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Wang RX, Henen MA, Lee JS, et al. Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut Microbes. 2021;13(1):1938380doi: 10.1080/19490976.2021.1938380.
Wang, R. X., Henen, M. A., Lee, J. S., Vögeli, B., & Colgan, S. P. (2021). Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut microbes, 13(1), 1938380. https://doi.org/10.1080/19490976.2021.1938380
Wang, Ruth X, et al. "Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor." Gut microbes vol. 13,1 (2021): 1938380. doi: https://doi.org/10.1080/19490976.2021.1938380
Wang RX, Henen MA, Lee JS, Vögeli B, Colgan SP. Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor. Gut Microbes. 2021 Jan-Dec;13(1):1938380. doi: 10.1080/19490976.2021.1938380. PMID: 34190032; PMCID: PMC8253137.
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Gut Microbes. 2021 Jan-Dec;13(1):1938380. doi: 10.1080/19490976.2021.1938380.

Microbiota-derived butyrate is an endogenous HIF prolyl hydroxylase inhibitor.

Gut microbes

Ruth X Wang, Morkos A Henen, J Scott Lee, Beat Vögeli, Sean P Colgan

Affiliations

  1. Department of Medicine, Mucosal Inflammation Program, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  2. School of Medicine, Medical Scientist Training Program, University of Colorado, Aurora, CO, USA.
  3. Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  4. Department of Pharmaceutical Organic Chemistry, Mansoura University, Mansoura, Egypt.

PMID: 34190032 PMCID: PMC8253137 DOI: 10.1080/19490976.2021.1938380

Abstract

The gut microbiota is essential for human health. Microbial supply of short-chain fatty acids (SCFAs), particularly butyrate, is a well-established contributor to gut homeostasis and disease resistance. Reaching millimolar luminal concentrations, butyrate is sequestered and utilized in the colon as the favored energy source for intestinal epithelia. Given the steep oxygen gradient across the anoxic lumen and the highly oxygenated lamina propria, the colon provides a particularly interesting environment to study oxygen sensing. Previous studies have shown that the transcription factor hypoxia-inducible factor (HIF) is stabilized in healthy colonic epithelia. Here we show that butyrate directly inhibits HIF prolyl hydroxylases (PHDs) to stabilize HIF. We find that butyrate stabilizes HIF

Keywords: Microbiota; butyrate; hypoxia-inducible factor; inhibition; prolyl-hydroxylase; short-chain fatty acids

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