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Xu J, Fan W, Budoff MJ, et al. Intermittent Nonhabitual Coffee Consumption and Risk of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis. J Atr Fibrillation. 2019;12(1):2205doi: 10.4022/jafib.2205.
Xu, J., Fan, W., Budoff, M. J., Heckbert, S. R., Amsterdam, E. A., Alonso, A., & Wong, N. D. (2019). Intermittent Nonhabitual Coffee Consumption and Risk of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis. Journal of atrial fibrillation, 12(1), 2205. https://doi.org/10.4022/jafib.2205
Xu, Jennifer, et al. "Intermittent Nonhabitual Coffee Consumption and Risk of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis." Journal of atrial fibrillation vol. 12,1 (2019): 2205. doi: https://doi.org/10.4022/jafib.2205
Xu J, Fan W, Budoff MJ, Heckbert SR, Amsterdam EA, Alonso A, Wong ND. Intermittent Nonhabitual Coffee Consumption and Risk of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis. J Atr Fibrillation. 2019 Jun 30;12(1):2205. doi: 10.4022/jafib.2205. eCollection 2019 Jun. PMID: 31687073; PMCID: PMC6811341.
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J Atr Fibrillation. 2019 Jun 30;12(1):2205. doi: 10.4022/jafib.2205. eCollection 2019 Jun.

Intermittent Nonhabitual Coffee Consumption and Risk of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis.

Journal of atrial fibrillation

Jennifer Xu, Wenjun Fan, Matthew J Budoff, Susan R Heckbert, Ezra A Amsterdam, Alvaro Alonso, Nathan D Wong

Affiliations

  1. University of California, Irvine Division of Cardiology, C240 Medical Sciences Irvine, CA 92629.
  2. Los Angeles Biomedical Research Institute, 1124 West Carson Street, Torrance, CA 90502.
  3. University of Washington Department of Epidemiology, Box 358085, 1730 Minor Avenue, Suite 1360, Seattle WA 98101.
  4. University of California Davis Medical Center Division of Cardiovascular Medicine, 4860 Y Street #2820, Sacramento, CA 95817.
  5. Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322.

PMID: 31687073 PMCID: PMC6811341 DOI: 10.4022/jafib.2205

Abstract

BACKGROUND: Though it is a widely held belief that caffeinated beverages predispose individuals to arrhythmias, it is not clear whether regular coffee consumption is associated with development of atrial fibrillation (AF).

OBJECTIVE: We examined the association between long-term coffee consumption and development of AF in both habitual (≥0.5 cups of daily coffee) and nonhabitual (<0.5 cups/day) drinkers.

METHODS: A total of 5,972 men and women, aged 45-84 years and without a history of cardiovascular disease at baseline in the Multi-Ethnic Study of Atherosclerosis (MESA) were followed from 2000 to 2014 for incident AF with baseline coffee consumption assessed in 2000-2002 via a Food Frequency Questionnaire and divided into quartiles of 0 cups/day, >0 to <0.5 cups/day, ≥0.5 to 1.5 cups/day, and ≥1.5 cups/day.

RESULTS: Out of the 828 incident cases of AF, intermittent coffee consumption (>0 to 0.5 cups of daily coffee) was associated with a greater risk of incident AF (HR 1.22, 95% CI 1.01-1.48) relative to 0 cups/day in multivariable Cox proportional hazards models after adjustment for numerous AF risk factors. This relation was particularly pronounced in men (adjusted HR=1.36, 95% CI 1.04-1.77). Higher coffee consumption was not associated with AF risk (HR 1.03, 95%CI 0.93-1.14 for ≥0.5 to 1.5 cups/day and 1.05, 95%CI 0.97-1.13 for ≥1.5 cups/day).

CONCLUSIONS: While there appears to be no dose-response association between habitual coffee intake and AF risk, we found evidence that intermittent, but not habitual, coffee consumption is associated with a modestly increased risk of incident AF that deserves further study.

Keywords: Atrial Fibrillation; Caffeine; Cardiovascular Disease; Coffee; Epidemiology

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