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Mulvihill E, Ardoin S, Thompson SD, et al. Elevated serum complement levels and higher gene copy number of complement . Lupus Sci Med. 2019;6(1):e000333doi: 10.1136/lupus-2019-000333.
Mulvihill, E., Ardoin, S., Thompson, S. D., Zhou, B., Yu, G. R., King, E., Singer, N., Levy, D. M., Brunner, H., Wu, Y. L., Nagaraja, H. N., Schanberg, L. E., & Yu, C. Y. (2019). Elevated serum complement levels and higher gene copy number of complement . Lupus science & medicine, 6(1), e000333. https://doi.org/10.1136/lupus-2019-000333
Mulvihill, Evan, et al. "Elevated serum complement levels and higher gene copy number of complement ." Lupus science & medicine vol. 6,1 (2019): e000333. doi: https://doi.org/10.1136/lupus-2019-000333
Mulvihill E, Ardoin S, Thompson SD, Zhou B, Yu GR, King E, Singer N, Levy DM, Brunner H, Wu YL, Nagaraja HN, Schanberg LE, Yu CY. Elevated serum complement levels and higher gene copy number of complement . Lupus Sci Med. 2019 Jul 31;6(1):e000333. doi: 10.1136/lupus-2019-000333. eCollection 2019. PMID: 31448126; PMCID: PMC6687033.
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Lupus Sci Med. 2019 Jul 31;6(1):e000333. doi: 10.1136/lupus-2019-000333. eCollection 2019.

Elevated serum complement levels and higher gene copy number of complement .

Lupus science & medicine

Evan Mulvihill, Stacy Ardoin, Susan D Thompson, Bi Zhou, Gakit Richard Yu, Emily King, Nora Singer, D M Levy, Hermine Brunner, Yee Ling Wu, Haikady N Nagaraja, Laura Eve Schanberg, Chack-Yung Yu

Affiliations

  1. Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.
  2. Division of Rheumatology, Nationwide Children's Hospitatl, Columbus, OH, USA.
  3. Department of Pediatrics, The Ohio State University, Columbus, Ohio, USA.
  4. Center for Autoimmune Genomics and Etiology, Cincinnati Children's Hospital Medical Centre, Cincinnati, Ohio, USA.
  5. Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Columbus, Ohio, USA.
  6. Department of Medicine, University Hospitals/Case Medical Center, Cleveland, Ohio, USA.
  7. Department of Rheumatology, Hospital for Sick Children and Univeristy of Toronto, Toronto, Ontario, Canada.
  8. Department of Pediatrics, University of Cincinnati, Cincinnati Children's Hospital Medical Center, PRCSG Coordinating Center, Cincinnati, Ohio, USA.
  9. Department of Medical Microbiology and Immunology, Loyola University Chicago, Chicago, Illinois, USA.
  10. Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, Ohio, USA.
  11. Department of Pediatrics, Duke University, Durham, North Carolina, USA.
  12. Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.

PMID: 31448126 PMCID: PMC6687033 DOI: 10.1136/lupus-2019-000333

Abstract

OBJECTIVE: Systemic lupus erythematosus (SLE) features high frequency of cardiovascular disease (CVD) and fluctuating complement levels. The clinical trial Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) aimed to evaluate whether atorvastatin treatment reduced the progression of atherosclerosis in 221 patients with childhood-onset SLE (cSLE), using carotid intima media thickness (CIMT) as surrogates. We leveraged APPLE biorepository and trial data to investigate the relationship between

METHODS: Gene copy numbers (GCNs) for total

RESULTS: At baseline, C4 protein levels strongly correlated with GCNs of total

CONCLUSIONS: cSLE with hypertension had elevated serum levels of C4 and C3 and higher GCN of

Keywords: atherosclerosis; atorvastatin; complement C4 and C3; gene copy number variation; hypertension

Conflict of interest statement

Competing interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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