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So H, Ye BD, Park YS, et al. Gastric lesions in patients with Crohn's disease in Korea: a multicenter study. Intest Res. 2016;14(1):60-8doi: 10.5217/ir.2016.14.1.60.
So, H., Ye, B. D., Park, Y. S., Kim, J., Kim, J. S., Moon, W., Lee, K. M., Kim, Y. S., Keum, B., Kim, S. E., Kim, K. O., Kim, E. S., Lee, C. K., Hong, S. P., Im, J. P., Koo, J. S., Choi, C. H., Shin, J. E., Lee, B. I., Huh, K. C., Kim, Y. H., Kim, H. S., Park, Y. S., Han, D. S. (2016). Gastric lesions in patients with Crohn's disease in Korea: a multicenter study. Intestinal research, 14(1), 60-8. https://doi.org/10.5217/ir.2016.14.1.60
So, Hoonsub, et al. "Gastric lesions in patients with Crohn's disease in Korea: a multicenter study." Intestinal research vol. 14,1 (2016): 60-8. doi: https://doi.org/10.5217/ir.2016.14.1.60
So H, Ye BD, Park YS, Kim J, Kim JS, Moon W, Lee KM, Kim YS, Keum B, Kim SE, Kim KO, Kim ES, Lee CK, Hong SP, Im JP, Koo JS, Choi CH, Shin JE, Lee BI, Huh KC, Kim YH, Kim HS, Park YS, Han DS. Gastric lesions in patients with Crohn's disease in Korea: a multicenter study. Intest Res. 2016 Jan;14(1):60-8. doi: 10.5217/ir.2016.14.1.60. Epub 2016 Jan 26. PMID: 26884736; PMCID: PMC4754524.
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Intest Res. 2016 Jan;14(1):60-8. doi: 10.5217/ir.2016.14.1.60. Epub 2016 Jan 26.

Gastric lesions in patients with Crohn's disease in Korea: a multicenter study.

Intestinal research

Hoonsub So, Byong Duk Ye, Young Soo Park, Jihun Kim, Joo Sung Kim, Won Moon, Kang-Moon Lee, You Sun Kim, Bora Keum, Seong-Eun Kim, Kyeong Ok Kim, Eun Soo Kim, Chang Kyun Lee, Sung Pil Hong, Jong Pil Im, Ja Seol Koo, Chang Hwan Choi, Jeong Eun Shin, Bo In Lee, Kyu Chan Huh, Young-Ho Kim, Hyun-Soo Kim, Young Sook Park, Dong Soo Han,

Affiliations

  1. Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  2. Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.; Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  3. Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
  4. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
  5. Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.
  6. Department of Internal Medicine, The Catholic University of Korea, St. Vincent's Hospital, Suwon, Korea.
  7. Department of Internal Medicine, Inje University College of Medicine, Seoul Paik Hospital, Seoul, Korea.
  8. Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul, Korea.
  9. Department of Internal Medicine, Ewha Womans University School of Medicine, Ewha Mokdong Hospital, Seoul, Korea.
  10. Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.
  11. Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea.
  12. Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea.
  13. Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
  14. Department of Internal Medicine, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Korea.
  15. Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.
  16. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
  17. Department of Internal Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, Korea.
  18. Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.
  19. Department of Internal Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
  20. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
  21. Department of Internal Medicine, Eulji University School of Medicine, Seoul, Korea.
  22. Department of Internal Medicine, Hanyang University College of Medicine, Hanyang University Guri Hospital, Guri, Korea.

PMID: 26884736 PMCID: PMC4754524 DOI: 10.5217/ir.2016.14.1.60

Abstract

BACKGROUND/AIMS: Gastric pathology and Helicobacter pylori (H. pylori) infection among Asian patients with Crohn's disease (CD) are still unclear. We evaluated gastric histologic features and frequency of H. pylori infection in Korean patients with CD.

METHODS: Among 492 patients with CD receiving upper gastrointestinal (GI) endoscopic evaluation in 19 Korean hospitals, we evaluated the endoscopic findings and gastric histopathologic features of 47 patients for our study. Histopathologic classification was performed using gastric biopsy tissues, and H. pylori infection was determined using the rapid urease test and histology.

RESULTS: There were 36 men (76.6%), and the median age of patients at the time of upper GI endoscopy was 23.8 years (range, 14.2-60.5). For CD phenotype, ileocolonic disease was observed in 38 patients (80.9%), and non-stricturing, non-penetrating disease in 31 patients (66.0%). Twenty-eight patients (59.6%) complained of upper GI symptoms. Erosive gastritis was the most common gross gastric feature (66.0%). Histopathologically, H. pylori-negative chronic active gastritis (38.3%) was the most frequent finding. H. pylori testing was positive in 11 patients (23.4%), and gastric noncaseating granulomata were detected in 4 patients (8.5%). Gastric noncaseating granuloma showed a statistically significant association with perianal abscess/fistula (P=0.0496).

CONCLUSIONS: H. pylori-negative chronic active gastritis appears to be frequent among Korean patients with CD. The frequency of H. pylori infection was comparable with previous studies. An association with perianal complications suggests a prognostic value for gastric noncaseating granuloma in patients with CD.

Keywords: Crohn disease; Gastritis; Granuloma; Helicobacter pylori; Stomach

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