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Peloso GM, van der Lee SJ, et al. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. Alzheimers Dement (Amst). 2018;10:595-598doi: 10.1016/j.dadm.2018.08.008.
Peloso, G. M., van der Lee, S. J., Destefano, A. L., & Seshardi, S. (2018). Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands), 10595-598. https://doi.org/10.1016/j.dadm.2018.08.008
Peloso, Gina M, et al. "Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 10 (2018): 595-598. doi: https://doi.org/10.1016/j.dadm.2018.08.008
Peloso GM, van der Lee SJ, Destefano AL, Seshardi S. Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease. Alzheimers Dement (Amst). 2018 Sep 22;10:595-598. doi: 10.1016/j.dadm.2018.08.008. eCollection 2018. PMID: 30422133; PMCID: PMC6215982.
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Alzheimers Dement (Amst). 2018 Sep 22;10:595-598. doi: 10.1016/j.dadm.2018.08.008. eCollection 2018.

Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Gina M Peloso, Sven J van der Lee, Anita L Destefano, Sudha Seshardi

Affiliations

  1. Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
  2. Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands.
  3. NHLBI's Framingham Heart Study, Framingham, MA, USA.
  4. Department of Neurology, Boston University School of Medicine, Boston, MA, USA.
  5. Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.

PMID: 30422133 PMCID: PMC6215982 DOI: 10.1016/j.dadm.2018.08.008

Abstract

INTRODUCTION: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (

METHODS: Ten single nucleotide polymorphisms within the

RESULTS: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the

DISCUSSION: Our study does not support the role of HDL-C on risk of AD through HDL-C altered by

Keywords: Cholesteryl ester transfer protein; Genetics; HDL-C; Instrumental variables; Single nucleotide polymorphisms

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