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Yang JC, Xu CX, Sun Y, et al. Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study. Exp Ther Med. 2015;10(1):37-42doi: 10.3892/etm.2015.2461.
Yang, J. C., Xu, C. X., Sun, Y., Dang, Q. L., Li, L., Xu, Y. G., Song, Y. J., & Yan, H. (2015). Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study. Experimental and therapeutic medicine, 10(1), 37-42. https://doi.org/10.3892/etm.2015.2461
Yang, Jiang-Cun, et al. "Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study." Experimental and therapeutic medicine vol. 10,1 (2015): 37-42. doi: https://doi.org/10.3892/etm.2015.2461
Yang JC, Xu CX, Sun Y, Dang QL, Li L, Xu YG, Song YJ, Yan H. Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study. Exp Ther Med. 2015 Jul;10(1):37-42. doi: 10.3892/etm.2015.2461. Epub 2015 Apr 30. PMID: 26170909; PMCID: PMC4486907.
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Exp Ther Med. 2015 Jul;10(1):37-42. doi: 10.3892/etm.2015.2461. Epub 2015 Apr 30.

Balanced ratio of plasma to packed red blood cells improves outcomes in massive transfusion: A large multicenter study.

Experimental and therapeutic medicine

Jiang-Cun Yang, Cui-Xiang Xu, Yang Sun, Qian-Li Dang, Ling Li, Yong-Gang Xu, Yao-Jun Song, Hong Yan

Affiliations

  1. Department of Transfusion Medicine, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
  2. Shaanxi Provincial Center for Clinical Laboratory, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
  3. Department of Dermatology, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
  4. Department of Laboratory, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
  5. Department of Urology, The Third Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.
  6. Department of Epidemiology and Health Statistics, Medical College of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China.

PMID: 26170909 PMCID: PMC4486907 DOI: 10.3892/etm.2015.2461

Abstract

Resuscitation with the early administration of plasma can improve the survival of patients undergoing surgery or trauma patients who require massive transfusion. To ascertain the optimal ratio of fresh frozen plasma (FFP) to packed red blood cells (pRBCs) in massive transfusions, the records of 1,048 patients who received a massive transfusion at 20 hospitals were retrospectively reviewed. The patients were stratified into three groups according to the ratio of FFP to pRBCs. These were the low (<1:2.3), middle (1:2.3-0.75) and high (≥1:0.75) ratio groups. For 24-h treatment, the middle FFP:pRBC ratio led to a lower mortality rate (9.31%) compared with that in the low (11.83%) and high (11.44%) ratio groups (P=0.477). For 72-h treatment, the middle FFP:pRBC ratio also lead to the lowest mortality rate (7.25%), which was significantly lower than the ratios in the low (10.39%) and high (13.65%) ratio groups (P=0.007). The length of hospital stay, ICU stay, and FFP:pRBC ratio in 72 h were found to be significant associated with mortality. The optimal ratio of FFP to pRBCs of 1:2.3-0.75 in 72 h can improve the survival of patients undergoing massive transfusions.

Keywords: fresh frozen plasma; packed red blood cells; surgical transfusion

References

  1. Best Pract Res Clin Anaesthesiol. 2010 Mar;24(1):51-64 - PubMed
  2. J Trauma. 2003 Mar;54(3):454-63 - PubMed
  3. Chest. 2009 Dec;136(6):1654-67 - PubMed
  4. J Trauma. 2007 Dec;63(6):1338-46; discussion 1346-7 - PubMed
  5. J Trauma. 2007 Oct;63(4):805-13 - PubMed
  6. J Trauma. 2003 Jul;55(1):39-44 - PubMed
  7. Ann Surg. 2008 Sep;248(3):447-58 - PubMed
  8. Can J Surg. 2005 Dec;48(6):470-8 - PubMed
  9. Yonsei Med J. 2011 May;52(3):469-75 - PubMed
  10. Am J Surg. 2009 May;197(5):565-70; discussion 570 - PubMed
  11. BMJ. 1990 Jan 13;300(6717):107-9 - PubMed
  12. Chest. 2010 Jan;137(1):209-20 - PubMed
  13. J Trauma. 2006 Jun;60(6 Suppl):S91-6 - PubMed
  14. Resuscitation. 2010 Sep;81(9):1079-81 - PubMed
  15. Br J Haematol. 2006 Dec;135(5):634-41 - PubMed
  16. Crit Care. 2011;15(1):R68 - PubMed
  17. Transfusion. 2010 Jun;50(6):1370-83 - PubMed
  18. Transfusion. 2004 Jun;44(6):809-13 - PubMed
  19. J Trauma. 2008 Feb;64(2 Suppl):S69-77; discussion S77-8 - PubMed
  20. J Am Coll Surg. 2009 Aug;209(2):198-205 - PubMed
  21. Arch Surg. 1999 Sep;134(9):964-8; discussion 968-70 - PubMed
  22. Vox Sang. 2009 Feb;96(2):111-8 - PubMed
  23. Transfus Med Rev. 2009 Oct;23(4):255-65 - PubMed
  24. Minerva Anestesiol. 2007 Jul-Aug;73(7-8):401-15 - PubMed
  25. Ann Surg. 2008 Oct;248(4):578-84 - PubMed
  26. Transfusion. 2010 Jul;50(7):1545-51 - PubMed
  27. BMJ. 2009 Jun 05;338:b1778 - PubMed
  28. J Trauma. 2008 Aug;65(2):272-6; discussion 276-8 - PubMed

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