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Zhang S, Wang Y, Jiang H, et al. Peroxisome proliferator-activated receptor gamma rs1801282 C>G polymorphism is associated with polycystic ovary syndrome susceptibility: a meta-analysis involving 7,069 subjects. Int J Clin Exp Med. 2015;8(10):17418-29
Zhang, S., Wang, Y., Jiang, H., Liu, C., Sun, B., Chen, S., Kang, M., & Tang, W. (2015). Peroxisome proliferator-activated receptor gamma rs1801282 C>G polymorphism is associated with polycystic ovary syndrome susceptibility: a meta-analysis involving 7,069 subjects. International journal of clinical and experimental medicine, 8(10), 17418-29.
Zhang, Sheng, et al. "Peroxisome proliferator-activated receptor gamma rs1801282 C>G polymorphism is associated with polycystic ovary syndrome susceptibility: a meta-analysis involving 7,069 subjects." International journal of clinical and experimental medicine vol. 8,10 (2015): 17418-29.
Zhang S, Wang Y, Jiang H, Liu C, Sun B, Chen S, Kang M, Tang W. Peroxisome proliferator-activated receptor gamma rs1801282 C>G polymorphism is associated with polycystic ovary syndrome susceptibility: a meta-analysis involving 7,069 subjects. Int J Clin Exp Med. 2015 Oct 15;8(10):17418-29. eCollection 2015. PMID: 26770332; PMCID: PMC4694232.
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Int J Clin Exp Med. 2015 Oct 15;8(10):17418-29. eCollection 2015.

Peroxisome proliferator-activated receptor gamma rs1801282 C>G polymorphism is associated with polycystic ovary syndrome susceptibility: a meta-analysis involving 7,069 subjects.

International journal of clinical and experimental medicine

Sheng Zhang, Yafeng Wang, Heping Jiang, Chao Liu, Bin Sun, Shuchen Chen, Mingqiang Kang, Weifeng Tang

Affiliations

  1. Department of General Surgery, Changzhou No. 3 People's Hospital Changzhou, Jiangsu Province, China.
  2. Department of Cardiology, The People's Hospital of Xishuangbanna Dai Autonomous Prefecture Jinghong, Yunnan Province, China.
  3. Emergency Department, Affiliated Jintan People's Hospital of Jiangsu University Jintan, China.
  4. Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University Zhenjiang, Jiangsu Province, China.
  5. Department of Thoracic Surgery, The Union Clinical Medical College of Fujian Medical University Fuzhou, Fujian Province, China.
  6. Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu UniversityZhenjiang, Jiangsu Province, China; Department of Thoracic Surgery, The Union Clinical Medical College of Fujian Medical UniversityFuzhou, Fujian Province, China.

PMID: 26770332 PMCID: PMC4694232

Abstract

In the peroxisome proliferator-activated receptor gamma (PPARG) gene, a polymorphism (rs1801282 C>G), has been shown to change an amino acid residue and then results in alternation of PPARG function. A number of studies have explored the relationship between PPARG rs1801282 C>G variants and polycystic ovary syndrome (PCOS) risk, but yielding inconsistent findings, especially in Asian population. This study aimed to assess the role of PPARG rs1801282 C>G polymorphism in susceptibility to PCOS. Databases of Pubmed, Embase and China National Knowledge Internet (CNKI) were searched until August 2, 2015. The association of PPARG 1801282 C>G polymorphism with PCOS risk was evaluated by crude odds ratios (ORs) with their 95% confidence intervals (CIs). Finally, there were twenty-three studies involving 3,458 PCOS cases and 3,611 controls included in our pooled analysis. Significant associations were identified between PPARG rs1801282 C>G variants and decreased PCOS risk in three genetic comparison models (OR, 0.78; 95% CI, 0.69-0.89; P < 0.001 for G vs. C; OR, 0.77; 95% CI, 0.68-0.89; P < 0.001 for GG+CG vs. CC and OR, 0.79; 95% CI, 0.68-0.91; P = 0.001 for CG vs. CC). In a subgroup analysis by race, significant correlation was also observed between PPARG rs1801282 C>G variants and decreased PCOS risk in three genetic models: G vs. C (OR, 0.83; 95% CI, 0.71-0.97; P = 0.019) and GG+CG vs. CC (OR, 0.83; 95% CI, 0.70-0.99; P = 0.033) among Caucasians and in one genetic models: G vs. C (OR, 0.72; 95% CI, 0.59-0.88; P = 0.001) among Asians. In summary, our results demonstrate that PPARG rs1801282 C>G polymorphism may be a protective factor for PCOS.

Keywords: Polycystic ovary syndrome; meta-analysis; peroxisome proliferator-activated receptor gamma; polymorphism

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