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Zhang C, Li Y, Qian ZJ, et al. Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway. Evid Based Complement Alternat Med. 2011;2011:140462doi: 10.1155/2011/140462.
Zhang, C., Li, Y., Qian, Z. J., Lee, S. H., Li, Y. X., & Kim, S. K. (2011). Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway. Evidence-based complementary and alternative medicine : eCAM, 2011140462. https://doi.org/10.1155/2011/140462
Zhang, Chen, et al. "Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway." Evidence-based complementary and alternative medicine : eCAM vol. 2011 (2011): 140462. doi: https://doi.org/10.1155/2011/140462
Zhang C, Li Y, Qian ZJ, Lee SH, Li YX, Kim SK. Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway. Evid Based Complement Alternat Med. 2011;2011:140462. doi: 10.1155/2011/140462. Epub 2011 Aug 04. PMID: 21826183; PMCID: PMC3151525.
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Evid Based Complement Alternat Med. 2011;2011:140462. doi: 10.1155/2011/140462. Epub 2011 Aug 04.

Dieckol from Ecklonia cava Regulates Invasion of Human Fibrosarcoma Cells and Modulates MMP-2 and MMP-9 Expression via NF-κB Pathway.

Evidence-based complementary and alternative medicine : eCAM

Chen Zhang, Yong Li, Zhong-Ji Qian, Sang-Hoon Lee, Yong-Xin Li, Se-Kwon Kim

Affiliations

  1. Department of Chemistry, Pukyong National University, Busan 608-737, Republic of Korea.

PMID: 21826183 PMCID: PMC3151525 DOI: 10.1155/2011/140462

Abstract

The matrix metalloproteinase (MMP) family is involved in the breakdown of extracellular matrix in normal physiological processes, as well as in the disease processes such as arthritis and cancer metastasis. In the present study, dieckol was obtained with high yield from marine brown alga Ecklonia cava (EC), and its effect was assessed on the expression of MMP-2 and -9 and morphological changes in human fibrosarcoma cell line (HT1080). Dieckol inhibited the expression of MMP-2 and -9 in a dose-dependent manner and also suppressed the cell invasion and the cytomorphology in 3D culture system on HT1080 cells. Moreover, dieckol may influence nuclear factor kappa B (NF-κB) pathway without obvious influence on activator protein-1 (AP-1) pathway and tissue inhibitor of metalloproteinases (TIMPs). In conclusion, dieckol could significantly suppress MMP-2 and -9 expression and alter cytomorphology of HT1080 cell line via NF-κB pathway.

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