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Vimaleswaran KS, Minihane AM, Li Y, et al. The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Nutr Metab (Lond). 2015;12:7doi: 10.1186/s12986-015-0002-9.
Vimaleswaran, K. S., Minihane, A. M., Li, Y., Gill, R., Lovegrove, J. A., Williams, C. M., & Jackson, K. G. (2015). The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Nutrition & metabolism, 127. https://doi.org/10.1186/s12986-015-0002-9
Vimaleswaran, Karani Santhanakrishnan, et al. "The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults." Nutrition & metabolism vol. 12 (2015): 7. doi: https://doi.org/10.1186/s12986-015-0002-9
Vimaleswaran KS, Minihane AM, Li Y, Gill R, Lovegrove JA, Williams CM, Jackson KG. The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults. Nutr Metab (Lond). 2015 Mar 08;12:7. doi: 10.1186/s12986-015-0002-9. eCollection 2015. PMID: 25793007; PMCID: PMC4365815.
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Nutr Metab (Lond). 2015 Mar 08;12:7. doi: 10.1186/s12986-015-0002-9. eCollection 2015.

The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults.

Nutrition & metabolism

Karani Santhanakrishnan Vimaleswaran, Anne M Minihane, Yue Li, Rosalyn Gill, Julie A Lovegrove, Christine M Williams, Kim G Jackson

Affiliations

  1. Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP UK ; Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading, UK.
  2. Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP UK ; Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, UK.
  3. Boston Heart Diagnostics, Framingham, MA 01702 USA.
  4. Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading, UK.

PMID: 25793007 PMCID: PMC4365815 DOI: 10.1186/s12986-015-0002-9

Abstract

BACKGROUND: Apolipoprotein (apo)B is the structural apoprotein of intestinally- and liver- derived lipoproteins and plays an important role in the transport of triacylglycerol (TAG) and cholesterol. Previous studies have examined the association between the APOB insertion/deletion (ins/del) polymorphism (rs17240441) and postprandial lipaemia in response to a single meal; however the findings have been inconsistent with studies often underpowered to detect genotype-lipaemia associations, focused mainly on men, or with limited postprandial characterisation of participants. In the present study, using a novel sequential test meal protocol which more closely mimics habitual eating patterns, we investigated the impact of APOB ins/del polymorphism on postprandial TAG, non-esterified fatty acids, glucose and insulin levels in healthy adults.

FINDINGS: Healthy participants (n = 147) consumed a standard test breakfast (0 min; 49 g fat) and lunch (330 min; 29 g fat), with blood samples collected before (fasting) and on 11 subsequent occasions until 480 min after the test breakfast. The ins/ins homozygotes had higher fasting total cholesterol, LDL-cholesterol, TAG, insulin and HOMA-IR and lower HDL-cholesterol than del/del homozygotes (P < 0.017). A higher area under the time response curve (AUC) was evident for the postprandial TAG (P < 0.001) and insulin (P = 0.032) responses in the ins/ins homozygotes relative to the del/del homozygotes, where the genotype explained 35% and 7% of the variation in the TAG and insulin AUCs, respectively.

CONCLUSIONS: In summary, our findings indicate that the APOB ins/del polymorphism is likely to be an important genetic determinant of the large inter-individual variability in the postprandial TAG and insulin responses to dietary fat intake.

Keywords: APOB gene; Insertion/deletion polymorphism; Postprandial study; Sequential test meals; Signal peptide polymorphism; Triacylglycerol

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