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Chen BT, Chen Z, Patel SK, et al. Effect of chemotherapy on default mode network connectivity in older women with breast cancer. Brain Imaging Behav. 2021;doi: 10.1007/s11682-021-00475-y.
Chen, B. T., Chen, Z., Patel, S. K., Rockne, R. C., Wong, C. W., Root, J. C., Saykin, A. J., Ahles, T. A., Holodny, A. I., Sun, C. L., Sedrak, M. S., Kim, H., Celis, A., Katheria, V., & Dale, W. (2021). Effect of chemotherapy on default mode network connectivity in older women with breast cancer. Brain imaging and behavior, . https://doi.org/10.1007/s11682-021-00475-y
Chen, Bihong T, et al. "Effect of chemotherapy on default mode network connectivity in older women with breast cancer." Brain imaging and behavior vol. (2021). doi: https://doi.org/10.1007/s11682-021-00475-y
Chen BT, Chen Z, Patel SK, Rockne RC, Wong CW, Root JC, Saykin AJ, Ahles TA, Holodny AI, Sun CL, Sedrak MS, Kim H, Celis A, Katheria V, Dale W. Effect of chemotherapy on default mode network connectivity in older women with breast cancer. Brain Imaging Behav. 2021 May 21; doi: 10.1007/s11682-021-00475-y. Epub 2021 May 21. PMID: 34019223; PMCID: PMC8606014.
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Brain Imaging Behav. 2021 May 21; doi: 10.1007/s11682-021-00475-y. Epub 2021 May 21.

Effect of chemotherapy on default mode network connectivity in older women with breast cancer.

Brain imaging and behavior

Bihong T Chen, Zikuan Chen, Sunita K Patel, Russell C Rockne, Chi Wah Wong, James C Root, Andrew J Saykin, Tim A Ahles, Andrei I Holodny, Can-Lan Sun, Mina S Sedrak, Heeyoung Kim, Ashley Celis, Vani Katheria, William Dale

Affiliations

  1. Department of Diagnostic Radiology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91010, USA. [email protected].
  2. Center for Cancer and Aging, City of Hope National Medical Center, Duarte, CA, 91010, USA. [email protected].
  3. Department of Diagnostic Radiology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA, 91010, USA.
  4. Department of Population Science, City of Hope National Medical Center, Duarte, CA, 91010, USA.
  5. Division of Mathematical Oncology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
  6. Applied AI and Data Science, City of Hope National Medical Center, Duarte, CA, 91010, USA.
  7. Neurocognitive Research Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  8. Center for Neuroimaging, Indiana University School of Medicine, Indianapolis, IN, USA.
  9. Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
  10. Center for Cancer and Aging, City of Hope National Medical Center, Duarte, CA, 91010, USA.
  11. Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA, 91010, USA.
  12. Department of Supportive Care Medicine, City of Hope National Medical Center, Duarte, CA, 91010, USA.

PMID: 34019223 PMCID: PMC8606014 DOI: 10.1007/s11682-021-00475-y

Abstract

Chemotherapy may impair cognition and contribute to accelerated aging. The purpose of this study was to assess the effects of chemotherapy on the connectivity of the default mode network (DMN) in older women with breast cancer. This prospective longitudinal study enrolled women aged ≥ 60 years with stage I-III breast cancer (CTx group) and matched healthy controls (HC group). Study assessments, consisting of resting-state functional MRI (rs-fMRI) and the Picture Sequence Memory (psm) test for episodic memory from the NIH Toolbox for Cognition, were obtained at baseline and within one month after the completion of chemotherapy for the CTx group and at matched intervals for the HC group. Two-sample t-test and FDR multiple comparison were used for statistical inference. Our analysis of the CTx group (N = 19; 60-82 years of age, mean = 66.6, SD = 5.24) compared to the HC group (N = 14; 60-78 years of age, mean = 68.1, SD = 5.69) revealed weaker DMN subnetwork connectivity in the anterior brain but stronger connectivity in the posterior brain at baseline. After chemotherapy, this pattern was reversed, with stronger anterior connectivity and weaker posterior connectivity. In addition, the meta-level functional network connectivity (FNC) among the DMN subnetworks after chemotherapy was consistently weaker than the baseline FNC as seen in the couplings between anterior cingulate cortex (ACC) and retrosplenial (rSplenia) region, with ΔFNC('ACC','rSplenia')=-0.14, t value=-2.44, 95 %CI=[-0.27,-0.10], p

Keywords: Breast cancer; Cancer‐related cognitive impairment (CRCI); Chemotherapy; Default mode network; Episodic memory

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