Display options
Cite
Wang X, Ding J, Feng Y, et al. Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides. Oncol Lett. 2017;13(3):1509-1517doi: 10.3892/ol.2017.5602.
Wang, X., Ding, J., Feng, Y., Weng, L., Zhao, G., Xiang, J., Zhang, M., & Xing, D. (2017). Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides. Oncology letters, 13(3), 1509-1517. https://doi.org/10.3892/ol.2017.5602
Wang, Xuan, et al. "Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides." Oncology letters vol. 13,3 (2017): 1509-1517. doi: https://doi.org/10.3892/ol.2017.5602
Wang X, Ding J, Feng Y, Weng L, Zhao G, Xiang J, Zhang M, Xing D. Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides. Oncol Lett. 2017 Mar;13(3):1509-1517. doi: 10.3892/ol.2017.5602. Epub 2017 Jan 17. PMID: 28454283; PMCID: PMC5403668.
Copy Download .nbib Format: NLM
Share it on

Oncol Lett. 2017 Mar;13(3):1509-1517. doi: 10.3892/ol.2017.5602. Epub 2017 Jan 17.

Targeting of growth factors in the treatment of hepatocellular carcinoma: The potentials of polysaccharides.

Oncology letters

Xuan Wang, Jieyu Ding, Yuanyuan Feng, Lingling Weng, Guangqiang Zhao, Jianfeng Xiang, Minguang Zhang, Dongwei Xing

Affiliations

  1. Radiology Department, Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China.
  2. Oncology Department, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, P.R. China.

PMID: 28454283 PMCID: PMC5403668 DOI: 10.3892/ol.2017.5602

Abstract

Hepatocellular carcinoma (HCC) has become a leading cause of cancer-associated mortality worldwide and is thus of great concern. Although various chemotherapeutic drugs are currently used for the treatment of HCC, severe side effects associated with these treatments have prompted interest in novel therapies, including the use of certain biological macromolecules such as polysaccharides. Several studies have shown that polysaccharides have anticancer and antiproliferative effects on HCC. Vascular endothelial growth factor, transforming growth factor β, epidermal growth factor and fibroblast growth factor may be effective targets for polysaccharides and may modulate tumor growth and immunity through increasing the expression levels of cytokines. The present review focuses on the ways in which growth factors contribute to the development of HCC, and on the anti-growth factor activities of natural and synthetic polysaccharides, as well as their effect on proinflammatory cytokines.

