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Algeciras-Schimnich A, Belzacq-Casagrande AS, Bren GD, et al. Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria. Open Virol J. 2007;1:39-46doi: 10.2174/1874357900701010039.
Algeciras-Schimnich, A., Belzacq-Casagrande, A. S., Bren, G. D., Nie, Z., Taylor, J. A., Rizza, S. A., Brenner, C., & Badley, A. D. (2007). Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria. The open virology journal, 139-46. https://doi.org/10.2174/1874357900701010039
Algeciras-Schimnich, Alicia, et al. "Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria." The open virology journal vol. 1 (2007): 39-46. doi: https://doi.org/10.2174/1874357900701010039
Algeciras-Schimnich A, Belzacq-Casagrande AS, Bren GD, Nie Z, Taylor JA, Rizza SA, Brenner C, Badley AD. Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria. Open Virol J. 2007 Dec 27;1:39-46. doi: 10.2174/1874357900701010039. PMID: 18818773; PMCID: PMC2548302.
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Open Virol J. 2007 Dec 27;1:39-46. doi: 10.2174/1874357900701010039.

Analysis of HIV Protease Killing Through Caspase 8 Reveals a Novel Interaction Between Caspase 8 and Mitochondria.

The open virology journal

Alicia Algeciras-Schimnich, Anne-Sophie Belzacq-Casagrande, Gary D Bren, Zilin Nie, Julie A Taylor, Stacey A Rizza, Catherine Brenner, Andrew D Badley

Affiliations

  1. Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA.

PMID: 18818773 PMCID: PMC2548302 DOI: 10.2174/1874357900701010039

Abstract

Human Immunodeficiency Virus (HIV) protease initiates apoptosis of HIV-infected cells by proteolytic cleavage of procaspase 8, creating a novel peptide termed casp8p41. Expression of casp8p41 alone is sufficient to initiate caspase-dependent cell death associated with mitochondrial depolarization. Since casp8p41 does not contain the catalytic cysteine at position 360, the mechanism by which casp8p41 initiates apoptosis is unclear. We demonstrate that casp8p41 directly causes mitochondrial depolarization and release of cytochrome c with downstream caspase 9 activation. Moreover, death induced by casp8p41 requires the presence of mitochondria, and in intact cells, casp8p41 colocalizes with mitochondria. These results illuminate a novel mechanism of cell death induced by a caspase 8 cleavage fragment whereby mitochondrial interaction leads to depolarization and cytochrome c release.

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