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Sun H, Wang X, Chen J, et al. Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. Int J Endocrinol. 2018;2018:2304746doi: 10.1155/2018/2304746.
Sun, H., Wang, X., Chen, J., Gusdon, A. M., Song, K., Li, L., & Qu, S. (2018). Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. International journal of endocrinology, 20182304746. https://doi.org/10.1155/2018/2304746
Sun, Hang, et al. "Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans." International journal of endocrinology vol. 2018 (2018): 2304746. doi: https://doi.org/10.1155/2018/2304746
Sun H, Wang X, Chen J, Gusdon AM, Song K, Li L, Qu S. Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans. Int J Endocrinol. 2018 Mar 12;2018:2304746. doi: 10.1155/2018/2304746. eCollection 2018. PMID: 29706998; PMCID: PMC5867607.
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Int J Endocrinol. 2018 Mar 12;2018:2304746. doi: 10.1155/2018/2304746. eCollection 2018.

Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans.

International journal of endocrinology

Hang Sun, Xingchun Wang, Jiaqi Chen, Aaron M Gusdon, Kexiu Song, Liang Li, Shen Qu

Affiliations

  1. Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, China.
  2. Department of Endocrinology and Metabolism, SuZhou Municipal Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China.
  3. Division of Neuropathology, Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.
  4. Department of Neurology, Weill Cornell Medical College, New York, NY 10065, USA.

PMID: 29706998 PMCID: PMC5867607 DOI: 10.1155/2018/2304746

Abstract

OBJECTIVE: This study aimed to determine the effects of melatonin on insulin resistance in obese patients with acanthosis nigricans (AN).

METHODS: A total of 17 obese patients with acanthosis nigricans were recruited in a 12-week pilot open trial. Insulin sensitivity, glucose metabolism, inflammatory factors, and other biochemical parameters before and after the administration of melatonin were measured.

RESULTS: After 12 weeks of treatment with melatonin (3 mg/day), homeostasis model assessment insulin resistance index (HOMA-IR) (8.99 ± 5.10 versus 7.77 ± 5.21,

CONCLUSIONS: It was concluded that melatonin could improve cutaneous symptoms in obese patients with acanthosis nigricans by improving insulin sensitivity and inflammatory status. This trial is registered with ClinicalTrials.gov NCT02604095.

References

  1. Indian Dermatol Online J. 2014 Jul;5(3):239-49 - PubMed
  2. J Drugs Dermatol. 2006 Oct;5(9):884-9 - PubMed
  3. J Pineal Res. 2015 Nov;59(4):403-19 - PubMed
  4. Clin Endocrinol (Oxf). 2016 Mar;84(3):342-7 - PubMed
  5. Arch Dermatol. 1992 Jul;128(7):941-4 - PubMed
  6. Am J Clin Dermatol. 2004;5(3):199-203 - PubMed
  7. Biochem Pharmacol. 2002 Feb 15;63(4):587-95 - PubMed
  8. J Invest Dermatol. 1997 Dec;109(6):770-7 - PubMed
  9. Ann Clin Biochem. 2006 Sep;43(Pt 5):344-53 - PubMed
  10. Diabetes Care. 1999 Sep;22(9):1462-70 - PubMed
  11. J Pineal Res. 2015 Jan;58(1):1-11 - PubMed
  12. Diabetes Care. 2004 Jun;27(6):1412-6 - PubMed
  13. World Health Organ Tech Rep Ser. 2000;894:i-xii, 1-253 - PubMed
  14. J Am Acad Dermatol. 1994 Jul;31(1):1-19; quiz 20-2 - PubMed
  15. Int J Mol Sci. 2013 Jan 24;14(2):2410-30 - PubMed
  16. Nature. 2006 Dec 14;444(7121):860-7 - PubMed
  17. Endocrinology. 2009 Dec;150(12):5311-7 - PubMed
  18. Int J Mol Sci. 2013 Mar 27;14(4):6981-7015 - PubMed
  19. J Pineal Res. 2015 Mar;58(2):166-72 - PubMed
  20. J Pineal Res. 2008 Jan;44(1):88-94 - PubMed
  21. Clin Dermatol. 2015 Jul-Aug;33(4):466-70 - PubMed
  22. Diabetes Care. 2007 Dec;30(12):2989-92 - PubMed
  23. J Am Acad Dermatol. 2007 Sep;57(3):502-8 - PubMed
  24. J Pineal Res. 2014 Sep;57(2):131-46 - PubMed
  25. Exp Clin Cardiol. 2006 Spring;11(1):14-20 - PubMed
  26. J Pineal Res. 2015 Oct;59(3):277-91 - PubMed
  27. Diabetes Care. 1999 Oct;22(10):1655-9 - PubMed
  28. J Pineal Res. 2015 Aug;59(1):1-23 - PubMed
  29. Obes Rev. 2011 Mar;12(3):167-88 - PubMed
  30. Cell. 2015 Sep 10;162(6):1212-4 - PubMed
  31. J Pineal Res. 2013 Jan;54(1):1-14 - PubMed
  32. JAMA. 2001 Jul 18;286(3):327-34 - PubMed
  33. Dermatol Online J. 2008 Sep 15;14(9):2 - PubMed
  34. Clin Nutr. 2009 Feb;28(1):46-51 - PubMed
  35. Br J Pharmacol. 2014 Jan;171(1):186-201 - PubMed
  36. Lipids Health Dis. 2015 Jul 22;14:75 - PubMed
  37. Recent Pat Endocr Metab Immune Drug Discov. 2013 Jan;7(1):11-25 - PubMed
  38. World J Diabetes. 2011 Jun 15;2(6):82-91 - PubMed
  39. Diabetes Care. 1996 Oct;19(10):1138-41 - PubMed
  40. Pediatrics. 2001 Apr;107(4):E55 - PubMed
  41. J Clin Invest. 1995 May;95(5):2409-15 - PubMed

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