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Showing 1 to 12 of 52 entries
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Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayés M, Rabasseda X, Prous JR.
PMID: 12616965
Methods Find Exp Clin Pharmacol. 2002 Dec;24(10):703-29.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Studies knowledge area of Prous Science Integrity, the drug...

Oral valdecoxib and injected parecoxib for acute postoperative pain: a quantitative systematic review.

BMC anesthesiology

Barden J, Edwards JE, McQuay HJ, Moore RA.
PMID: 12854974
BMC Anesthesiol. 2003 Jul 10;3(1):1. doi: 10.1186/1471-2253-3-1.

BACKGROUND: Clinical trials suggest that cyclo-oxygenase-2 specific inhibitors (coxibs) are an effective treatment for acute postoperative pain. The aims of this systematic review were to examine the evidence for oral valdecoxib and injected parecoxib, and quantify efficacy and adverse...

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayés M, Rabasseda X, Prous JR.
PMID: 15148527
Methods Find Exp Clin Pharmacol. 2004 Apr;26(3):211-44.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Studies Knowledge Area of Prous Science Integrity(R), the drug...

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayés M, Rabasseda X, Prous JR.
PMID: 16082422
Methods Find Exp Clin Pharmacol. 2005 Jun;27(5):331-72.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug...

Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data.

Pediatric rheumatology online journal

Levy DM, Imundo LF.
PMID: 20181090
Pediatr Rheumatol Online J. 2010 Feb 04;8:7. doi: 10.1186/1546-0096-8-7.

OBJECTIVES: To examine the prescribing habits of NSAIDs among pediatric medical and surgical practitioners, and to examine concerns and barriers to their use.METHODS: A sample of 1289 pediatricians, pediatric rheumatologists, sports medicine physicians, pediatric surgeons and pediatric orthopedic surgeons...

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayes M, Rabasseda X, Prous JR.
PMID: 16082427
Methods Find Exp Clin Pharmacol. 2005 May;27(4):265-84.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug...

Validation of single isocratic HPLC method for the assay of valdecoxib and determination of metaisomer impurity.

Journal of chromatographic science

Karthikeyan K, Saravanan R, Rajeswari R, Chandrasekara Pillai K.
PMID: 19406018
J Chromatogr Sci. 2009 Apr;47(4):309-14. doi: 10.1093/chromsci/47.4.309.

A sensitive and accurate isocratic high-performance liquid chromagraphic method is developed for the determination of both metaisomer impurity and assay of valdecoxib drug substance. This method uses a Phenomenex Luna C18 (2) column, a mobile phase of 60:30:10 (v/v)...

Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships.

Iranian journal of pharmaceutical research : IJPR

Zarghi A, Arfaei S.
PMID: 24250402
Iran J Pharm Res. 2011;10(4):655-83.

Non-steroidal anti-inflammatory drugs (NSAIDs) are the competitive inhibitors of cyclooxygenase (COX), the enzyme which mediates the bioconversion of arachidonic acid to inflammatory prostaglandins (PGs). Their use is associated with the side effects such as gastrointestinal and renal toxicity. The...

Role of selective cyclooxygenase-2 inhibitors in exacerbation of inflammatory bowel disease: A systematic review and meta-analysis.

Current therapeutic research, clinical and experimental

Miao XP, Ouyang Q, Li HY, Wen ZH, Zhang DK, Cui XY.
PMID: 24692797
Curr Ther Res Clin Exp. 2008 Jun;69(3):181-91. doi: 10.1016/j.curtheres.2008.06.009.

BACKGROUND: In the general population, selective cyclooxygenase (COX)-2 inhibitors have been associated with fewer gastrointestinal adverse effects (AEs) than NSAIDs, but whether they are associated with exacerbations in patients with inflammatory bowel disease (IBD) remains controversial.OBJECTIVE: The aim of...

Valdecoxib blocks rat TRPV2 channels.

European journal of pharmacology

Bluhm Y, Raudszus R, Wagner A, Urban N, Schaefer M, Hill K.
PMID: 34919887
Eur J Pharmacol. 2021 Dec 14;174702. doi: 10.1016/j.ejphar.2021.174702. Epub 2021 Dec 14.

The transient receptor potential vanilloid 2 (TRPV2) channel is broadly expressed in a multitude of different tissues and is implicated in the pathology of several diseases, such as the progression of different cancer types. However, a lack of specific,...

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayés M, Rabasseda X, Prous JR.
PMID: 12690708
Methods Find Exp Clin Pharmacol. 2003 Jan-Feb;25(1):53-76.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Studies knowledge area of Prous Science Integrity, the drug...

Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.

MedChemComm

Roscales S, Bechmann N, Weiss DH, Köckerling M, Pietzsch J, Kniess T.
PMID: 30108944
Medchemcomm. 2018 Feb 13;9(3):534-544. doi: 10.1039/c7md00575j. eCollection 2018 Mar 01.

Novel valdecoxib-based cyclooxygenase-2 inhibitors were synthesized in one step

Showing 1 to 12 of 52 entries