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Alosco ML, Tripodis Y, Jarnagin J, et al. Repetitive head impact exposure and later-life plasma total tau in former National Football League players. Alzheimers Dement (Amst). 2016;7:33-40doi: 10.1016/j.dadm.2016.11.003.
Alosco, M. L., Tripodis, Y., Jarnagin, J., Baugh, C. M., Martin, B., Chaisson, C. E., Estochen, N., Song, L., Cantu, R. C., Jeromin, A., & Stern, R. A. (2017). Repetitive head impact exposure and later-life plasma total tau in former National Football League players. Alzheimer's & dementia (Amsterdam, Netherlands), 733-40. https://doi.org/10.1016/j.dadm.2016.11.003
Alosco, Michael L, et al. "Repetitive head impact exposure and later-life plasma total tau in former National Football League players." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 7 (2017): 33-40. doi: https://doi.org/10.1016/j.dadm.2016.11.003
Alosco ML, Tripodis Y, Jarnagin J, Baugh CM, Martin B, Chaisson CE, Estochen N, Song L, Cantu RC, Jeromin A, Stern RA. Repetitive head impact exposure and later-life plasma total tau in former National Football League players. Alzheimers Dement (Amst). 2016 Dec 10;7:33-40. doi: 10.1016/j.dadm.2016.11.003. eCollection 2017. PMID: 28229128; PMCID: PMC5312499.
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Alzheimers Dement (Amst). 2016 Dec 10;7:33-40. doi: 10.1016/j.dadm.2016.11.003. eCollection 2017.

Repetitive head impact exposure and later-life plasma total tau in former National Football League players.

Alzheimer's & dementia (Amsterdam, Netherlands)

Michael L Alosco, Yorghos Tripodis, Johnny Jarnagin, Christine M Baugh, Brett Martin, Christine E Chaisson, Nate Estochen, Linan Song, Robert C Cantu, Andreas Jeromin, Robert A Stern

Affiliations

  1. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
  2. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  3. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA.
  4. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Interfaculty Initiative in Health Policy, Harvard University Boston, MA, USA.
  5. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
  6. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA; Data Coordinating Center, Boston University School of Public Health, Boston, MA, USA.
  7. Quanterix Corporation, Lexington, MA, USA.
  8. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA.
  9. Boston University Alzheimer's Disease and CTE Center, Boston University School of Medicine, Boston, MA, USA; Department of Neurology, Boston University School of Medicine, Boston, MA, USA; Department of Neurosurgery, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.

PMID: 28229128 PMCID: PMC5312499 DOI: 10.1016/j.dadm.2016.11.003

Abstract

INTRODUCTION: Blood protein analysis of total tau (t-tau) may be a practical screening biomarker for chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. We examined plasma t-tau in symptomatic former National Football League (NFL) players compared with controls and the relationship between RHI exposure and later-life plasma t-tau.

METHODS: Ninety-six former NFL players (age 40-69) and 25 same-age controls underwent blood draw to determine plasma t-tau levels. The cumulative head impact index (CHII) quantified RHI exposure. Subjects completed measures of clinical function.

RESULTS: A higher CHII predicted greater plasma t-tau in the former NFL players (

DISCUSSION: Greater RHI exposure predicted higher later-life plasma t-tau concentrations, and further study on plasma t-tau as a candidate screening biomarker for CTE is warranted.

Keywords: American football; Chronic traumatic encephalopathy; Head trauma; Plasma; Repetitive head impacts; Tau; Total tau

