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Zhao T, Liang J, Li T, et al. Serial stimulated thyroglobulin measurements are more specific for detecting distant metastatic differentiated thyroid cancer before radioiodine therapy. Chin J Cancer Res. 2017;29(3):213-222doi: 10.21147/j.issn.1000-9604.2017.03.07.
Zhao, T., Liang, J., Li, T., Gao, W., & Lin, Y. (2017). Serial stimulated thyroglobulin measurements are more specific for detecting distant metastatic differentiated thyroid cancer before radioiodine therapy. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 29(3), 213-222. https://doi.org/10.21147/j.issn.1000-9604.2017.03.07
Zhao, Teng, et al. "Serial stimulated thyroglobulin measurements are more specific for detecting distant metastatic differentiated thyroid cancer before radioiodine therapy." Chinese journal of cancer research = Chung-kuo yen cheng yen chiu vol. 29,3 (2017): 213-222. doi: https://doi.org/10.21147/j.issn.1000-9604.2017.03.07
Zhao T, Liang J, Li T, Gao W, Lin Y. Serial stimulated thyroglobulin measurements are more specific for detecting distant metastatic differentiated thyroid cancer before radioiodine therapy. Chin J Cancer Res. 2017 Jun;29(3):213-222. doi: 10.21147/j.issn.1000-9604.2017.03.07. PMID: 28729772; PMCID: PMC5497208.
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Chin J Cancer Res. 2017 Jun;29(3):213-222. doi: 10.21147/j.issn.1000-9604.2017.03.07.

Serial stimulated thyroglobulin measurements are more specific for detecting distant metastatic differentiated thyroid cancer before radioiodine therapy.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

Teng Zhao, Jun Liang, Tianjun Li, Wen Gao, Yansong Lin

Affiliations

  1. Department of Nuclear Medicine, Peking Union Medical College Hospital, Beijing 100730, China.
  2. Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

PMID: 28729772 PMCID: PMC5497208 DOI: 10.21147/j.issn.1000-9604.2017.03.07

Abstract

OBJECTIVE: Preablative stimulated thyroglobulin (ps-Tg) has the potential to be used in identifying distant metastatic differentiated thyroid carcinoma (DM-DTC), but its single level can be affected by remnant thyroid tissue and thyrotropin (TSH). The objective of this retrospective study was to evaluate the value of serial ps-Tg measurements in identifying DM-DTC specifically.

METHODS: A total of 317 DTC patients with serial measurements of ps-Tg, TSH and anti-Tg antibody were divided into M1 (n=72) and M0 (n=245) according to the presence of distant metastasis (DM) or not. The initial ps-Tg measurement, with a corresponding TSH exceeding 30 μIU/mL, was marked as Tg1, and ps-Tg measured right before radioactive iodine (RAI) therapy was defined as Tg2, with a median interval of 8 days. ΔTg denotes Tg2-Tg1, and ΔTSH denotes TSH2-TSH1. Tg1, Tg2, ΔTg, and ΔTg/ΔTSH were tested for efficacy in identifying DM-DTC using receiver operating characteristic (ROC) curve analysis, and further compared with chest computed tomography (CT) and posttreatment whole-body RAI scan (RxWBS).

RESULTS: Compared with single ps-Tg measurement (Tg1 or Tg2), both ΔTg and ΔTg/ΔTSH were more narrowly distributed around zero in the M0 group, which made their distribution in the M1 group more distinguished in a relatively dispersed way. ΔTg/ΔTSH manifested a higher accuracy (88.64%) and specificity (90.20%) in identifying DM-DTC than Tg1 or Tg2 measurements, with a much higher specificity than chest CT (90.20%

CONCLUSIONS: Serial ps-Tg measurements even over as short an interval as 8 days hold incremental value in identifying DM-DTC. ΔTg/ΔTSH is a specific early biochemical marker for DM-DTC.

Keywords: Neoplasm metastasis; iodine radioisotopes; thyroglobulin; thyroid cancer

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