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Drug Discov Today Dis Models. 2010;7(3):123-130. doi: 10.1016/j.ddmod.2011.04.001. Epub 2011 May 06.

Tension Measurement in Isolated Rat and Mouse Pulmonary Artery.

Drug discovery today. Disease models

Eun A Ko, Michael Y Song, Reshma Donthamsetty, Ayako Makino, Jason X-J Yuan

Affiliations

  1. Departments of Medicine, University of Illinois at Chicago, Chicago, IL 60612.

PMID: 23175638 PMCID: PMC3501740 DOI: 10.1016/j.ddmod.2011.04.001

Abstract

Arterial vasoconstriction is an important physiological process in regulating blood pressure, and is involved in pathologies. The isolation of arteries from rats and mice, as well as the measurement of vascular tension in an ex vivo preparation, are important methods in studying the physiology of arteries and the pathophysiology associated with arterials. Three major methods to measure vascular tension are organ bath, wire myograph, and pressurized arterial myograph. The major method to measure vascular remodeling is by observing the zero-stress state of an artery.

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