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Li Y, Liu N, Chen H, et al. Association of . Exp Ther Med. 2015;11(1):28-32doi: 10.3892/etm.2015.2898.
Li, Y., Liu, N., Chen, H., Huang, Y., & Zhang, W. (2016). Association of . Experimental and therapeutic medicine, 11(1), 28-32. https://doi.org/10.3892/etm.2015.2898
Li, Ying, et al. "Association of ." Experimental and therapeutic medicine vol. 11,1 (2016): 28-32. doi: https://doi.org/10.3892/etm.2015.2898
Li Y, Liu N, Chen H, Huang Y, Zhang W. Association of . Exp Ther Med. 2016 Jan;11(1):28-32. doi: 10.3892/etm.2015.2898. Epub 2015 Nov 26. PMID: 26889213; PMCID: PMC4726899.
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Exp Ther Med. 2016 Jan;11(1):28-32. doi: 10.3892/etm.2015.2898. Epub 2015 Nov 26.

Association of .

Experimental and therapeutic medicine

Ying Li, Nan Liu, Hui Chen, Yonghua Huang, Weiwei Zhang

Affiliations

  1. Postgraduate School, Third Military Medical University, Chongqing 400300, P.R. China; Department of Neurology, Military General Hospital of Beijing PLA, Beijing 100700, P.R. China.
  2. Department of Neurology, Military General Hospital of Beijing PLA, Beijing 100700, P.R. China.

PMID: 26889213 PMCID: PMC4726899 DOI: 10.3892/etm.2015.2898

Abstract

Cerebrovascular disease is a leading cause of morbidity and mortality worldwide, which is influenced by genetic and environmental factors. The aim of the present study was to examine the association between single-nucleotide polymorphisms (SNPs) in Notch3 exons 3-6 and lacunar infarction by comparing SNPs between control subjects and those with lacunar infarction. A single-center case-control study was conducted to investigate the association between Notch3 SNPs and risk of stroke. A total of 140 patients were included in the study, 30 of whom had no infarction (control) and 110 had lacunar infarction. Lacunar patients were divided into the 'pure lacunar' and 'lacunar + leukoarasis' groups based on brain imaging. All the patients were of Chinese Han ethnicity, and the male to female ratio was 84:56. Patient clinical histories included hypertension, diabetes mellitus (DM), hyperlipidemia, and heart disease were recorded. The Notch3 sequence was obtained from the National Centser for Biotechnology Information database. Notch3 was amplified by polymerase chain reaction from whole blood samples, and exons 3-6 were sequenced to identify SNPs. The result showed that there was no significant difference in the prevalence of hypertension, DM, hyperlipidemia, and heart disease between the control and lacunar infarction patients. Notabley, the age of the lacunar + leukoarasis patients was significantly higher than that of the control and pure lacunar patients (P<0.05). Eight SNPs were detected at low frequencies, and only rs3815388 and rs1043994 exhibited slightly higher frequencies. A χ

Keywords: Notch3 gene; cerebrovascular disease; infarction; lacunar; leukoaraiosis; single-nucleotide polymorphisms

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