References

  1. Ann Biomed Eng. 2016 Dec;44(12):3679-3692 - PubMed
  2. Alzheimers Res Ther. 2014 Sep 24;6(5):68 - PubMed
  3. Methods. 2015 Oct 1;87:3-10 - PubMed
  4. Neurosurgery. 2014 Oct;75 Suppl 4:S24-33 - PubMed
  5. Brain Inj. 2013;27(4):425-33 - PubMed
  6. J Neurol. 2016 Jul;263(7):1332-41 - PubMed
  7. Alzheimers Dement. 2013 Jul;9(4):438-44 - PubMed
  8. Neurology. 2016 Aug 2;87(5):539-47 - PubMed
  9. Brain. 2013 Jan;136(Pt 1):43-64 - PubMed
  10. Exp Gerontol. 2010 Jan;45(1):30-40 - PubMed
  11. J Neurotrauma. 2017 Feb 15;34(4):772-780 - PubMed
  12. J Neurotrauma. 2017 Jan 15;34(2):328-340 - PubMed
  13. Mol Neurodegener. 2009 Mar 11;4:13 - PubMed
  14. J Neuropathol Exp Neurol. 2009 Jul;68(7):709-35 - PubMed
  15. Lancet Neurol. 2016 Jun;15(7):673-684 - PubMed
  16. Arch Neurol. 2012 Oct;69(10):1318-25 - PubMed
  17. Acta Neuropathol. 2015 Jul;130(1):21-34 - PubMed
  18. JAMA Neurol. 2014 Jun;71(6):684-92 - PubMed
  19. Acta Neuropathol. 2015 Dec;130(6):877-89 - PubMed
  20. Alzheimers Dement. 2011 May;7(3):257-62 - PubMed
  21. Neurobiol Aging. 2011 Dec;32(12):2131-41 - PubMed
  22. Acta Neuropathol. 2016 Jan;131(1):75-86 - PubMed
  23. ACS Chem Neurosci. 2013 Dec 18;4(12):1530-6 - PubMed
  24. Alzheimers Dement. 2015 Jun;11(6):e1-120 - PubMed
  25. JAMA Neurol. 2015 Oct;72(10):1109-16 - PubMed
  26. Neurosci Lett. 2001 Jan 19;297(3):187-90 - PubMed
  27. Trends Biotechnol. 2011 Jan;29(1):26-32 - PubMed
  28. Alzheimers Dement. 2015 Jul;11(7):772-91 - PubMed
  29. Hum Brain Mapp. 2014 Jul;35(7):3132-42 - PubMed
  30. Neurology. 2013 Sep 24;81(13):1122-9 - PubMed
  31. Alzheimer Dis Assoc Disord. 2013 Oct-Dec;27(4):337-42 - PubMed
  32. AJNR Am J Neuroradiol. 2003 Jan;24(1):52-7 - PubMed
  33. J Neurotrauma. 2017 Jan 15;34(2):372-379 - PubMed
  34. Ann Neurol. 2016 Jan;79(1):110-9 - PubMed
  35. Radiology. 2013 Sep;268(3):850-7 - PubMed
  36. Am J Pathol. 1994 Jul;145(1):175-88 - PubMed
  37. PLoS One. 2014 Apr 16;9(4):e94734 - PubMed
  38. J Alzheimers Dis. 2016;51(4):1099-109 - PubMed
  39. J Alzheimers Dis. 2015;45(4):1157-73 - PubMed
  40. Alzheimers Dement. 2016 Dec;12(12):1226-1234 - PubMed
  41. J Proteome Res. 2014 May 2;13(5):2649-58 - PubMed
  42. JAMA. 2012 Nov 14;308(18):1859-61 - PubMed
  43. J Magn Reson Imaging. 2006 Sep;24(3):537-42 - PubMed
  44. SAGE Open Med. 2015 Aug 10;3:2050312115598250 - PubMed
  45. Hum Brain Mapp. 2016 Feb;37(2):833-45 - PubMed
  46. Neurology. 2013 Jul 2;81(1):25-32 - PubMed
  47. Alzheimers Dement (Amst). 2015 Oct 03;1(4):412-9 - PubMed
  48. J Histochem Cytochem. 1989 Feb;37(2):209-15 - PubMed
  49. Alzheimers Dement. 2011 May;7(3):280-92 - PubMed
  50. Alzheimers Res Ther. 2013 Mar 28;5(2):9 - PubMed
  51. Neurology. 2015 Feb 17;84(7):729-37 - PubMed

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