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Bourel M, Guillouzo A, Guguen-Guillouzo C. Médicaments et culture d'hépatocytes. [Drugs and the culturing of hepatocytes]. Bull Acad Natl Med. 1989;173(4):409-12; discussion 412-4
Bourel, M., Guillouzo, A., & Guguen-Guillouzo, C. (1989). Médicaments et culture d'hépatocytes. [Drugs and the culturing of hepatocytes]. Bulletin de l'Academie nationale de medecine, 173(4), 409-12; discussion 412-4.
Bourel, M, et al. "Médicaments et culture d'hépatocytes." [Drugs and the culturing of hepatocytes]. Bulletin de l'Academie nationale de medecine vol. 173,4 (1989): 409-12; discussion 412-4.
Bourel M, Guillouzo A, Guguen-Guillouzo C. Médicaments et culture d'hépatocytes. [Drugs and the culturing of hepatocytes]. Bull Acad Natl Med. 1989 Apr;173(4):409-12; discussion 412-4. French. PMID: 2790528.
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Bull Acad Natl Med. 1989 Apr;173(4):409-12; discussion 412-4.

[Drugs and the culturing of hepatocytes].

Bulletin de l'Academie nationale de medecine

[Article in French]
M Bourel, A Guillouzo, C Guguen-Guillouzo

PMID: 2790528

Abstract

Two model systems are described for studying isolated hepatocytes in vitro: pure culture for short-term designs and co-culture with epithelial rat liver cells (for long duration procedures). Acute or chronic liver toxicities are discussed as well as indirect toxicities. Examples of species differences and genetic polymorphism are shown. Data on drugs used for the treatment of liver diseases are also presented.

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