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Clin Pharmacol Ther. 2021 Jan;109(1):29-36. doi: 10.1002/cpt.2049. Epub 2020 Oct 17.

Perspectives on Model-Informed Precision Dosing in the Digital Health Era: Challenges, Opportunities, and Recommendations.

Clinical pharmacology and therapeutics

Franziska Kluwe, Robin Michelet, Anna Mueller-Schoell, Corinna Maier, Lena Klopp-Schulze, Madelé van Dyk, Gerd Mikus, Wilhelm Huisinga, Charlotte Kloft

Affiliations

  1. Department of Clinical Pharmacy and Biochemistry, Institute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
  2. Graduate Research Training Program PharMetrX, Freie Universität Berlin and Universitaet Potsdam, Berlin, Germany.
  3. Institute of Mathematics, Universität Potsdam, Potsdam, Germany.
  4. Flinders Centre for Innovation in Cancer, College of Medicine & Public Health, Flinders University, Adelaide, Australia.
  5. Department of Clinical Pharmacology and Pharmacoepidemiology, University Hospital Heidelberg, Heidelberg, Germany.

PMID: 33068303 DOI: 10.1002/cpt.2049

[No abstract available.]

References

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  4. Klopp-Schulze, L. et al. Integrated data analysis of six clinical studies points toward model-informed precision dosing of tamoxifen. Front. Pharmacol. 11, 1-19 (2020). - PubMed
  5. Kumar, A.A. et al. An evaluation of the user-friendliness of Bayesian forecasting programs in a clinical setting. Br. J. Clin. Pharmacol. 85, 2436-2441 (2019). - PubMed
  6. Roggeveen, L.F. et al. Right dose, right now: development of autokinetics for real time model informed precision antibiotic dosing decision support at the bedside of critically ill patients. Front. Pharmacol. 11, 1-16 (2020). - PubMed
  7. Hennig, S., Fischer, J. & Kloft, C. What, “impact” do NLME Publications have outside our community? CPT Pharmacometrics Syst. Pharmacol. 9, 191-194 (2020). - PubMed
  8. Menz, B.D. et al. Barriers and opportunities for the clinical implementation of therapeutic drug monitoring in oncology. Br. J. Clin. Pharmacol. https://doi.org/10.1111/bcp.14372. - PubMed
  9. Ates, H.C. et al. On-site therapeutic drug monitoring. Trends Biotechnol. https://doi.org/10.1016/j.tibtech.2020.03.001. - PubMed
  10. Vinks, A.A., Peck, R.W., Neely, M. & Mould, D.R. Development and implementation of electronic health record-integrated model-informed clinical decision support tools for the precision dosing of drugs. Clin. Pharmacol. Ther. 107, 129-135 (2020). - PubMed
  11. Traynor, K. FDA examines precision dosing. Am. J. Health Syst. Pharm. 76, 1999-2000 (2019). - PubMed

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