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Oncotarget. 2017 Sep 08;8(50):87455-87471. doi: 10.18632/oncotarget.20713. eCollection 2017 Oct 20.

Xenotransplantation of pediatric low grade gliomas confirms the enrichment of .

Oncotarget

Mari Kogiso, Lin Qi, Holly Lindsay, Yulun Huang, Xiumei Zhao, Zhigang Liu, Frank K Braun, Yuchen Du, Huiyuan Zhang, Goeun Bae, Sibo Zhao, Sarah G Injac, Mary Sobieski, David Brunell, Vidya Mehta, Diep Tran, Jeffrey Murray, Patricia A Baxter, Xiao-Jun Yuan, Jack M Su, Adekunle Adesina, Laszlo Perlaky, Murali Chintagumpala, D Williams Parsons, Ching C Lau, Clifford C Stephan, Xinyan Lu, Xiao-Nan Li

Affiliations

  1. Department of Pediatrics, Baylor College of Medicine, Texas Children's Cancer Center, Texas Children's Hospital, Houston, TX, USA.
  2. Department of Neurosurgery, The First Affiliated Hospital, Soochow University, Suzhou, China.
  3. Department of Ophthalmology, First Affiliated Hospital of Harbin, Medical University, Harbin, China.
  4. Department of Radiotherapy, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.
  5. Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M College of Medicine, Houston, TX, USA.
  6. Department of Pathology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
  7. Department of Hematology and Oncology, Cook Children's Medical Center, Fort Worth, TX, USA.
  8. Department of Hematology and Oncology, Xinhua Children's Hospital, Shanghai, China.
  9. Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

PMID: 29152094 PMCID: PMC5675646 DOI: 10.18632/oncotarget.20713

Abstract

To identify cellular and molecular changes that driver pediatric low grade glioma (PLGG) progression, we analyzed putative cancer stem cells (CSCs) and evaluated key biological changes in a novel and progressive patient-derived orthotopic xenograft (PDOX) mouse model. Flow cytometric analysis of 22 PLGGs detected CD133

Keywords: BRAF V600E; CDKN2A; cancer stem cell; low grade glioma; orthotopic xenograft

Conflict of interest statement

CONFLICTS OF INTEREST There is no conflict of interests for any author.

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