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Wang L, Gao X, Wei Y, et al. Coordinating Self-Assembly of Copper Perylenetetracarboxylate Nanorods: Selectively Lighting up Normal Cells around Cancerous Ones for Better Cancer Diagnosis. ACS Appl Mater Interfaces. 2018;10(21):17630-17638doi: 10.1021/acsami.8b03211.
Wang, L., Gao, X., Wei, Y., Liu, K., Huang, J., Wang, J., & Yan, Y. (2018). Coordinating Self-Assembly of Copper Perylenetetracarboxylate Nanorods: Selectively Lighting up Normal Cells around Cancerous Ones for Better Cancer Diagnosis. ACS applied materials & interfaces, 10(21), 17630-17638. https://doi.org/10.1021/acsami.8b03211
Wang, Lizhi, et al. "Coordinating Self-Assembly of Copper Perylenetetracarboxylate Nanorods: Selectively Lighting up Normal Cells around Cancerous Ones for Better Cancer Diagnosis." ACS applied materials & interfaces vol. 10,21 (2018): 17630-17638. doi: https://doi.org/10.1021/acsami.8b03211
Wang L, Gao X, Wei Y, Liu K, Huang J, Wang J, Yan Y. Coordinating Self-Assembly of Copper Perylenetetracarboxylate Nanorods: Selectively Lighting up Normal Cells around Cancerous Ones for Better Cancer Diagnosis. ACS Appl Mater Interfaces. 2018 May 30;10(21):17630-17638. doi: 10.1021/acsami.8b03211. Epub 2018 May 16. PMID: 29733187.
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ACS Appl Mater Interfaces. 2018 May 30;10(21):17630-17638. doi: 10.1021/acsami.8b03211. Epub 2018 May 16.

Coordinating Self-Assembly of Copper Perylenetetracarboxylate Nanorods: Selectively Lighting up Normal Cells around Cancerous Ones for Better Cancer Diagnosis.

ACS applied materials & interfaces

Lizhi Wang, Xuedong Gao, Ying Wei, Kaerdun Liu, Jianbin Huang, Jide Wang, Yun Yan

Affiliations

  1. Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education and Xinjiang Uygur Autonomous Region, College of Chemistry and Chemical Engineering , Xinjiang University , Urumqi 830046 , People's Republic of China.
  2. Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , People's Republic of China.

PMID: 29733187 DOI: 10.1021/acsami.8b03211

Abstract

Specific imaging of cancer cells has been well-accepted in cancer diagnosis although it cannot precisely mark the boundary between the normal and cancerous cells and report their mutual influence. We report a nanorod fluorescent probe of copper perylenetetracarbonate (PTC-Cu) that can specifically light up normal cells. In combination with cancer cell imaging, the cocultured normal and cancer cells can be lit up with different colors, offering a clear contrast between the normal and cancer cells when they coexist. Because cancerous cells are only 20-30% in cancer area, this provides a possibility to visibly detect the mutual influence between the cancer and normal cells during therapy. We expect this method is beneficial to better cancer diagnosis and therapy.

Keywords: Perylenetetracarboxylate; cell imaging; coordination; fluorescent probe; nanorods; selective stain; self-assembly

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