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Lim AC, Green R, Grodin EN, et al. Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration. Alcohol Clin Exp Res. 2020;44(6):1224-1233doi: 10.1111/acer.14342.
Lim, A. C., Green, R., Grodin, E. N., Venegas, A., Meredith, L. R., Donato, S., Burnette, E., & Ray, L. A. (2020). Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration. Alcoholism, clinical and experimental research, 44(6), 1224-1233. https://doi.org/10.1111/acer.14342
Lim, Aaron C, et al. "Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration." Alcoholism, clinical and experimental research vol. 44,6 (2020): 1224-1233. doi: https://doi.org/10.1111/acer.14342
Lim AC, Green R, Grodin EN, Venegas A, Meredith LR, Donato S, Burnette E, Ray LA. Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration. Alcohol Clin Exp Res. 2020 Jun;44(6):1224-1233. doi: 10.1111/acer.14342. Epub 2020 May 14. PMID: 32406553; PMCID: PMC7336863.
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Alcohol Clin Exp Res. 2020 Jun;44(6):1224-1233. doi: 10.1111/acer.14342. Epub 2020 May 14.

Alcohol Cue-Induced Ventral Striatum Activity Predicts Subsequent Alcohol Self-Administration.

Alcoholism, clinical and experimental research

Aaron C Lim, ReJoyce Green, Erica N Grodin, Alexandra Venegas, Lindsay R Meredith, Suzanna Donato, Elizabeth Burnette, Lara A Ray

Affiliations

  1. From the, Department of Psychology, (ACL, RG, ENG, AV, LRM, SD, EB, LAR), University of California, Los Angeles, Los Angeles, California, United States.
  2. Department of Psychiatry and Biobehavioral Sciences, (LAR), University of California, Los Angeles, Los Angeles, California, USA.

PMID: 32406553 PMCID: PMC7336863 DOI: 10.1111/acer.14342

Abstract

BACKGROUND: Human laboratory paradigms are a pillar in medication development for alcohol use disorders (AUD). Neuroimaging paradigms, in which individuals are exposed to cues that elicit neural correlates of alcohol craving (e.g., mesocorticolimbic activation), are increasingly utilized to test the effects of AUD medications. Elucidation of the translational effects of these neuroimaging paradigms on human laboratory paradigms, such as self-administration, is warranted. The current study is a secondary analysis examining whether alcohol cue-induced activation in the ventral striatum is predictive of subsequent alcohol self-administration in the laboratory.

METHODS: Non-treatment-seeking heavy drinkers of East Asian descent (n = 41) completed a randomized, placebo-controlled, double-blind, crossover experiment on the effects of naltrexone on neuroimaging and human laboratory paradigms. Participants completed 5 days of study medication (or placebo); on day 4, they completed a neuroimaging alcohol taste cue-reactivity task. On the following day (day 5), participants completed a 60-minute alcohol self-administration paradigm.

RESULTS: Multilevel Cox regressions indicated a significant effect of taste cue-elicited ventral striatum activation on latency to first drink, Wald χ

CONCLUSIONS: Neuroimaging alcohol taste cue paradigms may be predictive of laboratory paradigms such as self-administration. Elucidation of the relationships among different paradigms will inform how these paradigms may be used synergistically in experimental medicine and medication development.

© 2020 by the Research Society on Alcoholism.

Keywords: Alcohol Self-administration; Cue-Induced Craving; Human Laboratory; Neuroimaging; Ventral Striatum

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