Display options
Cite
Williams JP, Lock R, Patel VJ, et al. Polarity switching accurate mass measurement of pharmaceutical samples using desorption electrospray ionization and a dual ion source interfaced to an orthogonal acceleration time-of-flight mass spectrometer. Anal Chem. 2006;78(21):7440-5doi: 10.1021/ac0609125.
Williams, J. P., Lock, R., Patel, V. J., & Scrivens, J. H. (2006). Polarity switching accurate mass measurement of pharmaceutical samples using desorption electrospray ionization and a dual ion source interfaced to an orthogonal acceleration time-of-flight mass spectrometer. Analytical chemistry, 78(21), 7440-5. https://doi.org/10.1021/ac0609125
Williams, Jonathan P, et al. "Polarity switching accurate mass measurement of pharmaceutical samples using desorption electrospray ionization and a dual ion source interfaced to an orthogonal acceleration time-of-flight mass spectrometer." Analytical chemistry vol. 78,21 (2006): 7440-5. doi: https://doi.org/10.1021/ac0609125
Williams JP, Lock R, Patel VJ, Scrivens JH. Polarity switching accurate mass measurement of pharmaceutical samples using desorption electrospray ionization and a dual ion source interfaced to an orthogonal acceleration time-of-flight mass spectrometer. Anal Chem. 2006 Nov 01;78(21):7440-5. doi: 10.1021/ac0609125. PMID: 17073410.
Copy Download .nbib Format: NLM
Share it on

Anal Chem. 2006 Nov 01;78(21):7440-5. doi: 10.1021/ac0609125.

Polarity switching accurate mass measurement of pharmaceutical samples using desorption electrospray ionization and a dual ion source interfaced to an orthogonal acceleration time-of-flight mass spectrometer.

Analytical chemistry

Jonathan P Williams, Richard Lock, Vibhuti J Patel, James H Scrivens

Affiliations

  1. Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. [email protected]

PMID: 17073410 DOI: 10.1021/ac0609125

Abstract

A novel approach for the rapid, accurate mass analysis of pharmaceutical solid, liquid, and cream formulations using desorption electrospray ionization (DESI) is described. The method is based on polarity switching and real-time accurate mass measurement in an orthogonal acceleration time-of-flight mass spectrometer fitted with a dual-inlet electrospray ion source. Infusion of a reference compound into one inlet provides a single-point "lock mass" for accurate mass measurement. The other inlet sprays solvent at the sample being investigated using DESI. Minimal sample preparation was required. Results demonstrate the ability to acquire simultaneously positive and negative accurate mass DESI data within the same acquisition, thus negating the need for repeat analysis in each ion mode. In this paper, drugs that preferentially ionize in a particular mode depending on their physiochemical properties are presented. Mass accuracy to within 2 mTh was obtained for all drugs sampled.

Substances

MeSH terms

Publication Types