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Rao VKS, Eipper BA, Mains RE. Multiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia. J Cell Physiol. 2021;236(11):7745-7758doi: 10.1002/jcp.30457.
Rao, V. K. S., Eipper, B. A., & Mains, R. E. (2021). Multiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia. Journal of cellular physiology, 236(11), 7745-7758. https://doi.org/10.1002/jcp.30457
Rao, Vishwanatha K S, et al. "Multiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia." Journal of cellular physiology vol. 236,11 (2021): 7745-7758. doi: https://doi.org/10.1002/jcp.30457
Rao VKS, Eipper BA, Mains RE. Multiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia. J Cell Physiol. 2021 Nov;236(11):7745-7758. doi: 10.1002/jcp.30457. Epub 2021 Jun 01. PMID: 34061983.
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J Cell Physiol. 2021 Nov;236(11):7745-7758. doi: 10.1002/jcp.30457. Epub 2021 Jun 01.

Multiple roles for peptidylglycine α-amidating monooxygenase in the response to hypoxia.

Journal of cellular physiology

Vishwanatha K S Rao, Betty A Eipper, Richard E Mains

Affiliations

  1. Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA.
  2. Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, Connecticut, USA.

PMID: 34061983 DOI: 10.1002/jcp.30457

Abstract

The biosynthesis of many of the peptides involved in homeostatic control requires peptidylglycine α-amidating monooxygenase (PAM), an ancient, highly conserved copper- and ascorbate-dependent enzyme. Using the production of amidated chromogranin A to monitor PAM function in tumor cells, physiologically relevant levels of hypoxia were shown to inhibit this monooxygenase. The ability of primary pituitary cells exposed to hypoxic conditions for 4 h to produce amidated chromogranin A was similarly inhibited. The affinity of the purified monooxygenase for oxygen (K

© 2021 Wiley Periodicals LLC.

Keywords: HIF1a; RNAseq; atrium; basal secretion; chromogranin A; corticotrope; pituitary

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