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Bailey JN, Lu L, Chou JW, et al. The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease. J Mol Genet Med. 2013;7:61doi: 10.4172/1747-0862.1000061.
Bailey, J. N., Lu, L., Chou, J. W., Xu, J., McWilliams, D. R., Howard, T. D., Freedman, B. I., Bowden, D. W., Langefeld, C. D., & Palmer, N. D. (2013). The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease. Journal of molecular and genetic medicine : an international journal of biomedical research, 761. https://doi.org/10.4172/1747-0862.1000061
Bailey, Jessica N Cooke, et al. "The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease." Journal of molecular and genetic medicine : an international journal of biomedical research vol. 7 (2013): 61. doi: https://doi.org/10.4172/1747-0862.1000061
Bailey JN, Lu L, Chou JW, Xu J, McWilliams DR, Howard TD, Freedman BI, Bowden DW, Langefeld CD, Palmer ND. The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease. J Mol Genet Med. 2013 Jul 31;7:61. doi: 10.4172/1747-0862.1000061. PMID: 24707315; PMCID: PMC3973178.
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J Mol Genet Med. 2013 Jul 31;7:61. doi: 10.4172/1747-0862.1000061.

The Role of Copy Number Variation in African Americans with Type 2 Diabetes-Associated End Stage Renal Disease.

Journal of molecular and genetic medicine : an international journal of biomedical research

Jessica N Cooke Bailey, Lingyi Lu, Jeff W Chou, Jianzhao Xu, David R McWilliams, Timothy D Howard, Barry I Freedman, Donald W Bowden, Carl D Langefeld, Nicholette D Palmer

Affiliations

  1. Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA ; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA ; Center for Diabetes Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.
  2. Department of Biostatistical Sciences - Division of Public Health Sciences, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.
  3. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.
  4. Department of Internal Medicine - Section on Nephrology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.
  5. Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA ; Center for Diabetes Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA ; Department of Biochemistry, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA ; Department of Internal Medicine - Section on Endocrinology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.
  6. Program in Molecular Medicine and Translational Science, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA ; Center for Diabetes Research, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA ; Department of Biochemistry, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

PMID: 24707315 PMCID: PMC3973178 DOI: 10.4172/1747-0862.1000061

Abstract

This study investigated the association of copy number variants (CNVs) in type 2 diabetes (T2D) and T2D-associated end-stage renal disease (ESRD) in African Americans. Using the Affymetrix 6.0 array, >900,000 CNV probes spanning the genome were interrogated in 965 African Americans with T2D-ESRD and 1029 non-diabetic African American controls. Previously identified and novel CNVs were separately analyzed and were evaluated for insertion/deletion status and then used as predictors in a logistic regression model to test for association. One common CNV insertion on chromosome 1 was significantly associated with T2D-ESRD (p=6.17×10

Keywords: African Americans; Copy number variation; Diabetic nephropathy; End-stage renal disease; Genome-wide association study; Type 2 diabetes

References

  1. Cellscience. 2006 Apr 30;2(4):100-131 - PubMed
  2. Nat Genet. 2009 Jan;41(1):77-81 - PubMed
  3. Am J Hum Genet. 2010 Nov 12;87(5):661-6 - PubMed
  4. Hum Mol Genet. 2010 Jul 1;19(13):2725-38 - PubMed
  5. Nature. 2010 Feb 4;463(7281):671-5 - PubMed
  6. J Hum Genet. 2009 Apr;54(4):199-202 - PubMed
  7. PLoS One. 2011 Apr 22;6(4):e19091 - PubMed
  8. Nature. 2010 Apr 1;464(7289):713-20 - PubMed
  9. Nat Genet. 2008 Oct;40(10):1166-74 - PubMed
  10. Diabetes. 2010 Oct;59(10):2690-4 - PubMed
  11. Nat Genet. 2007 Oct;39(10):1256-60 - PubMed
  12. JAMA. 2011 Jun 22;305(24):2532-9 - PubMed
  13. Nat Genet. 2010 Feb;42(2):105-16 - PubMed
  14. BMC Genet. 2009 Mar 24;10:15 - PubMed
  15. Nature. 2006 Feb 16;439(7078):851-5 - PubMed
  16. Science. 2007 Feb 9;315(5813):848-53 - PubMed
  17. Kidney Int. 2011 Mar;79(5):563-72 - PubMed
  18. Trends Genet. 2008 Dec;24(12):613-21 - PubMed
  19. Genet Epidemiol. 2005 May;28(4):289-301 - PubMed
  20. Nat Genet. 2008 Oct;40(10):1253-60 - PubMed
  21. PLoS One. 2012;7(1):e29202 - PubMed
  22. BMC Genomics. 2010 Jul 12;11:426 - PubMed

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