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Tian Y, Yuan Wu NY, Liou YL, et al. Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women. Oncotarget. 2017;8(37):62274-62285doi: 10.18632/oncotarget.19459.
Tian, Y., Yuan Wu, N. Y., Liou, Y. L., Yeh, C. T., Cao, L., Kang, Y. N., Wang, H. J., Li, Y., Chu, T. Y., Li, W., Liu, X., Zhang, Y., Zhou, H., & Zhang, Y. (2017). Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women. Oncotarget, 8(37), 62274-62285. https://doi.org/10.18632/oncotarget.19459
Tian, Yan, et al. "Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women." Oncotarget vol. 8,37 (2017): 62274-62285. doi: https://doi.org/10.18632/oncotarget.19459
Tian Y, Yuan Wu NY, Liou YL, Yeh CT, Cao L, Kang YN, Wang HJ, Li Y, Chu TY, Li W, Liu X, Zhang Y, Zhou H, Zhang Y. Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women. Oncotarget. 2017 Jul 22;8(37):62274-62285. doi: 10.18632/oncotarget.19459. eCollection 2017 Sep 22. PMID: 28977944; PMCID: PMC5617504.
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Oncotarget. 2017 Jul 22;8(37):62274-62285. doi: 10.18632/oncotarget.19459. eCollection 2017 Sep 22.

Utility of gene methylation analysis, cytological examination, and HPV-16/18 genotyping in triage of high-risk human papilloma virus-positive women.

Oncotarget

Yan Tian, Na-Yi Yuan Wu, Yu-Ligh Liou, Ching-Tung Yeh, Lanqin Cao, Ya-Nan Kang, Huei-Jen Wang, Yichen Li, Tang-Yuan Chu, Wei Li, Xiang Liu, Yi Zhang, Honghao Zhou, Yu Zhang

Affiliations

  1. Department of Obstetrics & Gynecology, Xiangya Hospital, Hunan, P. R. China.
  2. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, P. R. China.
  3. Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, P. R. China.
  4. iStat Biomedical Co. Ltd., Taipei, Taiwan.
  5. Department of Obstetrics & Gynecology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
  6. Department of Obstetrics and Gynecology, ShengJing Hospital of China Medical University, Liaoning, P. R. China.
  7. Department of Pharmacy, Xiangtan Central Hospital, Xiangtan, P. R. China.

PMID: 28977944 PMCID: PMC5617504 DOI: 10.18632/oncotarget.19459

Abstract

In 2015, the American Society for Colposcopy and Cervical Pathology and the Society of Gynecologic Oncology issued interim guidance for the use of a human papillomavirus (HPV) test for primary screening, suggesting triage of women positive for high-risk human papillomavirus (hrHPV) by HPV-16/18 genotyping and cytology for women positive for non-16/18 hrHPV. The design of the present study was based on this interim guidance and analysis of the methylation status of specific candidate genes, which has been proposed as a tool to reduce unnecessary referral following primary HPV screening for cervical cancer. We performed a hospital-based case-control study including 312 hrHPV-positive women. hrHPV genotyping was performed by nested multiplex PCR assay with type-specific primers.Residual cervical cells from liquid-based cytology were used for extraction of genomic DNA for assessment of the methylation status of

Keywords: HPV triage; HPV16/18 genotyping; PAX1; ZNF582; cervical cancer

Conflict of interest statement

CONFLICTS OF INTEREST iStat Co., Ltd supported the production of testing kits for this project. Yu-Ligh Liou is a PhD student in the Department of Clinical Pharmacology, Xiangya Hospital, Central Sout

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