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Murray KM, Parker W, Stephany H, et al. Venous thromboembolism after radical cystectomy: Experience with screening ultrasonography. Arab J Urol. 2015;14(1):37-43doi: 10.1016/j.aju.2015.11.002.
Murray, K. M., Parker, W., Stephany, H., Redger, K., Mirza, M., Lopez-Corona, E., Holzbeierlein, J. M., & Lee, E. K. (2016). Venous thromboembolism after radical cystectomy: Experience with screening ultrasonography. Arab journal of urology, 14(1), 37-43. https://doi.org/10.1016/j.aju.2015.11.002
Murray, Katie M, et al. "Venous thromboembolism after radical cystectomy: Experience with screening ultrasonography." Arab journal of urology vol. 14,1 (2016): 37-43. doi: https://doi.org/10.1016/j.aju.2015.11.002
Murray KM, Parker W, Stephany H, Redger K, Mirza M, Lopez-Corona E, Holzbeierlein JM, Lee EK. Venous thromboembolism after radical cystectomy: Experience with screening ultrasonography. Arab J Urol. 2016 Mar;14(1):37-43. doi: 10.1016/j.aju.2015.11.002. Epub 2015 Dec 29. PMID: 26966592; PMCID: PMC4767786.
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Arab J Urol. 2016 Mar;14(1):37-43. doi: 10.1016/j.aju.2015.11.002. Epub 2015 Dec 29.

Venous thromboembolism after radical cystectomy: Experience with screening ultrasonography.

Arab journal of urology

Katie M Murray, William Parker, Heidi Stephany, Kirk Redger, Moben Mirza, Ernesto Lopez-Corona, Jeffrey M Holzbeierlein, Eugene K Lee

Affiliations

  1. Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
  2. Mayo Clinic, Rochester, MN, USA.
  3. University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  4. University of Kansas Medical Center, Kansas City, KS, USA.

PMID: 26966592 PMCID: PMC4767786 DOI: 10.1016/j.aju.2015.11.002

Abstract

OBJECTIVES: To detect the incidence of immediate postoperative deep vein thrombosis (DVT) using screening lower extremity ultrasonography (US) in patients undergoing radical cystectomy (RC) and to determine the rate of symptomatic pulmonary embolism (PE) after RC and identify risk factors for venous thromboembolic (VTE) events in a RC population.

PATIENTS AND METHODS: We performed a retrospective review of prospective data collected on patients who underwent RC between July 2008 and January 2012. These patients underwent screening US at 2/3 days after RC to determine the rate of asymptomatic DVT. A chart review was completed to identify those who had a symptomatic PE. Univariate and multivariable analysis was used to identify risk factors associated with DVT, PE and total VTE events.

RESULTS: In all, 221 patients underwent RC and asymptomatic DVT was identified in 21 (9.5%) on screening US. Nine (4.5%) developed symptomatic PE at a median of 9 days, of which no patients had positive lower extremity US postoperatively. Increased length of hospital stay, increased estimated blood loss, and lower body mass index were linked to risk of PE, and only a previous history of DVT was associated with postoperative DVT.

CONCLUSION: Patients who undergo RC are at high-risk for thromboembolic events and multimodal prophylaxis should be administered. Clinicians should be especially vigilant in those who demonstrate factors associated with higher risk for VTE events.

Keywords: BMI, body mass index; DVT, deep vein thrombosis; Deep vein thrombosis; EBL, estimated blood loss; LMWH, low-molecular weight heparin; LOS, length of hospital stay; PE, pulmonary embolism; Pulmonary embolism; RC, radical cystectomy; Radical cystectomy; US, ultrasonography; Ultrasonography; VTE, venous thromboembolism; Venous thromboembolism

References

  1. J Urol. 2010 Sep;184(3):990-4; quiz 1235 - PubMed
  2. J Urol. 2006 Mar;175(3 Pt 1):886-9; discussion 889-90 - PubMed
  3. CMAJ. 2003 Jan 21;168(2):183-94 - PubMed
  4. J Urol. 2009 Sep;182(3):914-21 - PubMed
  5. J Urol. 2009 Mar;181(3):1170-7 - PubMed
  6. J Urol. 2010 Oct;184(4):1296-300 - PubMed
  7. N Engl J Med. 2002 Mar 28;346(13):975-80 - PubMed
  8. Chest. 2012 Feb;141(2 Suppl):e227S-77S - PubMed
  9. CA Cancer J Clin. 2013 Jan;63(1):11-30 - PubMed
  10. J Clin Oncol. 2001 Feb 1;19(3):666-75 - PubMed
  11. J Urol. 1997 Sep;158(3 Pt 1):869-71 - PubMed
  12. J Clin Oncol. 2007 Dec 1;25(34):5490-505 - PubMed
  13. Thromb Haemost. 2009 Jul;102(1):56-61 - PubMed
  14. Thromb Haemost. 2011 Sep;106(3):405-15 - PubMed
  15. Ann Surg Oncol. 2011 Nov;18(12):3240-7 - PubMed
  16. Arch Surg. 2011 Dec;146(12 ):1424-7 - PubMed
  17. Ann Intern Med. 1998 Apr 15;128(8):663-77 - PubMed
  18. Arch Intern Med. 2005 Jul 11;165(13):1458-64 - PubMed
  19. Eur Urol. 2009 Jan;55(1):164-74 - PubMed
  20. Prostate Cancer Prostatic Dis. 1997 Dec;1(2):101-104 - PubMed
  21. J Urol. 2011 Dec;186(6):2293-7 - PubMed

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