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Yang G, Song W, Postoak JL, et al. Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function. Autophagy. 2020;17(5):1193-1204doi: 10.1080/15548627.2020.1752979.
Yang, G., Song, W., Postoak, J. L., Chen, J., Martinez, J., Zhang, J., Wu, L., & Van Kaer, L. (2021). Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function. Autophagy, 17(5), 1193-1204. https://doi.org/10.1080/15548627.2020.1752979
Yang, Guan, et al. "Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function." Autophagy vol. 17,5 (2021): 1193-1204. doi: https://doi.org/10.1080/15548627.2020.1752979
Yang G, Song W, Postoak JL, Chen J, Martinez J, Zhang J, Wu L, Van Kaer L. Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function. Autophagy. 2021 May;17(5):1193-1204. doi: 10.1080/15548627.2020.1752979. Epub 2020 Apr 16. PMID: 32268825; PMCID: PMC8143264.
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Autophagy. 2021 May;17(5):1193-1204. doi: 10.1080/15548627.2020.1752979. Epub 2020 Apr 16.

Autophagy-related protein PIK3C3/VPS34 controls T cell metabolism and function.

Autophagy

Guan Yang, Wenqiang Song, J Luke Postoak, Jin Chen, Jennifer Martinez, Jianhua Zhang, Lan Wu, Luc Van Kaer

Affiliations

  1. Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
  2. Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
  3. Veterans Affairs Medical Center, Tennessee Valley Healthcare System, Nashville, TN, USA.
  4. Immunity, Inflammation, and Disease Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, Durham, NC, USA.
  5. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
  6. Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA.

PMID: 32268825 PMCID: PMC8143264 DOI: 10.1080/15548627.2020.1752979

Abstract

The PIK3C3/VPS34 subunit of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex is a key early player in macroautophagy/autophagy. In this study, we assessed the contribution of PIK3C3 to T cell metabolism and function. We found that

Keywords: Autophagy; PIK3C3/VPS34; T cell differentiation; T cell metabolism; experimental autoimmune encephalomyelitis

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