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Dragano NRV, Fernø J, Diéguez C, et al. Recent Updates on Obesity Treatments: Available Drugs and Future Directions. Neuroscience. 2020;437:215-239doi: 10.1016/j.neuroscience.2020.04.034.
Dragano, N. R. V., Fernø, J., Diéguez, C., López, M., & Milbank, E. (2020). Recent Updates on Obesity Treatments: Available Drugs and Future Directions. Neuroscience, 437215-239. https://doi.org/10.1016/j.neuroscience.2020.04.034
Dragano, Nathalia R V, et al. "Recent Updates on Obesity Treatments: Available Drugs and Future Directions." Neuroscience vol. 437 (2020): 215-239. doi: https://doi.org/10.1016/j.neuroscience.2020.04.034
Dragano NRV, Fernø J, Diéguez C, López M, Milbank E. Recent Updates on Obesity Treatments: Available Drugs and Future Directions. Neuroscience. 2020 Jun 15;437:215-239. doi: 10.1016/j.neuroscience.2020.04.034. Epub 2020 Apr 29. PMID: 32360593.
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Neuroscience. 2020 Jun 15;437:215-239. doi: 10.1016/j.neuroscience.2020.04.034. Epub 2020 Apr 29.

Recent Updates on Obesity Treatments: Available Drugs and Future Directions.

Neuroscience

Nathalia R V Dragano, Johan Fernø, Carlos Diéguez, Miguel López, Edward Milbank

Affiliations

  1. NeurObesity Group, Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 15706, Spain. Electronic address: [email protected].
  2. Hormone Laboratory, Haukeland University Hospital, N-5021 Bergen, Norway.
  3. NeurObesity Group, Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 15706, Spain.
  4. NeurObesity Group, Department of Physiology, CiMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 15706, Spain. Electronic address: [email protected].

PMID: 32360593 DOI: 10.1016/j.neuroscience.2020.04.034

Abstract

In the last thirty years, obesity has reached epidemic proportions and is now regarded as a major health issue in contemporary society trending to serious economic and social burdens. The latest projections of the World Health Organization are alarming. By 2030, nearly 60% of the worldwide population could be either obese or overweight, highlighting the needs to find innovative treatments. Currently, bariatric surgery is the most effective way to efficiently lower body mass. Although great improvements in terms of recovery and patient care were made in these surgical procedures, bariatric surgery remains an option for extreme forms of obesity and seems unable to tackle obesity pandemic expansion. Throughout the last century, numerous pharmacological strategies targeting either peripheral or central components of the energy balance regulatory system were designed to reduce body mass, some of them reaching sufficient levels of efficiency and safety. Nevertheless, obesity drug therapy remains quite limited on its effectiveness to actually overcome the obesogenic environment. Thus, innovative unimolecular polypharmacology strategies, able to simultaneously target multiple actors involved in the obesity initiation and expansion, were developed during the last ten years opening a new promising avenue in the pharmacological management of obesity. In this review, we first describe the clinical features of obesity-associated conditions and then focus on the outcomes of currently approved drug therapies for obesity as well as new ones expecting to reach the clinic in the near future.

Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

Keywords: associated-pathologies; obesity; pharmacotherapy; polypharmacology

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

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