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Day J, Schlesinger LS, Friedman A. Tuberculosis research: going forward with a powerful "translational systems biology" approach. Tuberculosis (Edinb). 2010;90(1):7-8doi: 10.1016/j.tube.2009.12.002.
Day, J., Schlesinger, L. S., & Friedman, A. (2010). Tuberculosis research: going forward with a powerful "translational systems biology" approach. Tuberculosis (Edinburgh, Scotland), 90(1), 7-8. https://doi.org/10.1016/j.tube.2009.12.002
Day, Judy, et al. "Tuberculosis research: going forward with a powerful "translational systems biology" approach." Tuberculosis (Edinburgh, Scotland) vol. 90,1 (2010): 7-8. doi: https://doi.org/10.1016/j.tube.2009.12.002
Day J, Schlesinger LS, Friedman A. Tuberculosis research: going forward with a powerful "translational systems biology" approach. Tuberculosis (Edinb). 2010 Jan;90(1):7-8. doi: 10.1016/j.tube.2009.12.002. Epub 2010 Jan 04. PMID: 20045665; PMCID: PMC2819545.
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Tuberculosis (Edinb). 2010 Jan;90(1):7-8. doi: 10.1016/j.tube.2009.12.002. Epub 2010 Jan 04.

Tuberculosis research: going forward with a powerful "translational systems biology" approach.

Tuberculosis (Edinburgh, Scotland)

Judy Day, Larry S Schlesinger, Avner Friedman

Affiliations

  1. Mathematical Biosciences Institute, The Ohio State University, Jennings Hall, 3rd Floor, 1735 Neil Ave, Columbus, OH 43210, USA. [email protected]

PMID: 20045665 PMCID: PMC2819545 DOI: 10.1016/j.tube.2009.12.002

Abstract

Due to the complexity of the immune response to a Mycobacterium tuberculosis infection, identifying new, effective therapies and vaccines to combat it has been a problematic issue. Although many advances have been made in understanding particular mechanisms involved, they have, to date, proved insufficient to provide real breakthroughs in this area of tuberculosis research. The term "Translational Systems Biology" has been formally proposed to describe the use of experimental findings combined with mathematical modeling and/or engineering principles to understand complex biological processes in an integrative fashion for the purpose of enhancing clinical practice. This opinion piece discusses the importance of using a Translational Systems Biology approach for tuberculosis research as a means by which to go forward with the potential for significant breakthroughs to occur.

References

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