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Zhu J, Tian Z, Li Y, et al. ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability. Adv Sci (Weinh). 2019;6(8):1801927doi: 10.1002/advs.201801927.
Zhu, J., Tian, Z., Li, Y., Hua, X., Zhang, D., Li, J., Jin, H., Xu, J., Chen, W., Niu, B., Wu, X. R., Comincini, S., Huang, H., & Huang, C. (2019). ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 6(8), 1801927. https://doi.org/10.1002/advs.201801927
Zhu, Junlan, et al. "ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. 6,8 (2019): 1801927. doi: https://doi.org/10.1002/advs.201801927
Zhu J, Tian Z, Li Y, Hua X, Zhang D, Li J, Jin H, Xu J, Chen W, Niu B, Wu XR, Comincini S, Huang H, Huang C. ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability. Adv Sci (Weinh). 2019 Feb 22;6(8):1801927. doi: 10.1002/advs.201801927. eCollection 2019 Apr 17. PMID: 31016112; PMCID: PMC6468970.
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Adv Sci (Weinh). 2019 Feb 22;6(8):1801927. doi: 10.1002/advs.201801927. eCollection 2019 Apr 17.

ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Junlan Zhu, Zhongxian Tian, Yang Li, Xiaohui Hua, Dongyun Zhang, Jingxia Li, Honglei Jin, Jiheng Xu, Wei Chen, Beifang Niu, Xue-Ru Wu, Sergio Comincini, Haishan Huang, Chuanshu Huang

Affiliations

  1. Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms Key Laboratory of Laboratory Medicine Ministry of Education School of Laboratory Medicine and Life Sciences Wenzhou Medical University Wenzhou Zhejiang 325035 China.
  2. Department of Environmental Medicine New York University School of Medicine New York NY 10010 USA.
  3. Department of High-Performance Computing Technology and Application Development Computer Network Information Center Chinese Academy of Sciences Beijing 100190 China.
  4. Departments of Urology and Pathology New York University School of Medicine New York NY 10016 USA.
  5. VA Medical Center in Manhattan New York NY 10010 USA.
  6. Department of Biology and Biotechnology University of Pavia 27100 Pavia Italy.

PMID: 31016112 PMCID: PMC6468970 DOI: 10.1002/advs.201801927

Abstract

Since invasive bladder cancer (BC) can progress to life threatening metastases, understanding the molecular mechanisms underlying BC invasion is crucial for potentially decreasing the mortality of this disease. Herein, it is discovered that autophagy-related gene 7 (ATG7) is remarkably overexpressed in human invasive BC tissues. The knockdown of ATG7 in human BC cells dramatically inhibits cancer cell invasion, revealing that ATG7 is a key player in regulating BC invasion. Mechanistic studies indicate that MIR190A is responsible for ATG7 mRNA stability and protein overexpression by directly binding to ATG7 mRNA 3'-UTR. Furthermore, ATG7-mediated autophagy promotes HNRNPD (ARE/poly(U)-binding/degradation factor 1) protein degradation, and in turn reduces HNRNPD interaction with ARHGDIB mRNA, resulting in the elevation of ARHGDIB mRNA stability, and subsequently leading to BC cell invasion. The identification of the MIR190A/ATG7 autophagic mechanism regulation of HNRNPD/ARHGDIB expression provides an important insight into understanding the nature of BC invasion and suggests that autophagy may represent a potential therapeutic strategy for the treatment of human BC patients.

Keywords: ARHGDIB; ATG7; autophagy; bladder cancer; cancer invasion

Conflict of interest statement

The authors declare no conflict of interest.

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