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Han L, Jia Y, Zhao Y, et al. Metabolic activation of zolmitriptan mediated by CYP2D6. Xenobiotica. 2021;51(11):1292-1302doi: 10.1080/00498254.2021.1938290.
Han, L., Jia, Y., Zhao, Y., Sun, C., Zhao, M., Peng, Y., & Zheng, J. (2021). Metabolic activation of zolmitriptan mediated by CYP2D6. Xenobiotica; the fate of foreign compounds in biological systems, 51(11), 1292-1302. https://doi.org/10.1080/00498254.2021.1938290
Han, Lingling, et al. "Metabolic activation of zolmitriptan mediated by CYP2D6." Xenobiotica; the fate of foreign compounds in biological systems vol. 51,11 (2021): 1292-1302. doi: https://doi.org/10.1080/00498254.2021.1938290
Han L, Jia Y, Zhao Y, Sun C, Zhao M, Peng Y, Zheng J. Metabolic activation of zolmitriptan mediated by CYP2D6. Xenobiotica. 2021 Nov;51(11):1292-1302. doi: 10.1080/00498254.2021.1938290. Epub 2021 Nov 03. PMID: 34096834.
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Xenobiotica. 2021 Nov;51(11):1292-1302. doi: 10.1080/00498254.2021.1938290. Epub 2021 Nov 03.

Metabolic activation of zolmitriptan mediated by CYP2D6.

Xenobiotica; the fate of foreign compounds in biological systems

Lingling Han, Yudi Jia, Yanjia Zhao, Chen Sun, Min Zhao, Ying Peng, Jiang Zheng

Affiliations

  1. Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, P. R. China.
  2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang, P. R. China.
  3. Key Laboratory of Environmental Pollution, Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, P. R. China.

PMID: 34096834 DOI: 10.1080/00498254.2021.1938290

Abstract

Zolmitriptan (ZOL), a member of triptans, has been used for the treatment of migraine with definite therapeutic effects. However, several cases of liver injury associated with ZOL have been reported and the underlying mechanisms remain unclear.The present study aimed to investigate the metabolic activation of ZOL

Keywords: CYP2D6; HPLC-MS/MS; Zolmitriptan; metabolic activation

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