerland) vol. 26,23 (2021). doi: https://doi.org/10.3390/molecules26237288
Saleh B, Ding T, Wang Y, Zheng X, Liu R, He L. Analytical Separation of Closantel Enantiomers by HPLC. Molecules. 2021 Nov 30;26(23). doi: 10.3390/molecules26237288. PMID: 34885866; PMCID: PMC8659055.
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Reversible blindness after erroneous prescription of closantel: A case report.

Clinical case reports

Cheraghmakani H, Jafari R, Karimpour-Razkenari E, Ghazaeian M.
PMID: 34938546
Clin Case Rep. 2021 Dec 09;9(12):e05157. doi: 10.1002/ccr3.5157. eCollection 2021 Dec.

A 20-year-old girl was referred with vision loss upon closantel use. Plasma exchange and high-dose corticosteroid pulse therapy were administered. A 2.5-year follow-up showed improved vision and increased layer thickness of the peripheral nerve fiber. Early treatment with plasma...

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Cheraghmakani H, Jafari R, Karimpour-Razkenari E, et al. Reversible blindness after erroneous prescription of closantel: A case report. Clin Case Rep. 2021;9(12):e05157doi: 10.1002/ccr3.5157.
Cheraghmakani, H., Jafari, R., Karimpour-Razkenari, E., & Ghazaeian, M. (2021). Reversible blindness after erroneous prescription of closantel: A case report. Clinical case reports, 9(12), e05157. https://doi.org/10.1002/ccr3.5157
Cheraghmakani, Hamed, et al. "Reversible blindness after erroneous prescription of closantel: A case report." Clinical case reports vol. 9,12 (2021): e05157. doi: https://doi.org/10.1002/ccr3.5157
Cheraghmakani H, Jafari R, Karimpour-Razkenari E, Ghazaeian M. Reversible blindness after erroneous prescription of closantel: A case report. Clin Case Rep. 2021 Dec 09;9(12):e05157. doi: 10.1002/ccr3.5157. eCollection 2021 Dec. PMID: 34938546; PMCID: PMC8659543.
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Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents.

ChemMedChem

Fujii S, Kikuchi E, Suzuyama H, Watanabe Y, Ishigami-Yuasa M, Masuno H, Mori T, Isobe K, Uchida S, Kagechika H.
PMID: 34109743
ChemMedChem. 2021 Sep 16;16(18):2817-2822. doi: 10.1002/cmdc.202100273. Epub 2021 Jul 02.

Hypertension is an important target for drug discovery. We have focused on the with-no-lysine kinase (WNK)-oxidative stress-responsive 1 (OSR1) and STE20/SPS1-related proline-alanine-rich protein kinase (SPAK)-NaCl cotransporter (NCC) signal cascade as a potential target, and we previously developed a screening...

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Fujii S, Kikuchi E, Suzuyama H, et al. Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents. ChemMedChem. 2021;16(18):2817-2822doi: 10.1002/cmdc.202100273.
Fujii, S., Kikuchi, E., Suzuyama, H., Watanabe, Y., Ishigami-Yuasa, M., Masuno, H., Mori, T., Isobe, K., Uchida, S., & Kagechika, H. (2021). Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents. ChemMedChem, 16(18), 2817-2822. https://doi.org/10.1002/cmdc.202100273
Fujii, Shinya, et al. "Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents." ChemMedChem vol. 16,18 (2021): 2817-2822. doi: https://doi.org/10.1002/cmdc.202100273
Fujii S, Kikuchi E, Suzuyama H, Watanabe Y, Ishigami-Yuasa M, Masuno H, Mori T, Isobe K, Uchida S, Kagechika H. Structural Development of Salicylanilide-Based SPAK Inhibitors as Candidate Antihypertensive Agents. ChemMedChem. 2021 Sep 16;16(18):2817-2822. doi: 10.1002/cmdc.202100273. Epub 2021 Jul 02. PMID: 34109743.
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Multiple anthelmintic resistance in gastrointestinal nematodes of Caprines on Mountain Research Centre for Sheep and Goat at Kashmir Valley, India.

Parasite epidemiology and control

Bihaqi SJ, Allaie IM, Banday MAA, Sankar M, Wani ZA, Prasad A.
PMID: 32984565
Parasite Epidemiol Control. 2020 Jun 29;11:e00163. doi: 10.1016/j.parepi.2020.e00163. eCollection 2020 Nov.

The study was conducted to evaluate the status of anthelmintic resistance in Gastro-Intestinal Nematodes (GINs) of goats at an organized farm located in Kashmir, as there is no report of resistance against these parasites of goats from this temperate...

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Bihaqi SJ, Allaie IM, Banday MAA, et al. Multiple anthelmintic resistance in gastrointestinal nematodes of Caprines on Mountain Research Centre for Sheep and Goat at Kashmir Valley, India. Parasite Epidemiol Control. 2020;11:e00163doi: 10.1016/j.parepi.2020.e00163.
Bihaqi, S. J., Allaie, I. M., Banday, M. A. A., Sankar, M., Wani, Z. A., & Prasad, A. (2020). Multiple anthelmintic resistance in gastrointestinal nematodes of Caprines on Mountain Research Centre for Sheep and Goat at Kashmir Valley, India. Parasite epidemiology and control, 11e00163. https://doi.org/10.1016/j.parepi.2020.e00163
Bihaqi, S J, et al. "Multiple anthelmintic resistance in gastrointestinal nematodes of Caprines on Mountain Research Centre for Sheep and Goat at Kashmir Valley, India." Parasite epidemiology and control vol. 11 (2020): e00163. doi: https://doi.org/10.1016/j.parepi.2020.e00163
Bihaqi SJ, Allaie IM, Banday MAA, Sankar M, Wani ZA, Prasad A. Multiple anthelmintic resistance in gastrointestinal nematodes of Caprines on Mountain Research Centre for Sheep and Goat at Kashmir Valley, India. Parasite Epidemiol Control. 2020 Jun 29;11:e00163. doi: 10.1016/j.parepi.2020.e00163. eCollection 2020 Nov. PMID: 32984565; PMCID: PMC7494505.
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Showing 1 to 12 of 25 entries