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Sinha R, Ahsan H, Blaser M, et al. Next steps in studying the human microbiome and health in prospective studies, Bethesda, MD, May 16-17, 2017. Microbiome. 2018;6(1):210doi: 10.1186/s40168-018-0596-z.
Sinha, R., Ahsan, H., Blaser, M., Caporaso, J. G., Carmical, J. R., Chan, A. T., Fodor, A., Gail, M. H., Harris, C. C., Helzlsouer, K., Huttenhower, C., Knight, R., Kong, H. H., Lai, G. Y., Hutchinson, D. L. S., Le Marchand, L., Li, H., Orlich, M. J., Shi, J., Truelove, A., Verma, M., Vogtmann, E., White, O., Willett, W., Zheng, W., Mahabir, S., & Abnet, C. (2018). Next steps in studying the human microbiome and health in prospective studies, Bethesda, MD, May 16-17, 2017. Microbiome, 6(1), 210. https://doi.org/10.1186/s40168-018-0596-z
Sinha, Rashmi, et al. "Next steps in studying the human microbiome and health in prospective studies, Bethesda, MD, May 16-17, 2017." Microbiome vol. 6,1 (2018): 210. doi: https://doi.org/10.1186/s40168-018-0596-z
Sinha R, Ahsan H, Blaser M, Caporaso JG, Carmical JR, Chan AT, Fodor A, Gail MH, Harris CC, Helzlsouer K, Huttenhower C, Knight R, Kong HH, Lai GY, Hutchinson DLS, Le Marchand L, Li H, Orlich MJ, Shi J, Truelove A, Verma M, Vogtmann E, White O, Willett W, Zheng W, Mahabir S, Abnet C. Next steps in studying the human microbiome and health in prospective studies, Bethesda, MD, May 16-17, 2017. Microbiome. 2018 Nov 26;6(1):210. doi: 10.1186/s40168-018-0596-z. PMID: 30477563; PMCID: PMC6257978.
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Microbiome. 2018 Nov 26;6(1):210. doi: 10.1186/s40168-018-0596-z.

Next steps in studying the human microbiome and health in prospective studies, Bethesda, MD, May 16-17, 2017.

Microbiome

Rashmi Sinha, Habibul Ahsan, Martin Blaser, J Gregory Caporaso, Joseph Russell Carmical, Andrew T Chan, Anthony Fodor, Mitchell H Gail, Curtis C Harris, Kathy Helzlsouer, Curtis Huttenhower, Rob Knight, Heidi H Kong, Gabriel Y Lai, Diane Leigh Smith Hutchinson, Loic Le Marchand, Hongzhe Li, Michael J Orlich, Jianxin Shi, Ann Truelove, Mukesh Verma, Emily Vogtmann, Owen White, Walter Willett, Wei Zheng, Somdat Mahabir, Christian Abnet

Affiliations

  1. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA. [email protected].
  2. Comprehensive Cancer Center University of Chicago Medicine and Biological Sciences, Chicago, IL, 60615, USA.
  3. Departments of Medicine and Microbiology, New York University Langone Medical Center, New York, NY, 10016, USA.
  4. Pathogen and Microbiome Institute and Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, 86011, USA.
  5. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.
  6. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
  7. Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, 02114, USA.
  8. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, 02115, USA.
  9. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
  10. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA.
  11. Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA.
  12. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA.
  13. Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  14. Division of Cancer Control and Population Sciences, National Cancer Institute, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  15. Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA.
  16. Center for Microbiome Innovation, and Departments of Pediatrics and Computer Science and Engineering, University of California San Diego, San Diego, CA, 92093, USA.
  17. Dermatology Branch, National Cancer Institute, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
  18. Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, 20892, USA.
  19. Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA.
  20. Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.
  21. Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.
  22. School of Public Health and Department of Preventive Medicine, School of Medicine, Loma Linda University, Loma Linda, CA, 92350, USA.
  23. Westat, Rockville, MD, 20850, USA.
  24. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
  25. Departments of Epidemiology and Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
  26. Division of Epidemiology, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.

PMID: 30477563 PMCID: PMC6257978 DOI: 10.1186/s40168-018-0596-z

Abstract

The National Cancer Institute (NCI) sponsored a 2-day workshop, "Next Steps in Studying the Human Microbiome and Health in Prospective Studies," in Bethesda, Maryland, May 16-17, 2017. The workshop brought together researchers in the field to discuss the challenges of conducting microbiome studies, including study design, collection and processing of samples, bioinformatics and statistical methods, publishing results, and ensuring reproducibility of published results. The presenters emphasized the great potential of microbiome research in understanding the etiology of cancer. This report summarizes the workshop and presents practical suggestions for conducting microbiome studies, from workshop presenters, moderators, and participants.

Keywords: Biospecimen; Cancer; Cohort; Epidemiology; Microbiome; Prospective

References

  1. Am J Epidemiol. 2017 Jan 15;185(2):115-123 - PubMed
  2. mSystems. 2016 May 3;1(3): - PubMed
  3. J Microbiol Biol Educ. 2016 Mar 01;17(1):46-50 - PubMed
  4. PLoS One. 2016 May 12;11(5):e0155362 - PubMed
  5. Nature. 2014 May 15;509(7500):357-60 - PubMed
  6. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2329-38 - PubMed
  7. Science. 2015 Sep 4;349(6252):1101-1106 - PubMed
  8. Nature. 2014 Jan 30;505(7485):612-3 - PubMed
  9. Genome Biol. 2015 Dec 09;16:276 - PubMed
  10. Nat Biotechnol. 2014 Sep;32(9):903-14 - PubMed
  11. Nat Biotechnol. 2006 Sep;24(9):1151-61 - PubMed
  12. BMC Biol. 2014 Nov 12;12:87 - PubMed
  13. Gut. 2018 May;67(5):882-891 - PubMed
  14. Science. 2016 Aug 19;353(6301):741-3 - PubMed
  15. Cancer Epidemiol Biomarkers Prev. 2016 Feb;25(2):407-16 - PubMed
  16. Nature. 2017 May 3;545(7652):116 - PubMed
  17. MBio. 2016 Aug 23;7(4): - PubMed
  18. Nat Biotechnol. 2017 Nov;35(11):1077-1086 - PubMed
  19. BMC Microbiol. 2015 Mar 21;15:66 - PubMed
  20. PLoS Comput Biol. 2016 Jul 11;12(7):e1004977 - PubMed
  21. Appl Environ Microbiol. 2017 May 1;83(10): - PubMed
  22. Gastroenterology. 2014 May;146(6):1564-72 - PubMed
  23. Cancer Epidemiol Biomarkers Prev. 2016 Nov;25(11):1483-1490 - PubMed
  24. Gut. 2016 May;65(5):740-8 - PubMed
  25. Nature. 2014 Jan 23;505(7484):559-63 - PubMed
  26. J Invest Dermatol. 2017 Mar;137(3):561-568 - PubMed
  27. N Engl J Med. 2003 Aug 28;349(9):868-74 - PubMed
  28. mSystems. 2016 Oct 18;1(5): - PubMed
  29. PLoS One. 2014 Jan 08;9(1):e84689 - PubMed

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