Display options
Cite
Soattin L, Lubberding AF, Bentzen BH, et al. Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation. Front Physiol. 2020;11:493doi: 10.3389/fphys.2020.00493.
Soattin, L., Lubberding, A. F., Bentzen, B. H., Christ, T., & Jespersen, T. (2020). Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation. Frontiers in physiology, 11493. https://doi.org/10.3389/fphys.2020.00493
Soattin, Luca, et al. "Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation." Frontiers in physiology vol. 11 (2020): 493. doi: https://doi.org/10.3389/fphys.2020.00493
Soattin L, Lubberding AF, Bentzen BH, Christ T, Jespersen T. Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation. Front Physiol. 2020 Jun 12;11:493. doi: 10.3389/fphys.2020.00493. eCollection 2020. PMID: 32595514; PMCID: PMC7304385.
Copy Download .nbib Format: NLM
Share it on

Front Physiol. 2020 Jun 12;11:493. doi: 10.3389/fphys.2020.00493. eCollection 2020.

Inhibition of Adenosine Pathway Alters Atrial Electrophysiology and Prevents Atrial Fibrillation.

Frontiers in physiology

Luca Soattin, Anniek Frederike Lubberding, Bo Hjorth Bentzen, Torsten Christ, Thomas Jespersen

Affiliations

  1. Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  2. Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  3. DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, Hamburg, Germany.

PMID: 32595514 PMCID: PMC7304385 DOI: 10.3389/fphys.2020.00493

Abstract

BACKGROUND: Adenosine leads to atrial action potential (AP) shortening through activation of adenosine 1 receptors (A

OBJECTIVE: The aim of this study was to address whether the pharmacological blockade of endogenous production of adenosine and of its signaling prevents atrial fibrillation (AF).

METHODS: The role of A

RESULTS: As expected, CCPA shortened AP duration at 90% of repolarization (APD

CONCLUSION: A

Copyright © 2020 Soattin, Lubberding, Bentzen, Christ and Jespersen.

