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Kohli U, Grayson BL, Aune TM, et al. Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response. Arch Drug Inf. 2009;2(3):41-50doi: 10.1111/j.1753-5174.2009.00020.x.
Kohli, U., Grayson, B. L., Aune, T. M., Ghimire, L. V., Kurnik, D., & Stein, C. M. (2009). Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response. Archives of drug information, 2(3), 41-50. https://doi.org/10.1111/j.1753-5174.2009.00020.x
Kohli, Utkarsh, et al. "Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response." Archives of drug information vol. 2,3 (2009): 41-50. doi: https://doi.org/10.1111/j.1753-5174.2009.00020.x
Kohli U, Grayson BL, Aune TM, Ghimire LV, Kurnik D, Stein CM. Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response. Arch Drug Inf. 2009 Sep;2(3):41-50. doi: 10.1111/j.1753-5174.2009.00020.x. PMID: 19915711; PMCID: PMC2773526.
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Arch Drug Inf. 2009 Sep;2(3):41-50. doi: 10.1111/j.1753-5174.2009.00020.x.

Change in mRNA Expression after Atenolol, a Beta-adrenergic Receptor Antagonist and Association with Pharmacological Response.

Archives of drug information

Utkarsh Kohli, Britney L Grayson, Thomas M Aune, Laxmi V Ghimire, Daniel Kurnik, C Michael Stein

PMID: 19915711 PMCID: PMC2773526 DOI: 10.1111/j.1753-5174.2009.00020.x

Abstract

AIMS: Genetic determinants of variability in response to beta-blockers are poorly characterized. We defined changes in mRNA expression after a beta-blocker to identify novel genes that could affect response and correlated these with inhibition of exercise-induced tachycardia, a measure of beta-blocker sensitivity. METHODS: Nine subjects exercised before and after a single oral dose of 25mg atenolol and mRNA gene expression was measured using an Affymetrix GeneChip Human Gene 1.0 ST Array. The area under the heart rate-exercise intensity curve (AUC) was calculated for each subject; the difference between post- and pre-atenolol AUCs (Delta AUC), a measure of beta-blocker response, was correlated with the fold-change in mRNA expression of the genes that changed more than 1.3-fold. RESULTS: Fifty genes showed more than 1.3-fold increase in expression; 9 of these reached statistical significance (P < 0.05). Thirty-six genes had more than 1.3-fold decrease in expression after atenolol; 6 of these reached statistical significance (P < 0.05). Change in mRNA expression of FGFBP2 and Probeset ID 8118979 was significantly correlated with atenolol response (P = 0.03 and 0.02, respectively). CONCLUSION: The expression of several genes not previously identified as part of the adrenergic signaling pathway changed in response to a single oral dose of atenolol. Variation in these genes could contribute to unexplained differences in response to beta-blockers.

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