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Lopera Maya EA, van der Graaf A, Lanting P, et al. Lack of Association Between Genetic Variants at . Front Genet. 2020;11:613doi: 10.3389/fgene.2020.00613.
Lopera Maya, E. A., van der Graaf, A., Lanting, P., van der Geest, M., Fu, J., Swertz, M., Franke, L., Wijmenga, C., Deelen, P., Zhernakova, A., Sanna, S. (2020). Lack of Association Between Genetic Variants at . Frontiers in genetics, 11613. https://doi.org/10.3389/fgene.2020.00613
Lopera Maya, Esteban A, et al. "Lack of Association Between Genetic Variants at ." Frontiers in genetics vol. 11 (2020): 613. doi: https://doi.org/10.3389/fgene.2020.00613
Lopera Maya EA, van der Graaf A, Lanting P, van der Geest M, Fu J, Swertz M, Franke L, Wijmenga C, Deelen P, Zhernakova A, Sanna S. Lack of Association Between Genetic Variants at . Front Genet. 2020 Jun 08;11:613. doi: 10.3389/fgene.2020.00613. eCollection 2020. PMID: 32582302; PMCID: PMC7295011.
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Front Genet. 2020 Jun 08;11:613. doi: 10.3389/fgene.2020.00613. eCollection 2020.

Lack of Association Between Genetic Variants at .

Frontiers in genetics

Esteban A Lopera Maya, Adriaan van der Graaf, Pauline Lanting, Marije van der Geest, Jingyuan Fu, Morris Swertz, Lude Franke, Cisca Wijmenga, Patrick Deelen, Alexandra Zhernakova, Serena Sanna,

Affiliations

  1. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
  2. Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
  3. Department of Genetics, University Medical Centre Utrecht, Utrecht, Netherlands.
  4. Institute for Genetics and Biomedical Research (IRGB), Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy.

PMID: 32582302 PMCID: PMC7295011 DOI: 10.3389/fgene.2020.00613

Abstract

Coronavirus disease 2019 (COVID-19) shows a wide variation in expression and severity of symptoms, from very mild or no symptoms, to flu-like symptoms, and in more severe cases, to pneumonia, acute respiratory distress syndrome, and even death. Large differences in outcome have also been observed between males and females. The causes for this variability are likely to be multifactorial, and to include genetics. The SARS-CoV-2 virus responsible for the infection depends on two human genes: the human receptor angiotensin converting enzyme 2 (

Copyright © 2020 Lopera Maya, van der Graaf, Lanting, van der Geest, Fu, Swertz, Franke, Wijmenga, Deelen, Zhernakova, Sanna and Lifelines Cohort Study.

Keywords: ACE2; ARBs (angiotensin II receptor blockers); COVID-19; NSAIDs (non-steroidal anti-inflammatory drugs); PheWAS; SARS-CoV-2; TMPRSS2

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