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Tong L, Liu P, Huo B, et al. CT-guided . Onco Targets Ther. 2017;10:4081-4088doi: 10.2147/OTT.S139571.
Tong, L., Liu, P., Huo, B., Guo, Z., & Ni, H. (2017). CT-guided . OncoTargets and therapy, 104081-4088. https://doi.org/10.2147/OTT.S139571
Tong, Lina, et al. "CT-guided ." OncoTargets and therapy vol. 10 (2017): 4081-4088. doi: https://doi.org/10.2147/OTT.S139571
Tong L, Liu P, Huo B, Guo Z, Ni H. CT-guided . Onco Targets Ther. 2017 Aug 17;10:4081-4088. doi: 10.2147/OTT.S139571. eCollection 2017. PMID: 28860816; PMCID: PMC5566505.
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Onco Targets Ther. 2017 Aug 17;10:4081-4088. doi: 10.2147/OTT.S139571. eCollection 2017.

CT-guided .

OncoTargets and therapy

Lina Tong, Ping Liu, Bin Huo, Zhi Guo, Hong Ni

Affiliations

  1. Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
  2. Department of Oncology, The Second Hospital of Tianjin Medical University, Tianjin, China.

PMID: 28860816 PMCID: PMC5566505 DOI: 10.2147/OTT.S139571

Abstract

OBJECTIVE: This retrospective study aimed to evaluate the feasibility, safety, and clinical efficacy of computed tomography (CT)-guided

METHODS: From March 2011 to December 2015, 35 pelvic recurrent lesions (33 patients) were reirradiated using this type of salvage therapy. The medical history, dose-volume histogram parameters, complications, local control, overall survival (OS), and affected factors were analyzed.

RESULTS: All patients were followed-up until expiration, and the median duration of follow-up was 16 months. The 1-, 3-, 6-, 12-, and 18-month local control rates were 84.5%, 74.2%, 60.0%, 55.5%, and 33.3%, respectively. The symptoms significantly improved after implantation. The median local tumor progression-free survival (LTPFS) and OS times were 7 months (range, 1-19 months) and 12 months (range, 2-42 months), respectively. The 1- and 2-year OS rates were 65.5% and 43.6%, respectively. In univariate analysis, a good performance status, a tumor diameter <4 cm, an interval time from last radiotherapy to seed implantation longer than 6 months and D90 (dose delivered to 90% of the target volume) ≥130 Gy were prognostic factors for LTPFS. Cox proportional hazards regression analysis revealed that tumor size and D90 were independent factors affecting LTPFS (

CONCLUSION: Reirradiation with CT-guided

Keywords: 125I seed; brachytherapy; cervical cancer; recurrent

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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