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The PurR regulon in Escherichia coli K-12 MG1655

k-12

Cho BK, Embree M.
GSID: 77FsoKXzrk8J
BK Cho, SA Federowicz, M Embree… - Nucleic acids …, 2011 - academic.oup.com

The PurR transcription factor plays a critical role in transcriptional regulation of purine metabolism in enterobacteria. Here, we elucidate the role of PurR under exogenous adenine stimulation at the genome-scale using high-resolution chromatin immunoprecipitation (ChIP)–…

Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics …

discipline specific-education (e.g., chemistry education, biology education, economics education)

[No authors listed]
GSID: r81mkFsAmU8J
M Donnette, C Solas, M Giocanti, G Venton… - … of Chromatography B, 2019 - Elsevier

Purine analogs like aracytine (Arasingle bondC) are a mainstay for treating acute myeloid leukemia (AML). There are marked differences in drug dosing and scheduling depending on …

A modified intraoral resin mouthguard to prevent self-mutilations in lesch-nyhan patients.

International journal of dentistry

Ragazzini G, Delucchi A, Calcagno E, Servetto R, Denotti G.
PMID: 25101126
Int J Dent. 2014;2014:396830. doi: 10.1155/2014/396830. Epub 2014 Jul 02.

Lesch-Nyhan syndrome, described in 1964 by Lesch and Nyhan, is a X-linked recessive disorder, occurring in 1 : 100000 to 1 : 380000 live births. LNS is characterized by a decrease in activity of hypoxanthine guanine phosphoribosyl transferase, an...

Biological and Medicinal Significance of Purines.

Mini reviews in medicinal chemistry

Chaskar P, Chaudhari S, Dighe S, More N.
PMID: 22931527
Mini Rev Med Chem. 2012 Aug 27; Epub 2012 Aug 27.

This article outlines the biological significance of one of the most important heterocycles, the purines. An attempt has been made to cover most of the physiologically as well as medicinally important compounds containing the purine derivatives. Purines are the...

Role of Rb during Neurogenesis and Axonal Guidance in the Developing Olfactory System.

Frontiers in molecular neuroscience

Jaafar C, Omais S, Al Lafi S, El Jamal N, Noubani M, Skaf L, Ghanem N.
PMID: 27667971
Front Mol Neurosci. 2016 Sep 09;9:81. doi: 10.3389/fnmol.2016.00081. eCollection 2016.

The Retinoblastoma protein, Rb, was shown to regulate distinct aspects of neurogenesis in the embryonic and adult brain besides its primary role in cell cycle control. It is still unknown, however, whether Rb is required for tissue morphogenesis and...

Leukocyte Expression of Type 1 and Type 2 Purinergic Receptors and Pro-Inflammatory Cytokines during Total Sleep Deprivation and/or Sleep Extension in Healthy Subjects.

Frontiers in neuroscience

Chennaoui M, Arnal PJ, Drogou C, Leger D, Sauvet F, Gomez-Merino D.
PMID: 28512397
Front Neurosci. 2017 May 02;11:240. doi: 10.3389/fnins.2017.00240. eCollection 2017.

The purinergic type P1 (adenosine A

Profile of obinutuzumab for the treatment of patients with previously untreated chronic lymphocytic leukemia.

OncoTargets and therapy

Hill BT, Kalaycio M.
PMID: 26366093
Onco Targets Ther. 2015 Aug 31;8:2391-7. doi: 10.2147/OTT.S68770. eCollection 2015.

Chronic lymphocytic leukemia (CLL) is a hematologic malignancy derived from a clonal population of mature B-lymphocytes characterized by relatively low CD20 antigen expression. Although the disease often takes an indolent course, the majority of patients will eventually require therapy....

RASopathies: unraveling mechanisms with animal models.

Disease models & mechanisms

Jindal GA, Goyal Y, Burdine RD, Rauen KA, Shvartsman SY.
PMID: 26398161
Dis Model Mech. 2015 Sep;8(9):1167. doi: 10.1242/dmm.022442.

No abstract available.

Crystal structures of five 6-mercaptopurine derivatives.

Acta crystallographica. Section E, Crystallographic communications

Gomes LR, Low JN, Magalhães E Silva D, Cagide F, Borges F.
PMID: 27006794
Acta Crystallogr E Crystallogr Commun. 2016 Feb 10;72:307-13. doi: 10.1107/S2056989016001833. eCollection 2016 Mar 01.

The crystal structures of five 6-mercaptopurine derivatives, viz. 2-[(9-acetyl-9H-purin-6-yl)sulfan-yl]-1-(3-meth-oxy-phen-yl)ethan-1-one (1), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfan-yl]-1-(4-meth-oxy-phen-yl)ethan-1-one (2), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfan-yl]-1-(4-chloro-phen-yl)ethan-1-one (3), C15H11ClN4O2S, 2-[(9-acetyl-9H-purin-6-yl)sulfan-yl]-1-(4-bromo-phen-yl)ethan-1-one (4), C15H11BrN4O2S, and 1-(3-meth-oxy-phen-yl)-2-[(9H-purin-6-yl)sulfan-yl]ethan-1-one (5), C14H12N4O2S. Compounds (2), (3) and (4) are isomorphous and accordingly their mol-ecular and supra-molecular structures are...

Electronic Structures of Mono-Oxidized Copper and Nickel Phosphasalen Complexes.

Chemistry (Weinheim an der Bergstrasse, Germany)

Mustieles Marín I, Cheisson T, Singh-Chauhan R, Herrero C, Cordier M, Clavaguéra C, Nocton G, Auffrant A.
PMID: 28980736
Chemistry. 2017 Dec 19;23(71):17940-17953. doi: 10.1002/chem.201703390. Epub 2017 Nov 22.

Non-innocent ligands render the determination of the electronic structure in metal complexes difficult. As such, a combination of experimental techniques and quantum chemistry are required to correctly elucidate them. This paper deals with the one-electron oxidation of copper(II) and...

Epigenetic control of HIV-1 post integration latency: implications for therapy.

Clinical epigenetics

Kumar A, Darcis G, Van Lint C, Herbein G.
PMID: 26405463
Clin Epigenetics. 2015 Sep 24;7:103. doi: 10.1186/s13148-015-0137-6. eCollection 2015.

With the development of effective combined anti-retroviral therapy (cART), there is significant reduction in deaths associated with human immunodeficiency virus type 1 (HIV-1) infection. However, the complete cure of HIV-1 infection is difficult to achieve without the elimination of...

Colonization and Succession within the Human Gut Microbiome by Archaea, Bacteria, and Microeukaryotes during the First Year of Life.

Frontiers in microbiology

Wampach L, Heintz-Buschart A, Hogan A, Muller EEL, Narayanasamy S, Laczny CC, Hugerth LW, Bindl L, Bottu J, Andersson AF, de Beaufort C, Wilmes P.
PMID: 28512451
Front Microbiol. 2017 May 02;8:738. doi: 10.3389/fmicb.2017.00738. eCollection 2017.

Perturbations to the colonization process of the human gastrointestinal tract have been suggested to result in adverse health effects later in life. Although much research has been performed on bacterial colonization and succession, much less is known about the...

Showing 1 to 12 of 5010 entries