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Han WM, Jiamsakul A, Jantarapakde J, et al. Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV. HIV Med. 2020;22(4):294-306doi: 10.1111/hiv.13017.
Han, W. M., Jiamsakul, A., Jantarapakde, J., Yunihastuti, E., Choi, J. Y., Ditangco, R., Chaiwarith, R., Sun, L. P., Khusuwan, S., Merati, T. P., Do, C. D., Azwa, I., Lee, M. P., Van Nguyen, K., Chan, Y. J., Kiertiburanakul, S., Ng, O. T., Tanuma, J., Pujari, S., Zhang, F., Gani, Y. M., Sangle, S., Ross, J., Kumarasamy, N. (2021). Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV. HIV medicine, 22(4), 294-306. https://doi.org/10.1111/hiv.13017
Han, W M, et al. "Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV." HIV medicine vol. 22,4 (2021): 294-306. doi: https://doi.org/10.1111/hiv.13017
Han WM, Jiamsakul A, Jantarapakde J, Yunihastuti E, Choi JY, Ditangco R, Chaiwarith R, Sun LP, Khusuwan S, Merati TP, Do CD, Azwa I, Lee MP, Van Nguyen K, Chan YJ, Kiertiburanakul S, Ng OT, Tanuma J, Pujari S, Zhang F, Gani YM, Sangle S, Ross J, Kumarasamy N. Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV. HIV Med. 2021 Apr;22(4):294-306. doi: 10.1111/hiv.13017. Epub 2020 Nov 17. PMID: 33200864; PMCID: PMC8428815.
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HIV Med. 2021 Apr;22(4):294-306. doi: 10.1111/hiv.13017. Epub 2020 Nov 17.

Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV.

HIV medicine

W M Han, A Jiamsakul, J Jantarapakde, E Yunihastuti, J Y Choi, R Ditangco, R Chaiwarith, L P Sun, S Khusuwan, T P Merati, C D Do, I Azwa, M-P Lee, K Van Nguyen, Y-J Chan, S Kiertiburanakul, O T Ng, J Tanuma, S Pujari, F Zhang, Y M Gani, S Sangle, J Ross, N Kumarasamy,

Affiliations

  1. The Kirby Institute, UNSW, Sydney, NSW, Australia.
  2. HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  3. Faculty of Medicine, Universitas Indonesia - Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia.
  4. Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
  5. Research Institute for Tropical Medicine, Muntinlupa City, Philippines.
  6. Research Institute for Health Sciences, Chiang Mai, Thailand.
  7. National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia.
  8. Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand.
  9. Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia.
  10. Bach Mai Hospital, Hanoi, Vietnam.
  11. University Malaya Medical Centre, Kuala Lumpur, Malaysia.
  12. Queen Elizabeth Hospital, Hong Kong SAR, India.
  13. National Hospital for Tropical Diseases, Hanoi, Vietnam.
  14. Taipei Veterans General Hospital, Taipei, Taiwan.
  15. Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  16. Tan Tock Seng Hospital, Singapore, Singapore.
  17. National Center for Global Health and Medicine, Tokyo, Japan.
  18. Institute of Infectious Diseases, Pune, India.
  19. Beijing Ditan Hospital, Capital Medical University, Beijing, China.
  20. Hospital Sungai Buloh, Sungai Buloh, Malaysia.
  21. BJ Government Medical College and Sassoon General Hospital, Pune, India.
  22. TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand.
  23. Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India.

PMID: 33200864 PMCID: PMC8428815 DOI: 10.1111/hiv.13017

Abstract

OBJECTIVES: We conducted a longitudinal cohort analysis to evaluate the association of pre-treatment body mass index (BMI) with CD4 recovery, virological failure (VF) and cardiovascular risk disease (CVD) markers among people living with HIV (PLHIV).

METHODS: Participants who were enrolled between January 2003 and March 2019 in a regional Asia HIV cohort with weight and height measurements prior to antiretroviral therapy (ART) initiation were included. Factors associated with mean CD4 increase were analysed using repeated-measures linear regression. Time to first VF after 6 months on ART and time to first development of CVD risk markers were analysed using Cox regression models. Sensitivity analyses were done adjusting for Asian BMI thresholds.

RESULTS: Of 4993 PLHIV (66% male), 62% had pre-treatment BMI in the normal range (18.5-25.0 kg/m

CONCLUSIONS: High pre-treatment BMI was associated with better immune reconstitution and CVD risk factor development in an Asian PLHIV cohort.

© 2020 British HIV Association.

Keywords: HIV; body mass index; cardiovascular risks; immune recovery; virological response

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