Keywords: A1-R; CD73; adenosine; arrhythmias; hypoxia; translational models

References

  1. J Cardiovasc Pharmacol. 2015 Aug;66(2):165-76 - PubMed
  2. Am J Physiol. 1990 Jun;258(6 Pt 2):H1815-22 - PubMed
  3. J Physiol. 1999 Dec 15;521 Pt 3:587-99 - PubMed
  4. Can J Physiol Pharmacol. 2015 Aug;93(8):667-75 - PubMed
  5. Circulation. 1997 Mar 18;95(6):1363-5 - PubMed
  6. Gen Physiol Biophys. 2015 Oct;34(4):383-92 - PubMed
  7. N Engl J Med. 2011 Aug 11;365(6):537-47 - PubMed
  8. N Engl J Med. 2011 Feb 17;364(7):656-65 - PubMed
  9. J Physiol. 2003 Jun 15;549(Pt 3):823-33 - PubMed
  10. Ann N Y Acad Sci. 2001 Jun;939:74-84 - PubMed
  11. Cardiovasc Res. 1996 Nov;32(5):797-813 - PubMed
  12. J Am Coll Cardiol. 2004 Jul 7;44(1):109-16 - PubMed
  13. Circulation. 2014 Jul 22;130(4):315-24 - PubMed
  14. J Neurochem. 2001 Nov;79(3):463-84 - PubMed
  15. FASEB J. 1995 Mar;9(5):359-65 - PubMed
  16. Basic Res Cardiol. 2016 Jan;111(1):5 - PubMed
  17. Am J Cardiol. 1984 May 1;53(9):1405-6 - PubMed
  18. Cardiovasc Res. 2006 Nov 1;72(2):292-302 - PubMed
  19. J Pharmacol Exp Ther. 1987 Sep;242(3):791-5 - PubMed
  20. J Arrhythm. 2017 Aug;33(4):247-255 - PubMed
  21. Pharmacol Rev. 2001 Dec;53(4):527-52 - PubMed
  22. Am J Physiol. 1990 Apr;258(4 Pt 2):H1070-8 - PubMed
  23. Circ J. 2017 Nov 24;81(12):1749-1757 - PubMed
  24. Int J Cardiol Heart Vasc. 2019 Jan 08;22:84-91 - PubMed
  25. Am J Cardiol. 2004 Dec 15;94(12):1486-90 - PubMed
  26. Trends Mol Med. 2013 Jun;19(6):345-54 - PubMed
  27. J Am Soc Nephrol. 2017 Mar;28(3):888-902 - PubMed
  28. J Med Chem. 2014 May 8;57(9):3623-50 - PubMed
  29. Eur Heart J. 2011 Mar;32(6):721-9 - PubMed
  30. Circ Arrhythm Electrophysiol. 2013 Jun;6(3):e34-7 - PubMed
  31. J Biol Chem. 1998 Jul 10;273(28):17610-7 - PubMed
  32. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1547-52 - PubMed
  33. Circulation. 2016 Aug 9;134(6):486-98 - PubMed
  34. Am J Physiol. 1990 Dec;259(6 Pt 2):H1730-5 - PubMed
  35. Nature. 1985 Oct 10-16;317(6037):536-8 - PubMed
  36. J Am Coll Cardiol. 2004 Jan 21;43(2):241-7 - PubMed
  37. Eur J Emerg Med. 2001 Jun;8(2):141-5 - PubMed
  38. J Cardiovasc Pharmacol. 2011 Jun;57(6):672-81 - PubMed
  39. Circulation. 2001 Jul 10;104(2):174-80 - PubMed
  40. Europace. 2010 Feb;12(2):160-72 - PubMed
  41. Biochim Biophys Acta. 2011 May;1808(5):1290-308 - PubMed
  42. Cardiovasc Res. 1994 Sep;28(9):1385-9 - PubMed
  43. Am J Respir Crit Care Med. 1999 Mar;159(3):1014-8 - PubMed
  44. Am J Physiol. 1983 May;244(5):H734-7 - PubMed
  45. Circulation. 2005 Dec 13;112(24):3697-706 - PubMed
  46. J Exp Med. 2004 Dec 6;200(11):1395-405 - PubMed
  47. J Cardiovasc Electrophysiol. 2014 Dec;25(12):1284-92 - PubMed
  48. Prog Cardiovasc Dis. 2009 Mar-Apr;51(5):411-5 - PubMed
  49. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jun;337(6):687-9 - PubMed
  50. J Physiol. 1929 Nov 25;68(3):213-37 - PubMed
  51. PLoS One. 2009 Aug 26;4(8):e6784 - PubMed
  52. Nat Rev Drug Discov. 2006 Mar;5(3):247-64 - PubMed
  53. Hypertension. 2011 Jun;57(6):1129-35 - PubMed
  54. Ann Intern Med. 1997 Sep 15;127(6):417-22 - PubMed
  55. Pacing Clin Electrophysiol. 1998 May;21(5):1029-34 - PubMed
  56. Circulation. 2004 Aug 24;110(8):897-903 - PubMed
  57. J Clin Invest. 1974 May;53(5):1447-57 - PubMed
  58. Am Heart J. 1977 Jun;93(6):735-40 - PubMed
  59. Am J Physiol. 1989 Apr;256(4 Pt 1):C799-806 - PubMed
  60. Cardiovasc Res. 1994 Jun;28(6):760-1 - PubMed
  61. J Interv Card Electrophysiol. 1997 Feb;1(1):33-7 - PubMed
  62. Toxicol Sci. 2011 May;121(1):11-30 - PubMed
  63. J Cardiovasc Pharmacol. 2013 Aug;62(2):192-8 - PubMed
  64. Purinergic Signal. 2008 Mar;4(1):21-37 - PubMed
  65. Circulation. 2007 Mar 27;115(12):1581-90 - PubMed
  66. Europace. 2016 Mar;18(3):340-6 - PubMed
  67. Naunyn Schmiedebergs Arch Pharmacol. 2008 Mar;377(1):65-76 - PubMed
  68. Clin Cardiol. 1989 Feb;12(2):76-82 - PubMed
  69. Circ Res. 2004 Oct 15;95(8):814-21 - PubMed
  70. Cardiovasc Pathol. 2010 Mar-Apr;19(2):102-11 - PubMed
  71. Circ Res. 1991 Sep;69(3):571-81 - PubMed
  72. Biomed Biochim Acta. 1983;42(1):83-94 - PubMed
  73. Circulation. 2006 Dec 5;114(23):2434-42 - PubMed
  74. Purinergic Signal. 2006 Jun;2(2):351-60 - PubMed
  75. J Physiol. 2016 May 1;594(9):2387-98 - PubMed
  76. Arrhythm Electrophysiol Rev. 2015 May;4(1):14-8 - PubMed
  77. Am J Physiol Heart Circ Physiol. 2002 Jun;282(6):H2183-9 - PubMed
  78. Circulation. 2003 Apr 15;107(14):1930-6 - PubMed
  79. Biochim Biophys Acta. 2011 May;1808(5):1413-28 - PubMed
  80. Int J Mol Sci. 2014 Jan 28;15(2):2024-52 - PubMed
  81. Ann Intern Med. 1990 Jul 15;113(2):104-10 - PubMed
  82. Prog Cardiovasc Dis. 1989 Jul-Aug;32(1):73-97 - PubMed
  83. Heart. 1997 Jul;78(1):88-90 - PubMed
  84. Trends Mol Med. 2013 Jun;19(6):355-67 - PubMed

Publication Types