Keywords: growth factors; hepatocellular carcinoma; polysaccharides

References

  1. PLoS One. 2012;7(3):e34406 - PubMed
  2. Surg Today. 2012 Jan;42(1):8-28 - PubMed
  3. Hepatogastroenterology. 2009 Mar-Apr;56(90):437-41 - PubMed
  4. Int J Biol Macromol. 2013 Nov;62:287-90 - PubMed
  5. Cancer Sci. 2006 Aug;97(8):689-96 - PubMed
  6. Hepatology. 2011 Mar;53(3):1020-2 - PubMed
  7. J Transl Med. 2011 Oct 10;9:171 - PubMed
  8. Phytomedicine. 2010 Jul;17(8-9):589-97 - PubMed
  9. Carbohydr Polym. 2012 Sep 1;90(1):67-72 - PubMed
  10. J Tradit Chin Med. 2014 Jun;34(3):309-16 - PubMed
  11. J Microbiol Biotechnol. 2008 Jan;18(1):95-103 - PubMed
  12. N Engl J Med. 1995 May 11;332(19):1294-6 - PubMed
  13. Invest New Drugs. 2010 Jun;28(3):276-83 - PubMed
  14. J Gastroenterol. 2012 May;47(5):504-18 - PubMed
  15. Biomaterials. 2014 May;35(15):4589-600 - PubMed
  16. Nat Rev Genet. 2007 Mar;8(3):173-84 - PubMed
  17. Nutr Cancer. 2014;66(6):989-98 - PubMed
  18. Food Chem. 2013 Dec 15;141(4):3415-23 - PubMed
  19. Oncogene. 2006 Jun 26;25(27):3787-800 - PubMed
  20. Cancer Res. 2001 Jul 15;61(14):5511-6 - PubMed
  21. Mol Cell Biochem. 2013 Sep;381(1-2):173-81 - PubMed
  22. Development. 2003 Jun;130(11):2513-24 - PubMed
  23. Int J Biol Macromol. 2017 Mar;96:26-34 - PubMed
  24. Curr Cancer Drug Targets. 2011 May;11(4):451-64 - PubMed
  25. Biomed Res Int. 2013;2013:964743 - PubMed
  26. Mol Med Rep. 2015 Mar;11(3):1609-14 - PubMed
  27. Carbohydr Polym. 2013 Sep 12;97(2):604-13 - PubMed
  28. Molecules. 2011 Sep 30;16(10):8343-52 - PubMed
  29. Carbohydr Polym. 2013 Jun 20;95(2):615-20 - PubMed
  30. Biol Trace Elem Res. 2016 Dec 9;:null - PubMed
  31. Immunol Lett. 2011 Dec 30;141(1):74-82 - PubMed
  32. Mol Med Rep. 2017 Jan;15(1):111-116 - PubMed
  33. Top Magn Reson Imaging. 2005 Feb;16(1):67-75 - PubMed
  34. J Ethnopharmacol. 2003 Feb;84(2-3):157-62 - PubMed
  35. Carbohydr Polym. 2013 Apr 2;93(2):395-400 - PubMed
  36. Adv Exp Med Biol. 2014;816:401-35 - PubMed
  37. Br J Cancer. 2009 May 5;100(9):1385-92 - PubMed
  38. Br J Cancer. 2008 Feb 12;98(3):580-6 - PubMed
  39. Int J Biol Macromol. 2012 May 1;50(4):1103-8 - PubMed
  40. CA Cancer J Clin. 2010 Sep-Oct;60(5):277-300 - PubMed
  41. Food Chem Toxicol. 2009 Jan;47(1):1-8 - PubMed
  42. Cell. 2000 Jan 7;100(1):57-70 - PubMed
  43. Integr Cancer Ther. 2013 Jan;12(1):50-68 - PubMed
  44. Toxicol Appl Pharmacol. 2006 Feb 1;210(3):236-45 - PubMed
  45. Liver Cancer. 2014 Mar;3(1):9-17 - PubMed
  46. Fitoterapia. 2008 Apr;79(3):168-73 - PubMed
  47. Food Chem Toxicol. 2012 Jul;50(7):2473-80 - PubMed
  48. Oncol Lett. 2014 Oct;8(4):1645-1651 - PubMed
  49. J Nucl Med. 2016 Nov;57(11):1811-1816 - PubMed
  50. J Gastroenterol Hepatol. 2008 Sep;23(9):1431-6 - PubMed
  51. Int J Biol Macromol. 2012 Oct;51(3):259-65 - PubMed
  52. J Pharm Pharmacol. 2011 Jun;63(6):825-32 - PubMed
  53. Carbohydr Polym. 2012 Nov 6;90(4):1395-410 - PubMed
  54. Am J Pathol. 2013 May;182(5):1648-58 - PubMed
  55. Fish Shellfish Immunol. 2016 Dec;59:196-202 - PubMed
  56. World J Gastroenterol. 2008 Jan 7;14(1):1-14 - PubMed
  57. Int J Biol Macromol. 2013 Oct;61:453-8 - PubMed
  58. Zhong Yao Cai. 2009 Apr;32(4):561-3 - PubMed
  59. Semin Thromb Hemost. 2007 Jul;33(5):557-68 - PubMed
  60. Curr Pharm Des. 2003;9(7):553-66 - PubMed
  61. Mech Dev. 2003 Jan;120(1):19-33 - PubMed
  62. Mol Cancer Ther. 2008 Oct;7(10 ):3129-40 - PubMed
  63. PLoS One. 2013 Nov 04;8(11):e76886 - PubMed
  64. World J Hepatol. 2013 Jul 27;5(7):345-52 - PubMed
  65. Nat Rev Drug Discov. 2009 Feb;8(2):129-38 - PubMed
  66. Lancet Oncol. 2009 Jan;10(1):25-34 - PubMed
  67. Afr J Tradit Complement Altern Med. 2013 Nov 02;11(1):15-22 - PubMed
  68. Atherosclerosis. 2011 Nov;219(1):84-91 - PubMed
  69. Hepatology. 1991 Sep;14(3):488-94 - PubMed
  70. Arch Pharm Res. 2009 Nov;32(11):1565-72 - PubMed
  71. Integr Cancer Ther. 2014 Sep;13(5):425-34 - PubMed
  72. Cancer Res. 2009 Sep 15;69(18):7385-92 - PubMed
  73. Semin Intervent Radiol. 2013 Mar;30(1):3-11 - PubMed
  74. J Ethnopharmacol. 2008 Mar 5;116(2):207-10 - PubMed
  75. Gastroenterology. 2004 Jan;126(1):231-48 - PubMed
  76. ScientificWorldJournal. 2011;11:2391-402 - PubMed
  77. Int J Biol Macromol. 2009 Nov 1;45(4):377-80 - PubMed
  78. World J Gastroenterol. 2012 Dec 21;18(47):7079-86 - PubMed
  79. PLoS One. 2015 Apr 27;10(4):e0124994 - PubMed
  80. Anticancer Res. 2009 Dec;29(12):5103-9 - PubMed
  81. Carcinogenesis. 2016 Dec;37(12 ):1117-1128 - PubMed
  82. Mol Cancer Ther. 2006 Apr;5(4):995-1006 - PubMed
  83. J Hepatol. 2012 Jul;57(1):108-15 - PubMed
  84. Oncol Lett. 2015 Jan;9(1):295-299 - PubMed
  85. Tumour Biol. 2014 Nov;35(11):10943-51 - PubMed
  86. Int J Biol Macromol. 2014 Mar;64:276-80 - PubMed
  87. Nat Rev Drug Discov. 2002 Feb;1(2):140-8 - PubMed
  88. Cell Biol Int. 2015 Jan;39(1):44-51 - PubMed
  89. Sci Rep. 2014 Apr 10;4:4628 - PubMed
  90. Int J Oncol. 2010 Jul;37(1):111-23 - PubMed
  91. J Hepatol. 2015 Apr;62(4):863-70 - PubMed
  92. Carbohydr Polym. 2013 Jan 30;92(1):479-83 - PubMed
  93. Crit Rev Oncol Hematol. 1996 Mar;22(2):89-126 - PubMed
  94. Am J Clin Pathol. 2008 Feb;129(2):245-51 - PubMed
  95. J Biochem. 2013 Jan;153(1):13-9 - PubMed
  96. Life Sci. 2012 Dec 10;91(23-24):1207-15 - PubMed
  97. J Zhejiang Univ Sci B. 2006 Dec;7(12):1006-14 - PubMed
  98. J Leukoc Biol. 2006 Dec;80(6):1197-213 - PubMed
  99. J Agric Food Chem. 2008 Aug 27;56(16):6905-9 - PubMed
  100. Hepatology. 2005 Jun;41(6):1233-40 - PubMed
  101. Exp Cell Res. 2006 Mar 10;312(5):549-60 - PubMed
  102. J Exp Med. 1998 Jul 20;188(2):341-50 - PubMed

Publication Types