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Yimam M, Lee YC, Kim TW, et al. UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model. Evid Based Complement Alternat Med. 2015;2015:785638doi: 10.1155/2015/785638.
Yimam, M., Lee, Y. C., Kim, T. W., Moore, B., Jiao, P., Hong, M., Kim, H. J., Nam, J. B., Kim, M. R., Oh, J. S., Cleveland, S., Hyun, E. J., Chu, M., & Jia, Q. (2015). UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model. Evidence-based complementary and alternative medicine : eCAM, 2015785638. https://doi.org/10.1155/2015/785638
Yimam, Mesfin, et al. "UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model." Evidence-based complementary and alternative medicine : eCAM vol. 2015 (2015): 785638. doi: https://doi.org/10.1155/2015/785638
Yimam M, Lee YC, Kim TW, Moore B, Jiao P, Hong M, Kim HJ, Nam JB, Kim MR, Oh JS, Cleveland S, Hyun EJ, Chu M, Jia Q. UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model. Evid Based Complement Alternat Med. 2015;2015:785638. doi: 10.1155/2015/785638. Epub 2015 Feb 23. PMID: 25802546; PMCID: PMC4353658.
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Evid Based Complement Alternat Med. 2015;2015:785638. doi: 10.1155/2015/785638. Epub 2015 Feb 23.

UP3005, a Botanical Composition Containing Two Standardized Extracts of Uncaria gambir and Morus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model.

Evidence-based complementary and alternative medicine : eCAM

Mesfin Yimam, Young-Chul Lee, Tae-Woo Kim, Breanna Moore, Ping Jiao, Mei Hong, Hyun-Jin Kim, Jeong-Bum Nam, Mi-Ran Kim, Jin-Sun Oh, Sabrina Cleveland, Eu-Jin Hyun, Min Chu, Qi Jia

Affiliations

  1. Unigen, Inc., 3005 1st Avenue, Seattle, WA 98121, USA ; Unigen, Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of Korea.
  2. Unigen, Inc., No. 450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of Korea.
  3. Unigen, Inc., 3005 1st Avenue, Seattle, WA 98121, USA.

PMID: 25802546 PMCID: PMC4353658 DOI: 10.1155/2015/785638

Abstract

Osteoarthritis (OA) is a multifactorial disease primarily noted by cartilage degradation in association with inflammation that causes significant morbidity, joint pain, stiffness, and limited mobility. Present-day management of OA is inadequate due to the lack of principal therapies proven to be effective in hindering disease progression where symptomatic therapy focused approach masks the actual etiology leading to irreversible damage. Here, we describe the effect of UP3005, a composition containing a proprietary blend of two standardized extracts from the leaf of Uncaria gambir and the root bark of Morus alba, in maintaining joint structural integrity and alleviating OA associated symptoms in monosodium-iodoacetate- (MIA-) induced rat OA disease model. Pain sensitivity, micro-CT, histopathology, and glycosaminoglycans (GAGs) level analysis were conducted. Diclofenac at 10 mg/kg was used as a reference compound. UP3005 resulted in almost a complete inhibition in proteoglycans degradation, reductions of 16.6% (week 4), 40.5% (week 5), and 22.0% (week 6) in pain sensitivity, statistically significant improvements in articular cartilage matrix integrity, minimal visual subchondral bone damage, and statistically significant increase in bone mineral density when compared to the vehicle control with MIA. Therefore, UP3005 could potentially be considered as an alternative therapy from natural sources for the treatment of OA and/or its associated symptoms.

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